التفاصيل البيبلوغرافية
| العنوان: |
Whole Genome Sequencing Analysis of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele |
| المؤلفون: |
Zhang, Xinruo, Brody, Jennifer A., Graff, Mariaelisa, Highland, Heather M., Chami, Nathalie, Xu, Hanfei, Wang, Zhe, Ferrier, Kendra, Chittoor, Geetha, Josyula, Navya S., Li, Xihao, Li, Zilin, Allison, Matthew A., Becker, Diane M., Bielak, Lawrence F., Bis, Joshua C., Boorgula, Meher Preethi, Bowden, Donald W., Broome, Jai G., Buth, Erin J., Carlson, Christopher S., Chang, Kyong-Mi, Chavan, Sameer, Chiu, Yen-Feng, Chuang, Lee-Ming, Conomos, Matthew P., DeMeo, Dawn L., Du, Margaret, Duggirala, Ravindranath, Eng, Celeste, Fohner, Alison E., Freedman, Barry I., Garrett, Melanie E., Guo, Xiuqing, Haiman, Chris, Heavner, Benjamin D., Hidalgo, Bertha, Hixson, James E., Ho, Yuk-Lam, Hobbs, Brian D., Hu, Donglei, Hui, Qin, Hwu, Chii-Min, Jackson, Rebecca D., Jain, Deepti, Kalyani, Rita R., Kardia, Sharon L. R., Kelly, Tanika N., Lange, Ethan M., LeNoir, Michael, Li, Changwei, Marchand, Loic Le, McDonald, Merry-Lynn N., McHugh, Caitlin P., Morrison, Alanna C., Naseri, Take, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, O'Connell, Jeffrey, O'Donnell, Christopher J., Palmer, Nicholette D., Pankow, James S., Perry, James A., Peters, Ulrike, Preuss, Michael H., Rao, D. C., Regan, Elizabeth A., Reupena, Sefuiva M., Roden, Dan M., Rodriguez-Santana, Jose, Sitlani, Colleen M., Smith, Jennifer A., Tiwari, Hemant K., Vasan, Ramachandran S., Wang, Zeyuan, Weeks, Daniel E., Wessel, Jennifer, Wiggins, Kerri L., Wilkens, Lynne R., Wilson, Peter W. F., Yanek, Lisa R., Yoneda, Zachary T., Zhao, Wei, Zöllner, Sebastian, Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Blangero, John, Boerwinkle, Eric, Burchard, Esteban G., Carson, April P., Chasman, Daniel I., Chen, Yii-Der Ida, Curran, Joanne E., Fornage, Myriam, Gordeuk, Victor R., He, Jiang, Heckbert, Susan R., Hou, Lifang, Irvin, Marguerite R., Kooperberg, Charles, Minster, Ryan L., Mitchell, Braxton D., Nouraie, Mehdi, Psaty, Bruce M., Raffield, Laura M., Reiner, Alexander P., Rich, Stephen S., Rotter, Jerome I., Shoemaker, M. Benjamin, Smith, Nicholas L., Taylor, Kent D., Telen, Marilyn J., Weiss, Scott T., Zhang, Yingze, Heard-Costa, Nancy, Sun, Yan V., Lin, Xihong, Cupples, L. Adrienne, Lange, Leslie A., Liu, Ching-Ti, Loos, Ruth J. F., North, Kari E., Justice, Anne E. |
| المساهمون: |
Biostatistics and Health Data Science, School of Medicine |
| المصدر: |
PMC |
| بيانات النشر: |
medRxiv |
| سنة النشر: |
2023 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
Obesity, Mortality, Body mass index (BMI), Personalized medicine |
| الوصف: |
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P < 5 × 10−9). Notably, we identified and replicated a novel low frequency single nucleotide polymorphism (SNP) in MTMR3 that was common in individuals of African descent. Using a diverse study population, we further identified two novel secondary signals in known BMI loci and pinpointed two likely causal variants in the POC5 and DMD loci. Our work demonstrates the benefits of combining WGS and diverse cohorts in expanding current catalog of variants and genes confer risk for obesity, bringing us one step closer to personalized medicine. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Zhang X, Brody JA, Graff M, et al. WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE. Preprint. medRxiv. 2023;2023.08.21.23293271. Published 2023 Aug 22. doi:10.1101/2023.08.21.23293271; https://hdl.handle.net/1805/39289Test |
| الإتاحة: |
https://doi.org/10.1101/2023.08.21.23293271Test
https://hdl.handle.net/1805/39289Test |
| حقوق: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.8239C592 |
| قاعدة البيانات: |
BASE |
