التفاصيل البيبلوغرافية
العنوان:
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
المؤلفون:
Ridker, P. M. , Revkin, J. , Amarenco, P. , Brunell, R. , Civeira, F. , Flather, M. , Glynn, R. J. , Gregoire, J. , Jukema, J. W. , Karpov, Y. , Kastelein, J. J. P. , Koenig, W. , Lorenzatti, A. , Manga, P. , Masiukiewicz, U. , Miller, M. , Mosterd, A. , Murin, J. , Nicolau, J. C. , Nissen, S. , Ponikowski, P. , Santos, R. D. , Schwartz, P. F. , Soran, H. , White, H. , Wright, R. S. , Vrablik, M. , Yunis, C. , Shear, C. L. , Tardif , Conde D, J. -C. , Colquhoun, D , Missault, L , Grégoire, J , Gao, R , Urina, M , Solar, M , Jensen, Hk , Grobbee, D , Savolainen, M , Schiele, Fn , Montalescot, G , Edes, I , Blake, G , Lotan, C , Maggioni, A , Savonitto, S , Lee, Cw , Leiva Pons JL , Dan, Ga , Cortada, Jb , Mellbin, L , Kahan, T , Noble, S , Hwang, Jj , Sritara, P , Tökgozoğlu, L , Tarasenko, L , Borer, Js , Black, H , Carmena, R , Furie, Kl , Mcmurray, J , Neaton, J , Zannad, F , O’Neill, B , Welty, F , Mcnamara, R , Chun, H , Abbott, Jd , Jacoby, D , Mcpherson, C , Jadbabaie, F , Pinto, D , Mccullough, L , Silverman, Ie , Sansing, Lh , Dearborn-Tomazos, J , Foody, J , Schindler, J , Piazza, G , Chakrabarti, A , Pride, Y , Gelfand, E , Baultrukonis, D , Chaudhuri, S , Frederich, R , Johnson, M , Mridha, K , Powell, C , Wang, E , Wei, C , Anderson, P , Buonanno, M , Epsley, C , Evans, B , Frolova, M , Goetsch, M , Hessinger, D , Ikehara, E , Ivanac, K , Kizko, J , Le, K , McNally-Dufort, C , Morocco, T , Nadkarni, S , Nissen, T , Nye, R , Pak, R , Pence, D , Redifer, P , Schwartz, W , Sattler, C , Schade, R , Sullivan, B , Wegner, J , Alvarez, Ca , Budassi, N , Vogel, Dr , Avaca, H , Conde, Dg , Estol, Cc , Gelersztein, E , Glenny, Ja , Hershson, Ar , Bruno, Rl , Maffei, Le , Soler, Jm , Zaidman, Cj , Carnero, Gs , Colombo, Hr , Jure, Ho , Luquez, Ha , Ramos, Hr , Resk, Jh , Rusculleda, Mm , Ulla, Mr , Caccavo, A , Farias, Ef , Wenetz, Lm , Cabella, Pr , Cuadrado, Ja , Chahin, M , Mackinnon, Ij , Zarandon, Rb , Schmidberg, J , Fernandez, Aa , Montana, O , Codutti, Or , Gorosito, Vm , Maldonado, N , Sala, J , De La Fuente RA , Casabella, Te , Di Gennaro JP , Guerrero, Ra , Alvarez, Ms , Berli, M , Botta, Ce , Montenegro, Ee , Vico, Ml , Begg, A , Lehman, R , Gilfillan, Cp , D'Emden, M , Markovic, Tp , Sullivan, D , Aroney, C , Stranks, Sn , Crimmins, Ds , Arstall, M , Van Gaal, W , Davis, T , Aylward, Pe , Amerena, J , William, M , Proietto, J , Purnell, Pw , Singh, B , Arya, Kw , Dart, Am , Thompson, P , Davis, Sm , Carroll, Pa , De Looze, F , Jayasinghe, R , Bhindi, R , Buysschaert, I , Sarens, T , van de Borne, P , Scott, Bp , Roosen, J , Cools, F , Missault, Lh , Debroye, C , Schoors, Df , Hollanders, G , Schroe, Hh , De Sutter, J , Hermans, K , Carlier, M , van Landegem, P , Verwerft, J , Mulleners, T , Delforge, Md , Soufflet, V , Elegeert, I , Descamps, Os , Janssens, S , Lemmens, Rc , Desfontaines, P , Scheen, A , Heijmans, S , Capiau, L , Vervoort, G , Carlier, Sg , Faes, D , Alzand, B , Keuleers, S , De Wolf, L , Thoeng, J , De Bruyne, L , de Santos MO , Felicio, Js , Areas, Ca , Figueiredo, El , Michalaros, Yl , Neuenschwander, Fc , Reis, G , Saad, Ja , Kormann, Ap , Nascimento, Cv , Precoma, Db , Abib, E Jr , dos Santos FR , Mello, Yg , Saraiva, Jf , Rech, Rl , Cerci, R , Fortes, Ja , Rossi, Pr , de Lima, e Silva FA , Hissa, M , Silva, Rp , de Souza WK , Guimarães Filho FV , Mangili, Oc , de Oliveira Paiva MS , Tumelero, R , Abrantes, Ja , Caramori, Pr , Dutra, Op , Leaes, Pe , Manenti, Er , Polanczyk, Ca , Bandeira, e Farias FA , de Moraes Junior JB , Russo, La , Alves AR Jr , Dracoulakis, Md , Ritt, Le , Saporito, Wf , Herdy, Ah , Maia, Ln , Sternieri, Mv , Ayoub, Jc , Bianco, Ht , da Costa FA , Eliaschewitz, Fg , Fonseca, Fa , Nakandakare, Er , Bonansea, Tc , Castro, Nm , de Barros, e Silva PG , Smith, P , Botelho, Rv , Resende, Es , Barbieri, Ds , Hernandes, Me , Bajaj, H , Beaudry, P , Berlingieri, Jc , Salter, Tj , Ajala, B , Anderson, Tj , Nanji, A , Ross, S , Pandey, S , Desrosiers, D , Gaudet, D , Moran, G , Csanadi, Ma , St-Amour, E , Cusimano, S , Halperin, Fa , Babapulle, M , Vizel, S , Petrella, J , Spence, Jd , Gupta, N , Tellier, G , Bourgeois, R , Gregóire, Jc , Wesson, T , Zadra, R , Twum-Barima, Dy , Cha, Jy , Hartleib, Mc , Bergeron, J , Chouinard, G , Mcpherson, Tp , Searles, G , Peterson, Sr , Mukherjee, A , Lepage, S , Conway, Jr , Kouz, Sm , Dion, D , Pesant, Y , Cheung, Ss , Goldenberg, Rm , Aronson, R , Gupta, Ak , O’Mahoney, M , Pliamm, L , Teitelbaum, I , Hoag, Gn , Nadra, Ij , Yared, Z , Yao, Lc , Nguyen, T , Saunders, Kk , Potthoff, S , Varleta, P , Assef, V , Godoy, Jg , Olivares, C , Roman, O , Vejar, M , Montecinos, H , Pincetti, C , Li, Y , Wang, D , Li, J , Yang, X , Du, Y , Wang, G , Yang, P , Zhang, X , Xu, P , Zhao, Y , Chen, J , Li, S , Li, W , Zhang, L , Zhu, Y , Zhang, Y , Zhou, C , Wang, Y , Liu, F , Ma, Y , Ti, Z , Zeng, X , Zhou, Y , Cui, G , Li, D , Xue, L , Jiang, J , Lian, Y , He, Y , Mendoza, Ja , Bonfanti, Ja , Dada, Fa , Urina-Triana, Ma , Rodriguez, Wr , Sanchez, Ml , Lozno, Hy , Triana, Eh , Arambula, Rm , Rico-Carrillo, Ae , Gallo, Hj , Catano, Js , Jattin, Fg , Plazas, Ja , Gomez, Je , Botero-Lopez, R , Gomez, Ni , Munoz, Cf , Pelaez, Sv , Eraso, Am , Goyes, Ar , Elbl, L , Fiserova, N , Vesely, J , Wasserburger, B , Blaha, V , Vojacek, J , Maskova, P , Hutyra, M , Vrkoc, J , Hala, T , Vodnansky, P , Bocek, P , Cifkova, R , Bufka, V , Ceska, R , Machkova, M , Zidkova, E , Lukac, M , Mikusova, T , Kellnerova, I , Kuchar, L , Ferkl, R , Cech, V , Zemek, S , Monhart, Z , Davidsen, F , Joensen, A , Lihn, As , Rasmussen, Tk , Wiggers, H , Lindgren, Lm , Schmidt, U , Galatius, S , Sillesen, H , Bronnum Schou, J , Thomsen, Kk , Urhammer, S , Jeppensen, J , Schou, M , May, O , Steffensen, R , Nielsen, Wb , Nielesen, T , Jepsen, Jm , Rai, A , Sykulski, R , Andersen, Lt , Rickers, H , Frost, L , Lomholdt, J , Egstrup, K , Wermuth, S , Klausen, L , Lassus, J , Palomaki, A , Khari, J , Tatlisumak, T , Kekki, S , Vanttinen, E , Strandberg, A , Valtonen, M , Sia, Sm , Nerg, O , Puhakka, M , Strand, J , Timonen, M , Levola, J , Arstila, L , Taurio, J , Kantola, I , Suomi, J , Humaloja, K , Askonen, K , Schiele, F , Sibon, I , Zemour, G , Goube, P , Petit, C , Chati, Z , Range, G , Rabahi, F , Rihani, R , Bergerot, C , Roubille, F , Boye, A , Probst, V , Ferrari, E , Cayla, G , Thouvenot, E , Delarche, N , Couffinhal, T , Coisne, D , Paillard, F , Elbaz, M , Decoulx, E , Angoulvant, D , Agraou, B , Caudmont, S , Berrouschot, J , Lauer, B , Schoell, I , Trenk, D , Derwahl, Km , Khariouzov, A , Proepper, F , Stawowy, P , Da Stephan, U , Stoessel, J , Voehringer, Hf , Dorsel, T , Stellbrink, C , Rinke, A , Northroff, J , Bourhaial, H , Stratmann, M , Wetzel, T , Axthelm, C , Guenzel, A , Weigmann, I , Faghih, M , Hagemann, D , Schaefer, A , Weber, D , Luedemann, J , Contzen, C , Kornmann, Mo , Winkelmann, B , Simon, J , Felix, S , Brauer, C , Laufs, U , Schmidt, E , Marten, I , Licka, M , Heisters, J , Appel, Kf , Kleinecke-Pohl, U , Klein, C , von Hodenberg EF , Maus, O , Sigal, H , Taeschner, H , Schwimmbeck, P , Lemke, B , Perings, C , Illies, G , Pfuetzner, A , Salbach, P , Hengstenberg, C , Kohler, A , Mudra, H , Behnke, T , Baar, M , Jeserich, M , Scholz, G , Naudts, I , Voller, H , Herrmann, Hj , von Engelhardt CB , Gerke, S , Pohlmeier, L , Schaufele, T , Woehrle, J , Al-Zoebi, A , Horacek, T , Peterfai, E , Kemeny, V , Lakatos, F , Bod, E , Andrassy, P , Andreka, P , Balo, T , Davidovits, Z , Laszlo, Z , Nagy, K , Papp, A , Somogyi, A , Toldy-Schedel, E , Vertes, A , Voros, P , Paragh, G , Martyin, T , Hajdu, C , Deak, L , Farago, K , Nagy, A , Kirschner, R , Koszegi, Z , Zilahi, Z , Toth, K , Wittmann, I , Bajcsi, D , Reiber, I , Toth, L , Benczur, B , Nagy, L , Sydo, T , Lupkovics, G , Oroszlan, T , Crean, P , Mahon, Ng , Mcadam, B , Macneill, B , Katz, A , Tsalihin, D , Vazan, A , Eitan, A , Lewis, Bs , Gavish, D , Wainstein, J , Mosenzon, O , Mosseri, M , Vishlitzky, V , Atar, S , Nseir, Wb , Brenner, H , Elis, A , Fuchs, S , Shimon, I , Solodky, A , Goldhaber, A , Tanne, D , Knobler, H , Kracoff, Oh , Hussein, O , Auriel, E , Chorin, E , Sharir, T , Bitzur, R , Shechter, M , Antonicelli, R , Franceschini, E , Porcu, M , Sesti, G , Maggiolini, S , Salvioni, A , Filardi, Pp , Trimarco, B , Averna, M , Pasqualini, L , Pirro, M , Pantaleoni, M , Piovaccari, G , Arca, M , Fedele, Francesco , Roncon, L , Anselmi, M , Sganzerla, P , Morocutti, G , Bonora, E , Dimas, Al , Esperon, Ga , Morales-Villegas, E , Isunza, Jm , Beltran, Lg , Molina, Ca , Garcia, Dk , Ruiz, La , Reyna, Ls , De los Rios Ibarra MO , Soto, Jr , Gonzalez-Ortiz, M , Herrera-Marmolejo, M , Ramos, Sa , Ramos-Lopez, Ga , Stobschinski, Ca , Aguilarsalinas, Ca , Alpizar-Salazar, M , Jimenez-Sanchez, M , Sanchez Mijangos JH , Elizondo Moreno ER , Garcia Castillo, A , Garcia Hernandez PA , Gonzalez-Gonzalez, Jg , Riojas Charles CM , Valdez Lopez HG , Nuriulu Escobar PL , Lechuga Martin del Campo, A , Castro Montes BE , Mendez Bucio, A , Rodriguez-Briones, I , Torre Amione, G , Violante Ortiz, R , Luna Ceballos RI , Lopez Rosas, E , Bax, Wa , Alhakim, M , van de Wiel, A , Liem, Ss , Groutars, Rg , Herrman, Jp , Hovingh, Gk , van de Wetering ML , van Royen, N , Groenemeijer, Be , Hoedemaker, G , Schaap, J , Ronner, E , Angun, M , Mairuhu, At , Van Alem AP , Martens, Fm , Heijmeriks, Ja , van Hal JM , Schoofs, Mw , den Hartog FR , Kentgens, S , Post, Jc , Louwerenburg, Jw , van Rossum, P , Viergever, Ep , Donders, Sh , Kamphuisen, Pw , van Beek, E , Nijmeijer, R , Lenderink, T , Schreuder, T , Kuijper, Af , The, Sh , Van het Hof-Wiersma JJ , Tichelaar, P , Westerndorp, I , Breedveld, Rw , Karalis, I , Romer, Tj , Bogaard, K , Van Koningsbruggen, P , Kroon, Aa , Hoogslag, Pa , Rensing, Bj , Cramer, E , Remmen, Jj , Riksen, Np , Bokern, Mj , Cabezas, Mc , Mulder, H , Nierop, Pr , van Kempen WW , Zoet-Nugteren, Sk , van Daele ME , Swart, Hp , van der Zwaan CT , Hermans, Wr , Magro, M , van de Wal RM , Hassink, Rj , Visseren, F , Veenendaal, A , De Nooijer, C , Troquay, Rp , Imholz, Bp , van der Meer, P , Visser, Rp , van Leendert RJ , Gosselink, Ma , Baker, J , Benatar, Jr , Kerr, J , Pryke, Jr , Scott, Rs , Millar-Corte, Gd , Williams, M , Montgomery, B , Venter, Dj , Ternouth, If , Decaigney, Sc , Hart, Hh , Corin, A , Garden, Pi , Sheahan, D , Harding, Sa , Korecki, J , Supronik, J , Styczkiewicz, M , Bijata-Bronisz, R , Rusicka, T , Walczak, M , Krolikowski, Z , Ostrowski, J , Lukaszewicz, M , Przekwas-Jaruchowska, M , Zieba, B , Miekus, P , Orkwiszewska-Nalewajko, A , Piepiorka, M , Kubalski, P , Wychota, K , Blach, E , Ochala, A , Okopien, B , Wronska, D , Janion, M , Czarnecka, D , Kolodziejczyk, J , Konieczynska, M , Landa, K , Mirek-Bryniarska, E , Necki, M , Pasternak, Da , Rozpondek, P , Trebacz, J , Walczewska, J , Sidor, M , Broncel, M , Drozdz, J , Kosmider, M , Saryusz-Wolska, M , Kucharska, D , Opalinska, E , Pijanowski, Z , Wozniak, I , Banaszkiewicz, K , Klecha, A , Horodecki, M , Piskorz-Wapinska, J , Kobielusz-Gembala, I , Kim, Mh , Kim, Dk , Cho, Br , Kim, Ks , Her, Sh , Lee, Sy , Rhee, My , Kim, K , Kang, Wc , Kim, Dh , Cho, Ys , Kim, Sh , Rim, Sj , Tahk, Sj , Jeon, Hk , Yoon, J , Mociran, M , Pop, Cf , Minescu, B , Andrei, Ld , Radoi, M , Calin, A , Ciomag, Rm , Copaci, I , Fruntelata, Ag , Popescu, M , Tivadar, S , Roman, G , Avram, Ri , Mistodie, Cv , Morosanu, M , Popa, Ar , Popescu, Ml , Popoviciu, Ms , Tase, A , Busegeanu, M , Popescu, A , Szilagyi, I , Sitterli-Natea, Cn , Maximov, Dm , Munteanu, M , Negrisanu, Gd , Kuzin, A , Popov, D , Shapovalova, J , Vishneva, E , Shutemova, E , Pasechnik, E , Bogdanov, E , Khasanov, N , Barbarash, Ol , Shangina, Oa , Tarasov, N , Solonev, O , Kosmacheva, E , Chernyatina, Ma , Ginzburg, M , Blokhin, A , Bulanova, N , Drapkina, Om , Gordeev, Ig , Libov, Ia , Lomakin, N , Panchenko, E , Shogenov, Zs , Zateyshchikov, D , Klein, G , Motylev, I , Belenkiy, Di , Demin, A , Nikolaev, Ky , Oleynikov, V , Zrazhevskiy, K , Katelnitskiy, I , Khaisheva, L , Aksentiev, S , Nedoshivin, A , Popova, Vb , Agafina, As , Ballyuzek, M , Baranova, E , Burova, N , Eryshev, S , Filippov, A , Goloshchekin, Bm , Konstantinov, V , Kostenko, Va , Simanenkov, Vi , Volkova, A , Duplyakov, D , Reshetko, O , Shvarts, Y , Kuznetsov, Va , Samoylova, Yg , Tolkacheva, V , Shalaev, Sv , Khokhlov, Al , Malygin, A , Shilkina, Np , Yakusevich, Vv , Margoczy, R , Zubek, V , Dzupina, A , Dubrava, J , Dulkova, K , Fabryova, L , Gaspar, L , Kamensky, G , Kokles, M , Raslova, K , Soosova, I , Stevlik, J , Strbova, J , Sumbal, J , Uhliar, R , Micik, J , Truban, J , Fedacko, J , Pastrnakova, E , Pella, D , Fazekas, F , Ambrovicova, V , Kycina, P , Martinka, E , Nociar, J , Belicova, M , Banik, M , Kanderkova, D , Hranai, M , Duris, T , Krahulec, B , Benacka, J , Vinanska, D , Roskova, E , Skripova, D , Macek, V , Vohnout, B , Buganova, I , Engelbrecht, Jm , Pretorius, Mm , Ebrahim, Io , Bayat, J , Ganesh, S , Ranjith, N , Coetzer, Tf , Jacovides, A , Distiller, La , Hellig, Fs , Engelbrecht, Iv , Mahomed, Aa , Blignault, Sc , Burgess, Lj , Kotze, Hj , van Nieuwenhuizen, E , Musungaie, Db , Emanuel, S , van der Walt, E , Pretorius, Ce , Roos, Js , Roux, Sm , Badat, Ae , Fouche, L , Vahed, Ya , Jansen van Resburg, D , van Zyl LJ , Soto Gonzalez, A , Diaz, Jl , Segura, T , Botella Serrano, M , Botas Rodrigues, J , Molto-Jorda, Jm , Dominguez Escribano JR , Sogorb Garri, F , Blanco Coronado JL , Gaztambide Saenz MS , Brotons Cuixart, C , Bruguera Cortada, J , Garcia-Moll Marimon, X , Gonzalbez Morgaez JD , Maisterra Santos, O , Roquer Gonzalez, J , Sobrino-Martinez, J , Chueca Fernandez JE , Narejos, S , Suarez Garcia, S , Perez Martinez, P , Figueras Camos, R , Medrano Martinez, V , Bellido Guerrero, D , Martinez Deben, F , Vila Belmonte, A , Mediavilla Garcia JD , Romero Hinojosa JA , Martorell Mateu, E , Cequier Fillat AR , Pinto Sala, X , Adroer Martori, R , Bueno Diez, M , Lopez Cano, C , Worner Diz, F , Gonzalez Juanatey, C , Alvarez-Sala Walther LA , De Dios Garcia Diaz, J , Garcia Puig, J , Jodar Gimeno, E , Plaza Perez, I , Suarez-Fernandez, C , Tunon, J , Zamorano Gomez JL , Brito Sanfiel MA , Escudier Villa JM , de Mora Martin, M , Dominguez Lopez, M , Hernandez Garcia JM , Tinahones Madueno FJ , Perez Paredes, M , Aracil Villar, J , Barreda Gonzalez MJ , Ripoll Vera TV , Tofe Povedano, S , Sanchez Alvarez, J , Martinez Via, L , Robles Iniesta, A , Masana, L , Vinyoles Bargallo, E , Calvo Gomez, C , Gonzalez Juanatey JR , Cruz Fernandez JM , De La Cuesta Mayor, C , Duran Garcia, S , Jimenez Hernandez MD , Morales Portillo, C , Muniz Grijalvo, O , De Castro, R , Taverna Llaurado, E , Pons Amate JM , Terns Riera, M , Civeira Murillo, F , Linderfalk, C , Curiac, D , Saldeen-Nilehn, K , Koskinen, P , Khalili, P , Tortensson, I , Lindholm, Cj , Luts, A , Koskinen, Pt , Gottsater, A , Persson, Be , Mooe, T , Larnefeldt, H , Boman, K , Crisby, M , Rasmanis, G , Tengmark, Bo , Witt, N , Hagstrom, E , Viklund, J , Muller, C , Mach, F , Burnier, M , Nanchen, D , Wuerzner, G , Banyai, M , Moccetti, T , Miserez, Ar , Bilz, S , Weber, K , Lai, Wt , Chang, Kc , Ueng, Kc , Tsai, Wc , Chiang, Ce , Hou, C , Pei, D , Krittayaphong, R , Kiatchoosakun, S , Srimahachota, S , Boonyavarakul, A , Jintapakorn, W , Gullu, H , Onrat, E , Erkan, Af , Demirci, D , Sari, R , Ceyhan, C , Ari, H , Araz, M , Degertekin, M , Goktekin, O , Uresin, Ay , Yigit, Z , Akdeniz, B , Comlekci, A , Kayikcioglu, M , Sahin, T , Ozcan, T , Durakoglugil, E , Asamoah-Owusu, N , Reed, R , Bakhai, A , Dixon, L , Sharma, R , Avornyo, Aa , Jones, Af , Lip, G , Clark, R , Banerjee, M , Wakeling, J , Arden, C , Blagden, Md , Walukiewica, P , Marshall, A , Maxwell, Tg , Gunstone, Ae , Kadr, Hh , Patle, R , Arif, I , Jhund, Ps , Mckaig, G , Douglas, F , Mierzejewski, L , Turner, W , Sathyapalan, T , Ivan, P , Manoj, A , Rice, S , Collier, Dj , Nair, Dr , Thom, S , Fiore, G , De Belder, M , Price, D , Sobolewska, J , Martin, S , Takhar, A , Moriarty, A , Kondagunta, V , Myhill, T , Gibson, Jm , Cecil, Jt , Halcox, J , Annamalai, N , Gorog, Da , Mccormack, T , Pegge, N , Field, A , Adams, F , Klein, Jj , Busch, Rs , Bretton, Em , Jaffrani, N , Salacata, A , Assadourian, A , Gogia, Hs , Dyke, Ck , Rubenfire, M , Essandoh, Lk , Welker, Ja , Ledesma, G , Lupovitch, S , Delgado, Jp , Hendrix, El , Quyyumi, Aa , Riesenberg, Ra , Robertson, Dg , Weinstein, Dl , Weiss, R , Casaubon, L , Gammon, Rs , Brar, Hs , Bittar, Gd , Guarnieri, Tt , Ince CS Jr , Jrquraishi, Am , Saeed, S , Albert, M , Sotolongo, Rp , Bernard, Jv , Karlsbergg, Rp , Lepor, Ne , Kirby, We , Mclean, B , Miller, Ap , Ovalle, F , Townsend, Jc , Beckett, Pl , Eaves, Wb , West, Sh , Kosinski, Ej , Zarich, Sw , Mahal, Ss , Maw, K , Maynard, Km , Chen, Jc , Gelormini, J , Gottlieb, Dw , Gabra, Nw , Narayan, P , Sparks, J , Field, Jc , Willits, Vl , O’Steen, Mb , Pasquini, Ja , Sensebrenner, Jw , Yarows, Sa , Hiotis, L , Jagielo, Tj , Levinson, Dj , Diller, Pm , Kereiakes, Dj , Turner, Ta , Vincent, S , Camp, Ad , Denker, Ps , Manning, Mb , Rocco, Mb , Stamps, Hb , Strader, Jr , Uusinarkaus, Kt , Kennett, Jd , Leichter, Sb , Mcneil, Dl , Schumacher, Dr , Chang, Ar , Ellison, Hs , Updegrove, Jd , Hamroff, Gs , Kay, Js , Marar, Ie , Flores, E , Saini, S , Abdullah, S , Berk, Mr , Fordan, S , Joshi, Ph , Mccullough, Pa , Reynolds, Rd , Rosenstock, J , Sachson, Ra , Shammas, N , Fishbein, Gj , Randall, Wj , Henderson, Da , Nash, Ml , Barker, Ba , Cohen, Ss , Seidman, B , Odekirk, Ll , Grillo, Rs , Martinez, Lm , Multani, P , Alwine, Lk , Mcgarvey, Jf , Mollerus, Me , Miller, Ab , Kotek, Lw , Changlani, M , Zavaro, Sh , Munoz, F , Mehta, Pm , Helm, Rj , Farhat, Nz , Farsad, R , Raoof, Tj , Shultz, Jh , Geohas, Jg , Allaw, Ma , Dela Llana, A , Gutmann, Je , Inzerello, At , Alappat, P , George, Ar , Haddad, Tm , Lillestol, Mj , Grodman, R , Peniston, Jh , Wadud, K , Garcia, B , Hamilton, Me , Lerman, S , Perloff, De , Graff, A , Saxena, S , Alvarado, Op , Malik, A , Reddy, Rd , Kinzfogl, G , Cornett, Gm , Norwood, Pc , Gilbert, Jm , Willis, Jg , Mcgrew, F , Sharma, S , Castro, Ma , Cucher, Fh , Altafullah, Im , Khurana, S , Knutson, Tj , Kinnaman, Sj , Stuckey, T , Pudi, Kk , Mayfield, Rk , Funk, Gs , Nixon, Wa , Dor, I , Boyett, Be , Srivastava, S , Elosegui, Am , Isserman, Sm , Cheek, Hb , Promisloff, Sd 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المساهمون:
Ridker, P., Revkin, J., Amarenco, P., Brunell, R., Curto, M., Civeira, F., Flather, M., Glynn, R., Gregoire, J., Jukema, J., Karpov, Y., Kastelein, J., Koenig, W., Lorenzatti, A., Manga, P., Masiukiewicz, U., Miller, M., Mosterd, A., Murin, J., Nicolau, J., Nissen, S., Ponikowski, P., Santos, R., Schwartz, P., Soran, H., White, H., Wright, R., Vrablik, M., Yunis, C., Shear, C., Tardif, J., SPIRE Cardiovascular Outcome Investigators, Averna, M., Brigham and Women's Hospital [Boston], Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Interne Geneeskunde, Ridker, P. M., Glynn, R. J., Jukema, J. W., Kastelein, J. J. P., Nicolau, J. C., Santos, R. D., Schwartz, P. F., Wright, R. S., Shear, C. L., Tardif, J. -C., SPIRE Cardiovascular Outcome Investigator, Perrone, Filardi, P, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, ACS - Pulmonary hypertension & thrombosis, ACS - Atherosclerosis & ischemic syndromes
المصدر:
The New England Journal of Medicine, 376, 16, pp. 1527-1539https://doi.org/10.1056/NEJMoa1701488Test
سنة النشر:
2017
مصطلحات موضوعية:
Male , STATIN THERAPY , Anticholesteremic Agents/adverse effects , Antibodie , Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] , Injections, Subcutaneous/adverse effects , 030204 cardiovascular system & hematology , Bococizumab , law.invention , PCSK9 , 0302 clinical medicine , Randomized controlled trial , law , Risk Factors , GENETIC-VARIANTS , Cardiovascular Disease , Monoclonal , Anticholesteremic Agent , 030212 general & internal medicine , Myocardial infarction , Treatment Failure , Humanized , Proprotein Convertase 9/antagonists & inhibitors , Medicine(all) , Antibodies , Antibodies, Monoclonal, Humanized , Anticholesteremic Agents , Cardiovascular Diseases , Cholesterol, LDL , Double-Blind Method , Female , Follow-Up Studies , Humans , Hypercholesterolemia , Injections, Subcutaneous , Lipids , Middle Aged , Proprotein Convertase 9 , Medicine (all) , PCSK9 Inhibitors , antibodies monoclonal humanized , anticholesteremic agents , cardiovascular diseases , cholesterol, LDL , double-blind method , female , follow-up studies , humans , hypercholesterolemia , injections, subcutaneous , lipids , male , middle aged , proprotein convertase 9 , risk factors , treatment failure , medicine (all) , Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] , General Medicine , Lipid , 3. Good health , LDL/blood , Multicenter Study , Cholesterol , TRIALS , Cholesterol, LDL/blood , Antibodies, Monoclonal, Humanized/adverse effects , Randomized Controlled Trial , subcutaneous , lipids (amino acids, peptides, and proteins) , Cardiovascular Diseases/prevention & control , REDUCING LIPIDS , Human , medicine.medical_specialty , animal structures , Hypercholesterolemia/drug therapy , Placebo , Injections, Subcutaneou , LDL , Injections , Follow-Up Studie , EVENTS , 03 medical and health sciences , Internal medicine , medicine , Journal Article , Comparative Study , METAANALYSIS , Alirocumab , business.industry , Unstable angina , Lipids/blood , Risk Factor , fungi , Antibodies/blood , ta3121 , medicine.disease , Surgery , Evolocumab , REDUCTION , Humanized/adverse effects , Subcutaneous/adverse effects , business , [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
الوصف:
Item does not contain fulltext BACKGROUND: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS: At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P/=70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P=0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of >/=100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P=0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P=0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P
وصف الملف:
application/pdf; image/pdf
تدمد:
0028-4793
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48145f0e532c28c7df2dafc05d62159Test https://hdl.handle.net/2066/182257Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....f48145f0e532c28c7df2dafc05d62159
قاعدة البيانات:
OpenAIRE
