التفاصيل البيبلوغرافية
| العنوان: |
Factors related to the outcome of prophylactic platelet transfusions in patients with hematologic malignancies: an observational study. |
| المؤلفون: |
Seigeot, Audrey, Desmarets, Maxime, Rumpler, Anne, Leroux, Franck, Deconinck, Eric, Monnet, Elisabeth, Bardiaux, Laurent |
| المصدر: |
Transfusion; Jun2018, Vol. 58 Issue 6, p1377-1387, 11p, 1 Diagram, 5 Charts |
| مصطلحات موضوعية: |
BLOOD platelet transfusion, THROMBOCYTOPENIA, HEMATOLOGIC malignancies, HEMATOLOGY, BLOOD coagulation disorders, BLOOD collection, BLOOD cell count, ABO blood group system, BLOOD irradiation, CLINICAL trials, PREVENTIVE medicine, MULTIVARIATE analysis, TREATMENT effectiveness, BLOOD grouping & crossmatching, PLATELET-rich plasma, THERAPEUTICS |
| مستخلص: |
Background: A better knowledge of the connections between platelet concentrate (PC) characteristics and transfusion outcomes in day-to-day practice would help improve the selection process of the most appropriate PC.Study Design and Methods: In this study of prophylactic platelet transfusions in patients with hematologic malignancies between 2002 and 2012, outcome criteria were corrected count increments (CCIs) and platelet transfusion intervals (TIs, in days). Studied characteristics were ABO matching status, platelet source, dose, storage duration, irradiation, washing, and transfusion sequence number (TSN). The analysis consisted of multivariable linear mixed-effects models with adjustments for patient diagnosis, sex, and type of treatment.Results: Overall, 869 patients and 6662 platelet transfusions were analyzed. For each day after the second day of storage, the CCI and TI decreased by 0.88 and 0.06 day, respectively. Compared to ABO-identical, transfusion with major ABO-incompatible PCs decreased the CCI and TI by 0.79 and 0.21 day, respectively. Platelet washing reduced the CCI and TI by 2.28 and 0.24 day, respectively. There was no significant association between platelet source or irradiation and CCI or TI. TI increased as the platelet dose per kg increased. Both CCI and TI decreased as the TSN increased.Conclusion: Transfusion outcomes were significantly related to several PC-related factors. Associations for ABO matching status and storage duration were stronger than previously reported. Taking into account such factors when selecting a PC for transfusion could be beneficial to the recipient. [ABSTRACT FROM AUTHOR] |
|
Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
