المؤلفون: Faggionato, Edoardo, Schiavon, Michele, Ekhlaspour, Laya, Buckingham, Bruce, Dalla Man, Chiara

المصدر: IEEE Transactions on Biomedical Engineering. 71(3)

مصطلحات موضوعية: Humans, Adult, Middle Aged, Glucose, Diabetes Mellitus, Type 1, Insulin Resistance, Blood Glucose, Blood Glucose Self-Monitoring, Bayes Theorem, Insulin, Hypoglycemic Agents

الوصف: OBJECTIVE: Modeling the effect of meal composition on glucose excursion would help in designing decision support systems (DSS) for type 1 diabetes (T1D) management. In fact, macronutrients differently affect post-prandial gastric retention (GR), rate of appearance (R[Formula: see text]), and insulin sensitivity (S[Formula: see text]). Such variables can be estimated, in inpatient settings, from plasma glucose (G) and insulin (I) data using the Oral glucose Minimal Model (OMM) coupled with a physiological model of glucose transit through the gastrointestinal tract (reference OMM, R-OMM). Here, we present a model able to estimate those quantities in daily-life conditions, using minimally-invasive (MI) technologies, and validate it against the R-OMM. METHODS: Forty-seven individuals with T1D (weight =78±13 kg, age =42±10 yr) underwent three 23-hour visits, during which G and I were frequently sampled while wearing continuous glucose monitoring (CGM) and insulin pump (IP). Using a Bayesian Maximum A Posteriori estimator, R-OMM was identified from plasma G and I measurements, and MI-OMM was identified from CGM and IP data. RESULTS: The MI-OMM fitted the CGM data well and provided precise parameter estimates. GR and R[Formula: see text] model parameters were not significantly different using the MI-OMM and R-OMM (p 0.05) and the correlation between the two S[Formula: see text] was satisfactory ( ρ =0.77). CONCLUSION: The MI-OMM is usable to estimate GR, R[Formula: see text], and S[Formula: see text] from data collected in real-life conditions with minimally-invasive technologies. SIGNIFICANCE: Applying MI-OMM to datasets where meal compositions are available will allow modeling the effect of each macronutrient on GR, R[Formula: see text], and S[Formula: see text]. DSS could finally exploit this information to improve diabetes management.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4zm3c05sTest

المؤلفون: Matveyenko, Aleksey V, Liuwantara, David, Gurlo, Tatyana, Kirakossian, David, Dalla Man, Chiara, Cobelli, Claudio, White, Morris F, Copps, Kyle D, Volpi, Elena, Fujita, Satoshi, Butler, Peter C

المصدر: Diabetes. 61(9)

مصطلحات موضوعية: Liver, Portal Vein, Animals, Dogs, Rats, Rats, Sprague-Dawley, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Insulin Resistance, Insulin, Glucokinase, Blood Glucose, Nerve Tissue Proteins, Signal Transduction, Male, Proto-Oncogene Proteins c-akt, Forkhead Transcription Factors, Insulin Receptor Substrate Proteins, Insulin Secretion, Diabetes Mellitus, Experimental, Type 2, Sprague-Dawley, Medical and Health Sciences, Endocrinology & Metabolism

الوصف: Insulin is secreted as discrete insulin secretory bursts at ~5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vein is important for hepatic insulin action and, therefore, presumably for hepatic insulin signaling. To test this, we examined hepatic insulin signaling in rat livers exposed to the same three patterns of portal vein insulin delivery by use of sequential liver biopsies in anesthetized rats. Intraportal delivery of insulin in a constant versus pulsatile pattern led to delayed and impaired activation of hepatic insulin receptor substrate (IRS)-1 and IRS-2 signaling, impaired activation of downstream insulin signaling effector molecules AKT and Foxo1, and decreased expression of glucokinase (Gck). We further established that hepatic Gck expression is decreased in the HIP rat model of T2DM, a defect that correlated with a progressive defect of pulsatile insulin secretion. We conclude that the physiological pulsatile pattern of insulin delivery is important in hepatic insulin signaling and glycemic control. Hepatic insulin resistance in diabetes is likely in part due to impaired pulsatile insulin secretion.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/14q2d0ccTest

المؤلفون: Adams, Jon D, Egan, Aoife M, Laurenti, Marcello C, Schembri Wismayer, Daniel, Bailey, Kent R, Cobelli, Claudio, Dalla Man, Chiara, Vella, Adrian

المساهمون: Adams, Jon D, Egan, Aoife M, Laurenti, Marcello C, Schembri Wismayer, Daniel, Bailey, Kent R, Cobelli, Claudio, Dalla Man, Chiara, Vella, Adrian

مصطلحات موضوعية: TCF7L2, endogenous glucose production, metabolism, α cell function, β cell function, Blood Glucose, Glucose, Human, Insulin, Postprandial Period, Diabetes Mellitus, Type 2, Glucagon, Transcription Factor 7-Like 2 Protein

الوصف: Background: The rs7903146 variant in the TCF7L2 gene is associated with defects in postprandial insulin and glucagon secretion and increased risk of type 2 diabetes. However, it is unclear if this variant has effects on glucose metabolism that are independent of islet function. Methods: We studied 54 nondiabetic subjects on two occasions where endogenous hormone secretion was inhibited by somatostatin. Twenty-nine subjects were homozygous for the diabetes-associated allele (TT) and 25 for the diabetes-protective allele (CC) at rs7903146, but otherwise matched for anthropometric characteristics. On 1 day, glucagon infused at a rate of 0.65 ng/kg/min, and at 0 min prevented a fall in glucagon (nonsuppressed day). On the contrary, infusion commenced at 120 min to create a transient fall in glucagon (suppressed day). Subjects received glucose (labeled with [3-3H]-glucose) infused to mimic the systemic appearance of oral glucose. Insulin was infused to mimic a prandial insulin response. Endogenous glucose production (EGP) was measured using the tracer dilution technique. Results: Lack of glucagon suppression increased postchallenge glucose concentrations and impaired EGP suppression. However, in the presence of matched insulin and glucagon concentrations, genetic variation in TCF7L2 did not alter glucose metabolism. Conclusion: These data suggest that genetic variation in TCF7L2 alters glucose metabolism through changes in islet hormone secretion.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35442800; info:eu-repo/semantics/altIdentifier/wos/WOS:000791311600001; volume:20; issue:6; firstpage:329; lastpage:335; numberofpages:7; journal:METABOLIC SYNDROME AND RELATED DISORDERS; http://hdl.handle.net/11577/3456004Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85136341434

الإتاحة: https://doi.org/10.1089/met.2021.0136Test
http://hdl.handle.net/11577/3456004Test

المؤلفون: Luijf, Yoeri M, DeVries, J Hans, Zwinderman, Koos, Leelarathna, Lalantha, Nodale, Marianna, Caldwell, Karen, Kumareswaran, Kavita, Elleri, Daniela, Allen, Janet M, Wilinska, Malgorzata E, Evans, Mark L, Hovorka, Roman, Doll, Werner, Ellmerer, Martin, Mader, Julia K, Renard, Eric, Place, Jerome, Farret, Anne, Cobelli, Claudio, Del Favero, Simone, Dalla Man, Chiara, Avogaro, Angelo, Bruttomesso, Daniela, Filippi, Alessio, Scotton, Rachele, Magni, Lalo, Lanzola, Giordano, Di Palma, Federico, Soru, Paola, Toffanin, Chiara, De Nicolao, Giuseppe, Arnolds, Sabine, Benesch, Carsten, Heinemann, Lutz, AP@home Consortium

مصطلحات موضوعية: Administration, Cutaneous, Adult, Algorithms, Blood Glucose, Blood Glucose Self-Monitoring, Cross-Over Studies, Diabetes Mellitus, Type 1, Equipment Design, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Infusion Pumps, Insulin, Insulin Infusion Systems, Male, Self Care, Treatment Outcome

الوصف: OBJECTIVE: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS: This study was a multicenter, randomized, three-way crossover, open-label trial in 48 patients with type 1 diabetes mellitus for at least 6 months, treated with continuous subcutaneous insulin infusion. Blood glucose was controlled for 23 h by the algorithm of the Universities of Pavia and Padova with a Safety Supervision Module developed at the Universities of Virginia and California at Santa Barbara (international artificial pancreas [iAP]), by the algorithm of University of Cambridge (CAM), or by patients themselves in open loop (OL) during three hospital admissions including meals and exercise. The main analysis was on an intention-to-treat basis. Main outcome measures included time spent in target (glucose levels between 3.9 and 8.0 mmol/L or between 3.9 and 10.0 mmol/L after meals). RESULTS: Time spent in the target range was similar in CL and OL: 62.6% for OL, 59.2% for iAP, and 58.3% for CAM. While mean glucose level was significantly lower in OL (7.19, 8.15, and 8.26 mmol/L, respectively) (overall P = 0.001), percentage of time spent in hypoglycemia (<3.9 mmol/L) was almost threefold reduced during CL (6.4%, 2.1%, and 2.0%) (overall P = 0.001) with less time ≤2.8 mmol/L (overall P = 0.038). There were no significant differences in outcomes between algorithms. CONCLUSIONS: Both CAM and iAP algorithms provide safe glycemic control.

وصف الملف: Print-Electronic; application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/302219Test

الإتاحة: https://doi.org/10.17863/CAM.49293Test
https://www.repository.cam.ac.uk/handle/1810/302219Test

المؤلفون: DALLA MAN, CHIARA, MICHELETTO, FRANCESCO, COBELLI, CLAUDIO, Sathananthan, Matheni, Vella, Adrian

المساهمون: DALLA MAN, Chiara, Micheletto, Francesco, Sathananthan, Matheni, Vella, Adrian, Cobelli, Claudio

مصطلحات موضوعية: Blood Glucose, C-Peptide, Eating, Glucagon-Like Peptide 1, Glucose Clamp Technique, Glucose Intolerance, Healthy Volunteer, Human, Insulin, Insulin-Secreting Cell, Linear Model, Meal, Middle Aged, Endocrinology, Diabetes and Metabolism, Medical Laboratory Technology

الوصف: Background: Glucagon-like peptide-1 (GLP-1) is a powerful insulin secretagogue that is secreted in response to meal ingestion. The ability to quantify the effect of GLP-1 on insulin secretion could provide insights into the pathogenesis and treatment of diabetes. We used a modification of a model of GLP-1 action on insulin secretion using data from a hyperglycemic clamp with concomitant GLP-1 infusion. We tested this model using data from a mixed meal test (MMT), thereby measuring GLP-1-induced potentiation of insulin secretion in response to a meal. Materials and Methods: The GLP-1 model is based on the oral C-peptide minimal model and assumes that over-basal insulin secretion depends linearly on GLP-1 concentration through the parameter , representing the -cell sensitivity to GLP-1. The model was tested on 62 subjects across the spectrum of glucose tolerance (age, 531 years; body mass index, 29.70.6kg/m(2)) studied with an MMT and provided a precise estimate of both -cell responsivity and indices. By combining with a measure of L-cell responsivity to glucose, one obtains a potentiation index (PI) (i.e., a measure of the L-cell's function in relation to prevailing -cell sensitivity to GLP-1). Results: Model-based measurement of GLP-1-induced insulin secretion demonstrates that the PI is significantly reduced in people with impaired glucose tolerance, compared with those with normal glucose tolerance. Conclusions: We describe a model that can quantitate the GLP-1-based contribution to insulin secretion in response to meal ingestion. This methodology will allow a better understanding of -cell function at various stages of glucose tolerance.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26756104; info:eu-repo/semantics/altIdentifier/wos/WOS:000368014600008; volume:18; issue:1; firstpage:39; lastpage:46; numberofpages:8; journal:DIABETES TECHNOLOGY & THERAPEUTICS; http://hdl.handle.net/11577/3229367Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84954429527; www.liebertonline.com/dia

الإتاحة: https://doi.org/10.1089/dia.2015.0146Test
http://hdl.handle.net/11577/3229367Test

المؤلفون: Zheng, Chao, Dalla Man, Chiara, Cobelli, Claudio, Groop, Leif, Zhao, Hongyu, Bale, Allen E, Shaw, Melissa, Duran, Elvira, Pierpont, Bridget, Caprio, Sonia, Santoro, Nicola

المصدر: Obesity (Silver Spring, Md.)

مصطلحات موضوعية: Blood Glucose, Male, Pediatric Obesity, Adolescent, Receptor, Melatonin, MT2, MTNR1B, IFG, Fasting, Hispanic or Latino, Polymorphism, Single Nucleotide, Article, White People, Black or African American, Prediabetic State, Diabetes Mellitus, Type 1, Insulin Secretion, G6PC2, Humans, Insulin, Female, fasting glucose, Child, childhood obesity, Adaptor Proteins, Signal Transducing

الوصف: Objective To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Design and Methods 346 Caucasians, 218 African Americans and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274 subjects underwent a second OGTT after 3.0±2.1 years. Results The MTNR1B rs10830963 variant was associated with higher fasting glucose levels and lower dynamic beta cell response in Caucasians and Hispanics (p0.10). Conclusions We show for the first time in obese youth that the MTNR1B variant is associated with an increased risk of IFG.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::0fb263d3b9387b7309fed631f4411dc6Test
http://europepmc.org/articles/PMC4414047Test

المؤلفون: VISENTIN, ROBERTO, DALLA MAN, CHIARA, COBELLI, CLAUDIO, Kudva, Yogish C., Basu, Ananda

المساهمون: Visentin, Roberto, DALLA MAN, Chiara, Kudva, Yogish C., Basu, Ananda, Cobelli, Claudio

مصطلحات موضوعية: Adolescent, Adult, Analysis of Variance, Area Under Curve, Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 1, Female, Human, Insulin Resistance, Male, Meal, Middle Aged, Reproducibility of Result, United State, United States Food and Drug Administration, Young Adult, Computer Simulation, Pancreas, Artificial, Endocrinology, Diabetes and Metabolism, Medical Laboratory Technology

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25531427; info:eu-repo/semantics/altIdentifier/wos/WOS:000347538900001; volume:17; issue:1; firstpage:1; lastpage:7; numberofpages:7; journal:DIABETES TECHNOLOGY & THERAPEUTICS; http://hdl.handle.net/11577/3167755Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84920842830; www.liebertonline.com/dia

الإتاحة: https://doi.org/10.1089/dia.2014.0192Test
http://hdl.handle.net/11577/3167755Test

المؤلفون: DALLA MAN, CHIARA, PILLONETTO, GIANLUIGI, RIZ, MICHELA, COBELLI, CLAUDIO

المساهمون: DALLA MAN, Chiara, Pillonetto, Gianluigi, Riz, Michela, Cobelli, Claudio

مصطلحات موضوعية: Intraclass correlation coefficient, Minimal model, Parameter estimation, Pearson correlation coefficient, Adult, Blood Glucose, C-Peptide, Female, Glucose Tolerance Test, Human, Insulin, Insulin-Secreting Cell, Male, Meal, Middle Aged, Reproducibility of Result, Insulin Resistance, Models, Biological, Uncertainty, Physiology, Physiology (medical), Endocrinology, Diabetes and Metabolism

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25852005; info:eu-repo/semantics/altIdentifier/wos/WOS:000356256100005; volume:308; issue:11; firstpage:E971; lastpage:E977; numberofpages:7; journal:AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11577/3167749Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930833063; http://ajpendo.physiology.org/content/ajpendo/308/11/E971.full.pdfTest

الإتاحة: https://doi.org/10.1152/ajpendo.00350.2014Test
http://hdl.handle.net/11577/3167749Test
http://ajpendo.physiology.org/content/ajpendo/308/11/E971.full.pdfTest

المؤلفون: Javed, Asma, Vella, Adrian, Balagopal, P. Babu, Fischer, Philip R, Weaver, Amy L, PICCININI, FRANCESCA, DALLA MAN, CHIARA, COBELLI, CLAUDIO, Giesler, Paula D, Laugen, Jeanette M, Kumar, Seema

المساهمون: Javed, Asma, Vella, Adrian, Balagopal, P. Babu, Fischer, Philip R, Weaver, Amy L, Piccinini, Francesca, DALLA MAN, Chiara, Cobelli, Claudio, Giesler, Paula D, Laugen, Jeanette M, Kumar, Seema

مصطلحات موضوعية: disposition index, insulin action, insulin secretion, obese adolescent, vitamin D supplementation, Adolescent, Blood Glucose, Body Mass Index, Child, Cholecalciferol, Double-Blind Method, Female, Follow-Up Studie, Healthy Volunteer, Human, Insulin, Insulin Resistance, Insulin-Secreting Cell, Male, Obesity, Prospective Studie, Treatment Outcome, Vitamin, Dietary Supplements

الوصف: There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25644349; info:eu-repo/semantics/altIdentifier/wos/WOS:000349057200014; volume:145; issue:2; firstpage:284; lastpage:290; numberofpages:7; journal:JOURNAL OF NUTRITION; http://hdl.handle.net/11577/3167753Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84964262316

الإتاحة: https://doi.org/10.3945/jn.114.202010Test
http://hdl.handle.net/11577/3167753Test

المؤلفون: Mallad, Ashwini, Hinshaw, Ling, Dadlani, Vikash, Basu, Rita, Lingineni, Ravi, Johnson, Matthew L., Carter, Rickey, Kudva, Yogish C., Basu, Ananda, SCHIAVON, MICHELE, DALLA MAN, CHIARA, COBELLI, CLAUDIO

المساهمون: Mallad, Ashwini, Hinshaw, Ling, Schiavon, Michele, DALLA MAN, Chiara, Dadlani, Vikash, Basu, Rita, Lingineni, Ravi, Cobelli, Claudio, Johnson, Matthew L., Carter, Rickey, Kudva, Yogish C., Basu, Ananda

مصطلحات موضوعية: Exercise, Insulin mobilization, Postprandial glucose kinetic, Adolescent, Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 1, Exercise Test, Female, Gastric Emptying, Human, Insulin, Insulin Infusion System, Male, Middle Aged, Young Adult, Postprandial Period, Physiology, Physiology (medical), Endocrinology, Diabetes and Metabolism

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25898950; info:eu-repo/semantics/altIdentifier/wos/WOS:000356259500007; volume:308; issue:12; firstpage:E1106; lastpage:E1115; numberofpages:10; journal:AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11577/3167748Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84931039420; http://ajpendo.physiology.org/content/ajpendo/308/12/E1106.full.pdfTest

الإتاحة: https://doi.org/10.1152/ajpendo.00014.2015Test
http://hdl.handle.net/11577/3167748Test
http://ajpendo.physiology.org/content/ajpendo/308/12/E1106.full.pdfTest