التفاصيل البيبلوغرافية
| العنوان: |
Antibiotic body burden of elderly Chinese population and health risk assessment: A human biomonitoring-based study. |
| المؤلفون: |
Zhu, Yitian, Liu, Kaiyong, Zhang, Jingjing, Liu, Xinji, Yang, Linsheng, Wei, Rong, Wang, Sufang, Zhang, Dongmei, Xie, Shaoyu, Tao, Fangbiao |
| المصدر: |
Environmental Pollution; Jan2020, Vol. 256, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
HEALTH risk assessment, BODY burden, CIPROFLOXACIN, VETERINARY drugs, TANDEM mass spectrometry, POPULATION health, HUMAN experimentation, ANTIBIOTICS |
| مصطلحات جغرافية: |
ANHUI Sheng (China) |
| مستخلص: |
Recently, the widespread use of antibiotic has raised concerns about the potential health risks associated with their microbiological effect. In the present study, we investigated 990 elderly individuals (age ≥ 60 years) from the Cohort of Elderly Health and Environment Controllable Factors in West Anhui, China. A total of 45 representative antibiotics and two antibiotic metabolites were monitored in urine samples through liquid chromatography electrospray tandem mass spectrometry. The results revealed that 34 antibiotics were detected in 93.0% of all urine samples and the detection frequencies of each antibiotic varied between 0.2% and 35.5%. The overall detection frequencies of seven human antibiotics (HAs), 10 veterinary antibiotics (VAs), three antibiotics preferred as HAs (PHAs), and 14 preferred as VAs (PVAs) in urines were 27.4%, 62.9%, 30.9% and 72.7%, respectively. Notably, the samples with concentrations of six PVAs (sulfamethoxazole, trimethoprim, oxytetracycline, danofloxacin, norfloxacin and lincomycin) above 5000 ng/mL accounted for 1.7% of all urine samples. Additionally, in 62.7% of urine samples, the total antibiotic concentration was in the range of the limits of detection to 20.0 ng/mL. Furthermore, the elderly individuals with the sum of estimated daily intakes of VAs and PVAs more than 1 μg/kg/day accounted for 15.2% of all participants, and a health risk related to change in gut microbiota under antibiotic stimulation was expected in 6.7% of the elderly individuals. Especially, ciprofloxacin was the foremost contributor to the health risk, and its hazard quotient value was more than one in 3.5% of all subjects. Taken together, the elderly Chinese people were extensively exposed to VAs, and some elderly individuals may have a health risk associated with dysbiosis of the gut microbiota. Image 1 • Thirty-four antibiotics were detected in urines of 990 elderly from the Elderly Health and Environment Risk Factor cohort. • Fourteen antibiotics preferred for veterinary use were found in 72.7% of the elderly urines. • A higher detection frequency of the antibiotics preferred for veterinary use in males than in females. • Ciprofloxacin was the foremost contributor to the health risk in 3.5% of all subjects. • A health risk related to gut microbiota was revealed in 6.7% of the elderly. 34 antibiotics were detected in 93% urines of 990 elderly and health risk related to gut microbiota was revealed in 6.7% of the elderly. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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