دورية أكاديمية
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection
| العنوان: | A Neutrophil Timer Coordinates Immune Defense and Vascular Protection |
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| المؤلفون: | Adrover, Jose M, del Fresno, Carlos, Crainiciuc, Georgiana, Cuartero, Maria Isabel, Casanova-Acebes, Maria, Weiss, Linnea A, Huerga-Encabo, Hector, Silvestre-Roig, Carlos, Rossaint, Jan, Cossio, Itziar, Lechuga-Vieco, Ana V., Garcia-Prieto, Jaime, Gomez-Parrizas, Monica, Quintana, Juan A., Ballesteros, Ivan, Martin-Salamanca, Sandra, Aroca-Crevillen, Alejandra, Chong, Shu Zhen, Evrard, Maximilien, Balabanian, Karl, López, Jorge, Bidzhekov, Kiril, Bachelerie, Françoise, Abad-Santos, Francisco, Muñoz-Calleja, Cecilia, Zarbock, Alexander, Soehnlein, Oliver, Weber, Christian, Ng, Lai Guan, Lopez-Rodriguez, Cristina, Sancho, David, Moro, Maria Angeles, Ibáñez, Borja, Hidalgo, Andres |
| المساهمون: | Ministerio de Economía, Industria y Competitividad (España), Unión Europea. Comisión Europea, Unión Europea. Comisión Europea. European Research Council (ERC), Deutsche Forschungsgemeinschaft (Alemania), German Centre for Cardiovascular Research, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Fundación ProCNIC, Instituto de Salud Carlos III, Centro de Investigación Biomedica en Red - CIBER |
| سنة النشر: | 2019 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Bmal1, CXCR2, CXCR4, Candida albicans, Neutrophil, Circadian clock, Infection, Inflammation, Myocardial infarction, Neutrophil aging |
| الوصف: | Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting an efficient anti-microbial defense while preserving vascular health. Here, we identify a neutrophil-intrinsic program that enabled both. The gene Bmal1 regulated expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in the transcriptional and migratory properties of circulating neutrophils. These diurnal alterations, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted anti-microbial activity in tissues. Mice engineered for constitutive neutrophil aging became resistant to infection, but the persistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death. Thus, diurnal compartmentalization of neutrophils, driven by an internal timer, coordinates immune defense and vascular protection. ; We thank all members of the Hidalgo Lab for discussion and insightful comments; J.M. Ligos, R. Nieto, and M. Viton for help with sorting and cytometric analyses; I. Ortega and E. Santos for animal husbandry; D. Rico, M.J. Gomez, C. Torroja, and F. Sanchez-Cabo for insightful comments and help with transcriptomic analyses; V. Labrador, E. Arza, A.M. Santos, and the Microscopy Unit of the CNIC for help with microscopy; S. Aznar-Benitah, U. Albrecht, Q.-J. Meng, B. Staels, and H. Duez for the generous gift of mice; J.A. Enriquez and J. Avila for scientific insights; and J.M. Garcia and A. Diez de la Cortina for art. This study was supported by Intramural grants from A* STAR to L.G.N., BES-2013-065550 to J.M.A., BES-2010-032828 to M.C.-A, and JCI-2012-14147 to L.A.W (all from Ministerio de Economia, Industria y Competitividad; MEIC). Additional MEIC grants were SAF2014-61993-EXP to C.L.-R.; SAF2015-68632-R to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1074-7613 30709741 1097-4180 |
| العلاقة: | https://doi.org/10.1016/j.immuni.2019.01.002Test; info:eu-repo/grantAgreement/ES/SEV-2015-0505; info:eu-repo/grantAgreement/ES/BES-2013-065550; info:eu-repo/grantAgreement/ES/BES-2010-032828; info:eu-repo/grantAgreement/ES/JCI-2012-14147; info:eu-repo/grantAgreement/ES/SAF2014-61993-EXP; info:eu-repo/grantAgreement/ES/SAF2015-68632-R; info:eu-repo/grantAgreement/ES/SAF-2013-42920R; info:eu-repo/grantAgreement/ES/SAF2016-79040R; info:eu-repo/grantAgreement/EC/H2020/635122; info:eu-repo/grantAgreement/EC/H2020/725091; info:eu-repo/grantAgreement/EC/H2020/692511; info:eu-repo/grantAgreement/ES/PI13/01979; info:eu-repo/grantAgreement/ES/RD12/0042/0054; info:eu-repo/grantAgreement/ES/SAF2015-65607-R; info:eu-repo/grantAgreement/ES/SAF2013-49662-EXP; Immunity. 2019; 50(2):390-402; http://hdl.handle.net/20.500.12105/7864Test; Immunity |
| DOI: | 10.1016/j.immuni.2019.01.002 |
| الإتاحة: | https://doi.org/20.500.12105/7864Test https://doi.org/10.1016/j.immuni.2019.01.002Test https://hdl.handle.net/20.500.12105/7864Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.52BDE72A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10747613 30709741 10974180 |
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| DOI: | 10.1016/j.immuni.2019.01.002 |