Anticipated basal insulin reduction to prevent exercise-induced hypoglycemia in adults and adolescents living with type 1 diabetes
| العنوان: | Anticipated basal insulin reduction to prevent exercise-induced hypoglycemia in adults and adolescents living with type 1 diabetes |
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| المؤلفون: | Tagougui, Semah, Legault, Laurent, Heyman, Elsa, Messier, Virginie, Suppere, Corinne, Potter, Kathryn J., Pigny, Pascal, Berthoin, Serge, Taleb, Nadine, Rabasa-Lhoret, Rémi |
| المساهمون: | Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, McGill University = Université McGill [Montréal, Canada], Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 (MSAP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group |
| المصدر: | Diabetes Technology and Therapeutics Diabetes Technology and Therapeutics, 2022, Diabetes Technology and Therapeutics, 24 (5), ⟨10.1089/dia.2021.0375⟩ |
| بيانات النشر: | HAL CCSD, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Cross-Over Studies, Adolescent, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Hypoglycemic Agents/therapeutic use, Blood Glucose/analysis, Hypoglycemia/etiology, Hypoglycemia, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Endocrinology, Insulin/therapeutic use, Humans, Hypoglycemic Agents, Insulin, Anticipated basal insulin reduction, Exercise-induced hypoglycemia, Insulin pump |
| الوصف: | Objective: We investigated the effect of two key timings for basal insulin rate reduction on exercise-induced glucose changes and explored the association between circulating insulin concentrations and muscle vasoreactivity. Research Design and Methods: Twenty adults and adolescents performed 60-min exercise sessions (ergocycle) at 60% VO2peak, 240 min after a standardized lunch. In a randomized order, we compared an 80% basal insulin reduction applied 40 min (T-40) or 90 min (T-90) before exercise onset. Near-infrared spectroscopy was used to investigate muscle hemodynamics at vastus lateralis. Glucose and insulin plasma concentrations were measured. Results: Reduction in plasma glucose (PG) level during exercise was attenuated during T-90 versus T-40 strategy (-0.89 ± 1.89 mmol/L vs. -2.17 ± 2.49 mmol/L, respectively; P = 0.09). Linear mixed model analysis showed that PG dropped by an additional 0.01 mM per minute in T-40 versus T-90 (time × strategy interaction, P |
| اللغة: | English |
| تدمد: | 0334-9489 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba6225a4c0d845eab1de3113f0e065eTest https://hal.univ-lille.fr/hal-04105968Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fba6225a4c0d845eab1de3113f0e065e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03349489 15209156 |
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