التفاصيل البيبلوغرافية
| العنوان: |
Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment. |
| المؤلفون: |
Tientcheu, Leopold D.1,2,3 tientcheuleo@gmail.com, Haks, Mariëlle C.4, Agbla, Schadrac C.1,5, Sutherland, Jayne S.1, Adetifa, Ifedayo M.6,7, Donkor, Simon1, Quinten, Edwin4, Daramy, Mohammed1, Antonio, Martin1,8,9, Kampmann, Beate1, Ottenhoff, Tom H. M.4, Dockrell, Hazel M.2, Ota, Martin O.1,10 |
| المصدر: |
PLoS Neglected Tropical Diseases. 5/18/2016, Vol. 10 Issue 5, p1-20. 20p. |
| مصطلحات موضوعية: |
*MYCOBACTERIUM tuberculosis, *IMMUNE response, *MYCOBACTERIAL diseases, *LUNG diseases, *MEDICAL care |
| مستخلص: |
Epidemiological differences exist between Mycobacterium africanum (Maf)- and Mycobacterium tuberculosis (Mtb)-infected patients, but to date, contributing host factors have not been characterised. We analysed clinical outcomes, as well as soluble markers and gene expression profiles in unstimulated, and ESAT6/CFP-10-, whole-Maf- and Mtb-stimulated blood samples of 26 Maf- and 49 Mtb-HIV-negative tuberculosis patients before, and after 2 and 6 months of anti-tuberculosis therapy. Before treatment, both groups had similar clinical parameters, but differed in few cytokines concentration and gene expression profiles. Following treatment the body mass index, skinfold thickness and chest X-ray scores showed greater improvement in the Mtb- compared to Maf-infected patients, after adjusting for age, sex and ethnicity (p = 0.02; 0.04 and 0.007, respectively). In addition, in unstimulated blood, IL-12p70, IL12A and TLR9 were significantly higher in Maf-infected patients, while IL-15, IL-8 and MIP-1α were higher in Mtb-infected patients. Overnight stimulation with ESAT-6/CFP-10 induced significantly higher levels of IFN-γ and TNF-α production, as well as gene expression of CCL4, IL1B and TLR4 in Mtb- compared to Maf-infected patients. Our study confirms differences in clinical features and immune genes expression and concentration of proteins associated with inflammatory processes between Mtb- and Maf-infected patients following anti-tuberculosis treatment These findings have public health implications for treatment regimens, and biomarkers for tuberculosis diagnosis and susceptibility. [ABSTRACT FROM AUTHOR] |
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