التفاصيل البيبلوغرافية
| العنوان: |
Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study. |
| المؤلفون: |
Mahmud, Farid H., Clarke, Antoine B.M., Joachim, Kariym C., Assor, Esther, McDonald, Charlotte, Saibil, Fred, Lochnan, Heather A., Punthakee, Zubin, Parikh, Amish, Advani, Andrew, Shah, Baiju R., Perkins, Bruce A., Zuijdwijk, Caroline S., Mack, David R., Koltin, Dror, De Melo, Emilia N., Hsieh, Eugene, Mukerji, Geetha, Gilbert, Jeremy, Bax, Kevin |
| المصدر: |
Diabetes Care; Jul2020, Vol. 43 Issue 7, p1553-1556, 4p |
| مصطلحات موضوعية: |
TYPE 1 diabetes, CELIAC disease, TREATMENT effectiveness, GLUTEN-free diet, CELIAC disease diagnosis, BLOOD sugar analysis, CELIAC disease complications, AUTOANTIBODY analysis, AUTOANTIBODIES, RESEARCH, BIOPSY, BLOOD sugar monitoring, SERODIAGNOSIS, RESEARCH methodology, MEDICAL screening, INGESTION, BLOOD sugar, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, SYMPTOMS, DISEASE complications |
| مصطلحات جغرافية: |
CANADA |
| مستخلص: |
Objective: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.Research Design and Methods: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months.Results: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, N = 1,298] vs. 4.7% [95% CI 3.4-5.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P < 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7; P = 0.014) emerged with a GFD.Conclusions: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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