التفاصيل البيبلوغرافية
| العنوان: |
Progression of myeloproliferative neoplasm with BCR::JAK2 fusion to acute leukemia of ambiguous lineage. |
| المؤلفون: |
Suárez, Edwin Uriel, Piris, Miguel Ángel, Rodríguez-Pinilla, Socorro María, García, Juan F., López-Lorenzo, José Luis, Cornago-Navascués, Javier, Salgado-Sánchez, Rocío, Castaño-Bonilla, Tamara, Mata-Serna, Raquel, Alonso-Domínguez, Juan M., Llamas, Pilar |
| المصدر: |
Annals of Hematology; May2024, Vol. 103 Issue 5, p1797-1799, 3p |
| مصطلحات موضوعية: |
MYELOPROLIFERATIVE neoplasms, ACUTE leukemia, MYELOFIBROSIS, MAST cell disease, EXTRAMEDULLARY diseases, BLOOD diseases, BLOOD cell count |
| مستخلص: |
This letter, published in the Annals of Hematology, describes the case of a 58-year-old man who was initially diagnosed with myeloproliferative neoplasm (MPN) with a BCR::JAK2 fusion. The patient was treated with ruxolitinib, but later developed acute leukemia of ambiguous lineage (ALAL). Despite treatment with intensive chemotherapy, the patient's condition worsened, and they ultimately underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, the patient passed away due to complications. The letter highlights the rarity of the BCR::JAK2 fusion in MPN and the challenges in managing ALAL. The authors emphasize the need for further research and improved treatment options for post-MPN acute leukemia. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
