A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis
| العنوان: | A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis |
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| المؤلفون: | Barr, AJ, Campbell, TM, Hopkinson, D, Kingsbury, SR, Bowes, MA, Conaghan, PG |
| المصدر: | Arthritis Research & Therapy |
| بيانات النشر: | BioMed Central, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | musculoskeletal diseases, Cartilage, Articular, Diagnostic Imaging, Immunology, Osteophyte, Arthralgia, Bone and Bones, Cross-Sectional Studies, Rheumatology, Bone Density, Osteoarthritis, Immunology and Allergy, Humans, Joints, Research Article |
| الوصف: | Introduction Bone is an integral part of the osteoarthritis (OA) process. We conducted a systematic literature review in order to understand the relationship between non-conventional radiographic imaging of subchondral bone, pain, structural pathology and joint replacement in peripheral joint OA. Methods A search of the Medline, EMBASE and Cochrane library databases was performed for original articles reporting association between non-conventional radiographic imaging-assessed subchondral bone pathologies and joint replacement, pain or structural progression in knee, hip, hand, ankle and foot OA. Each association was qualitatively characterised by a synthesis of the data from each analysis based upon study design, adequacy of covariate adjustment and quality scoring. Results In total 2456 abstracts were screened and 139 papers were included (70 cross-sectional, 71 longitudinal analyses; 116 knee, 15 hip, six hand, two ankle and involved 113 MRI, eight DXA, four CT, eight scintigraphic and eight 2D shape analyses). BMLs, osteophytes and bone shape were independently associated with structural progression or joint replacement. BMLs and bone shape were independently associated with longitudinal change in pain and incident frequent knee pain respectively. Conclusion Subchondral bone features have independent associations with structural progression, pain and joint replacement in peripheral OA in the hip and hand but especially in the knee. For peripheral OA sites other than the knee, there are fewer associations and independent associations of bone pathologies with these important OA outcomes which may reflect fewer studies; for example the foot and ankle were poorly studied. Subchondral OA bone appears to be a relevant therapeutic target. Systematic review PROSPERO registration number: CRD 42013005009 Electronic supplementary material The online version of this article (doi:10.1186/s13075-015-0735-x) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1478-6362 1478-6354 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8efb90c825888466b03ca733754a356cTest http://europepmc.org/articles/PMC4548899Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....8efb90c825888466b03ca733754a356c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14786362 14786354 |
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