التفاصيل البيبلوغرافية
| العنوان: |
Predictors of Time-in-Range (70-180 mg/dL) Achieved Using a Closed-Loop Control System. |
| المؤلفون: |
Schoelwer, Melissa J1 (AUTHOR), Kanapka, Lauren G2 (AUTHOR), Wadwa, R Paul3 (AUTHOR), Breton, Marc D1 (AUTHOR), Ruedy, Katrina J2 (AUTHOR), Ekhlaspour, Laya4 (AUTHOR), Forlenza, Gregory P3 (AUTHOR), Cobry, Erin C3 (AUTHOR), Messer, Laurel H3 (AUTHOR), Cengiz, Eda5 (AUTHOR), Jost, Emily3 (AUTHOR), Carria, Lori5 (AUTHOR), Emory, Emma1 (AUTHOR), Hsu, Liana J4 (AUTHOR), Weinzimer, Stuart A5 (AUTHOR), Buckingham, Bruce A4 (AUTHOR), Lal, Rayhan A4 (AUTHOR), Oliveri, Mary Clancy1 (AUTHOR), Kollman, Craig C1 (AUTHOR), Dokken, Betsy B6 (AUTHOR) |
| المصدر: |
Diabetes Technology & Therapeutics. Jul2021, Vol. 23 Issue 7, p475-481. 7p. |
| مصطلحات موضوعية: |
*CLOSED loop systems, *FORECASTING, *TYPE 1 diabetes, *GLYCEMIC control, *BODY weight, *INSULIN therapy, *RESEARCH, *BLOOD sugar monitoring, *RESEARCH methodology, *HYPOGLYCEMIC agents, *BLOOD sugar, *EVALUATION research, *COMPARATIVE studies, *INSULIN pumps, *RESEARCH funding |
| مستخلص: |
Background: Studies of closed-loop control (CLC) in patients with type 1 diabetes (T1D) consistently demonstrate improvements in glycemic control as measured by increased time-in-range (TIR) 70-180 mg/dL. However, clinical predictors of TIR in users of CLC systems are needed. Materials and Methods: We analyzed data from 100 children aged 6-13 years with T1D using the Tandem Control-IQ CLC system during a randomized trial or subsequent extension phase. Continuous glucose monitor data were collected at baseline and during 12-16 weeks of CLC use. Participants were stratified into quartiles of TIR on CLC to compare clinical characteristics. Results: TIR for those in the first, second, third, and fourth quartiles was 54%, 65%, 71%, and 78%, respectively. Lower baseline TIR was associated with lower TIR on CLC (r = 0.69, P < 0.001). However, lower baseline TIR was also associated with greater improvement in TIR on CLC (r = -0.81, P < 0.001). During CLC, participants in the highest versus lowest TIR-quartile administered more user-initiated boluses daily (8.5 ± 2.8 vs. 5.8 ± 2.6, P < 0.001) and received fewer automated boluses (3.5 ± 1.0 vs. 6.0 ± 1.6, P < 0.001). Participants in the lowest (vs. the highest) TIR-quartile received more insulin per body weight (1.13 ± 0.27 vs. 0.87 ± 0.20 U/kg/d, P = 0.008). However, in a multivariate model adjusting for baseline TIR, user-initiated boluses and insulin-per-body-weight were no longer significant. Conclusions: Higher baseline TIR is the strongest predictor of TIR on CLC in children with T1D. However, lower baseline TIR is associated with the greatest improvement in TIR. As with open-loop systems, user engagement is important for optimal glycemic control. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
