المؤلفون: Itani, Mohamed A., Schiller, Ulf D., Schmieschek, Sebastian, Hetherington, James, Bernabeu, Miguel O., Chandrashekar, Hoskote, Robertson, Fergus, Coveney, Peter V., Groen, Derek

المصدر: Journal of Computational Science; Jul2015, Vol. 9, p150-155, 6p

مصطلحات موضوعية: CEREBROVASCULAR disease, BRAIN blood-vessels, ORGAN rupture, PRIMARY care, SIMULATION methods & models

مستخلص: Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm formation and rupture. The precise relation is however still an open field of investigation. We present an automated ensemble simulation method for modelling cerebrovascular blood flow under a range of flow regimes. By automatically constructing and performing an ensemble of multiscale simulations, where we unidirectionally couple a 1D solver with a 3D lattice-Boltzmann code, we are able to model the blood flow in a patient artery over a range of flow regimes. We apply the method to a model of a middle cerebral artery, and find that this approach helps us to fine-tune our modelling techniques, and opens up new ways to investigate cerebrovascular flow properties. [ABSTRACT FROM AUTHOR]

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المؤلفون: Itani, Mohamed A., Schiller, Ulf D., Schmieschek, Sebastian, Hetherington, James, Bernabeu, Miguel O., Chandrashekar, Hoskote, Robertson, Fergus, Coveney, Peter V., Groen, Derek

المصدر: Itani, M A, Schiller, U D, Schmieschek, S, Hetherington, J, Bernabeu, M O, Chandrashekar, H, Robertson, F, Coveney, P V & Groen, D 2015, ' An automated multiscale ensemble simulation approach for vascular blood flow ', Journal of Computational Science, vol. 9, pp. 150-155 . https://doi.org/10.1016/j.jocs.2015.04.008Test

مصطلحات موضوعية: Computational Engineering, Finance, and Science (cs.CE), FOS: Computer and information sciences, Multiscale modelling, Computer Science - Distributed, Parallel, and Cluster Computing, Modelling and Simulation, Parallel programming, Distributed, Parallel, and Cluster Computing (cs.DC), Blood flow, Ensemble simulation, Computer Science - Computational Engineering, Finance, and Science, High-performance computing, Theoretical Computer Science, Computer Science(all)

الوصف: Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm formation and rupture. The precise relation is however still an open field of investigation. We present an automated ensemble simulation method for modelling cerebrovascular blood flow under a range of flow regimes. By automatically constructing and performing an ensemble of multiscale simulations, where we unidirectionally couple a 1D solver with a 3D lattice-Boltzmann code, we are able to model the blood flow in a patient artery over a range of flow regimes. We apply the method to a model of a middle cerebral artery, and find that this approach helps us to fine-tune our modelling techniques, and opens up new ways to investigate cerebrovascular flow properties.
Journal of Computational Science (in press), 10 pages, 6 figures, 2 tables

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe9b1bf180405693249f6aa58e6fe1dTest