دورية أكاديمية
Bovine colostrum supplementation improves bone metabolism in an osteoporosis-induced animal model
| العنوان: | Bovine colostrum supplementation improves bone metabolism in an osteoporosis-induced animal model |
|---|---|
| المؤلفون: | Kydonaki E.K., Freitas L., Fonseca B.M., Reguengo H., Simón C.R., Bastos A.R., Fernandes E.M., Canadas R.F., Oliveira J.M., Correlo V.M., Reis R.L., Vliora M., Gkiata P., Koutedakis Y., Ntina G., Pinto R., Carrillo A.E., Marques F., Amorim T. |
| المصدر: | Nutrients ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113420541&doi=10.3390%2fnu13092981&partnerID=40&md5=c11e6cab2ca90146a704aa4a99b5072aTest |
| سنة النشر: | 2021 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | fibroblast growth factor 2, messenger RNA, osteocalcin, osteoclast differentiation factor, receptor activator of nuclear factor kappa B, vasculotropin A, animal experiment, animal model, Article, bone density, bone metabolism, bone microarchitecture, bone strength, colostrum, controlled study, cortical bone, gene expression, in vivo study, nonhuman, ossification, osteolysis, osteoporosis, rat, real time polymerase chain reaction, supplementation, trabecular bone, animal, bone, bovine, dietary supplement |
| الوصف: | Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidec-tomized (ORX) rat models. Twenty-seven-week-old Wistar Han rats were randomly assigned as: (1) placebo control, (2) BC supplementation dose 1 (BC1: 0.5 g/day/OVX, 1 g/day/ORX), (3) BC sup-plementation dose 2 (BC2: 1 g/day/OVX, 1.5 g/day/ORX) and (4) BC supplementation dose 3 (BC3: 1.5 g/day/OVX, 2 g/day/ORX). Bone microarchitecture, strength, gene expression of VEGFA, FGF2, RANKL, RANK and OPG, and bone resorption/formation markers were assessed after four months of BC supplementation. Compared to the placebo, OVX rats in the BC1 group exhibited significantly higher cortical bone mineral content and trabecular bone mineral content (p < 0.01), while OVX rats in the BC3 group showed significantly higher trabecular bone mineral content (p <0.05). ORX rats receiving BC dose 2 demonstrated significantly higher levels of trabecular bone mineral content (p < 0.05). Serum osteocalcin in the ORX was pointedly higher in all BC supplementation groups than the placebo (BC1: p < 0.05; BC2, BC3: p < 0.001). Higher doses of BC induced significantly higher relative mRNA expression of OPG, VEGFA, FGF2 and RANKL (p < 0.05). BC supplementation improves bone metabolism of OVX and ORX rats, which might be associated with the activation of the VEGFA, FGF2 and RANKL/RANK/OPG pathways. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 20726643 |
| العلاقة: | http://hdl.handle.net/11615/75551Test |
| DOI: | 10.3390/nu13092981 |
| الإتاحة: | https://doi.org/10.3390/nu13092981Test http://hdl.handle.net/11615/75551Test |
| رقم الانضمام: | edsbas.85D544D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
|---|---|
| DOI: | 10.3390/nu13092981 |