Mannitol induces selective astroglial death in the CA1 region of the rat hippocampus following status epilepticus
| العنوان: | Mannitol induces selective astroglial death in the CA1 region of the rat hippocampus following status epilepticus |
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| المؤلفون: | Tae-Cheon Kang, Ah-Reum Ko |
| المصدر: | BMB Reports BMB REPORTS(48): 9 |
| بيانات النشر: | Korean Society for Biochemistry and Molecular Biology - BMB Reports, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Astroglial death, Blood-brain barrier, Epilepsy, Mannitol, Statusepilepticus, Male, medicine.medical_specialty, medicine.drug_class, Hippocampus, Brain Edema, Status epilepticus, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Status Epilepticus, Internal medicine, Piriform cortex, medicine, Animals, CA1 Region, Hippocampal, Molecular Biology, Cell Death, Chemistry, Dentate gyrus, General Medicine, medicine.disease, Osmotic diuretic, Rats, Astrogliosis, medicine.anatomical_structure, Endocrinology, nervous system, Astrocytes, Models, Animal, medicine.symptom, Research Article, medicine.drug |
| الوصف: | In the present study, we addressed the question of whether treatment with mannitol, an osmotic diuretic, affects astrogliovascular responses to status epilepticus (SE). In saline-treated animals, astrocytes exhibited reactive astrogliosis in the CA1-3 regions 2-4 days after SE. In the mannitol-treated animals, a large astroglial empty zone was observed in the CA1 region 2 days after SE. This astroglial loss was unrelated to vasogenic edema formation. There was no difference in SE-induced neuronal loss between saline- and mannitol-treated animals. Furthermore, mannitol treatment did not affect astroglial loss and vasogenic edema formation in the dentate gyrus and the piriform cortex. These findings suggest that mannitol treatment induces selective astroglial loss in the CA1 region independent of vasogenic edema formation following SE. These findings support the hypothesis that the susceptibility of astrocytes to SE is most likely due to the distinctive heterogeneity of astrocytes independent of hemodynamics. [BMB Reports 2015; 48(9): 507-512] |
| تدمد: | 1976-6696 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1ef0aeca7b581d456eddc28f53f8a0Test https://doi.org/10.5483/bmbrep.2015.48.9.013Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c1ef0aeca7b581d456eddc28f53f8a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19766696 |
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