التفاصيل البيبلوغرافية
| العنوان: |
SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism. |
| المؤلفون: |
McNamara, Jeffrey T., Huntington, Kelsey E., Borys, Samantha, Jayasuriya, Chathuraka T., Brossay, Laurent |
| المصدر: |
Scientific Reports; 10/8/2021, Vol. 11 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
WRIST, PROTEIN-tyrosine phosphatase, TROPISMS, BONE cells, DELETION mutation, STROMAL cells |
| مستخلص: |
Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in the wrist. Using a fate mapping system, we demonstrate that wrist tumor development correlates with increased frequency and numbers of non-hematopoietic lineage negative CD45 negative cells with a bone chondrocyte stromal cell precursor cell (BCSP) phenotype. Importantly, the BCSP subset has a history of CD4 expression and a marked wrist location tropism, explaining why the wrist is the main site of tumor development. Mechanistically, we found that in SHP-2 absence, SOX-9 is no longer regulated, leading to an uncontrolled proliferation of the BCSP subset. Altogether, these results identify a unique subset of chondrocyte precursors tightly regulated by SHP-2. These findings underscore the need for the development of methods to therapeutically target this subset of cells, which could potentially have an impact on treatment of SHP-2 dysfunction linked debilitating diseases. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder