التفاصيل البيبلوغرافية
| العنوان: |
Carbapenem-resistant Pseudomonas aeruginosa producing NDM-1. |
| العنوان البديل: |
Pseudomonas aeruginosa resistente aos carbapenêmicos produtor de NDM-1. (Portuguese) |
| المؤلفون: |
Freitag Jorge, Paulo Ricardo, Paulo Pimenta, João, Silveira de Brito, Cristiane, Marques Ribas, Rosineide, Gontijo Filho, Paulo Pinto, de Almeida e Borges, Lizandra Ferreira |
| المصدر: |
Minas Gerais Medical Journal / Revista Médica de Minas Gerais; 2023, Vol. 33, p1-5, 5p |
| مصطلحات موضوعية: |
CARBAPENEMS, BLOOD, BACTERIAL proteins, MICROBIAL sensitivity tests, POLYMERASE chain reaction, MULTIDRUG resistance, DESCRIPTIVE statistics, URINE, PSEUDOMONAS diseases, GENE expression, CELL culture, BETA lactamases, DEVELOPING countries, PSEUDOMONAS, GENOTYPES, PHENOTYPES, GRAM-negative bacteria, MOLECULAR pathology |
| مصطلحات جغرافية: |
BRAZIL |
| الملخص (بالإنجليزية): |
Introduction: NDM-1-producing is increasingly common in new generation of multidrug-resistant bacteria. Objective and Methods: This study reports the occurrence of metallo-ß-lactamase, especially NDM in Pseudomonas aeruginosa in the state of Minas Gerais, Brazil. A disc combination test used to screen isolates and Polymerase Chain Reaction was used to search for metallo-ß-lactamases genes. Results: Among the 95 strains analyzed, all were resistant to carbapenems, 20% were phenotypically positive for metallo-ß-lactamases, and 1% were positive for blaSPM gene and 2.1% for blaNDM. Conclusions: In Brazil, SPM carbapenemases always was predominant among P. aeruginosa clinical isolates, but not NDM. This study highlights the need to review clinical protocols, in order to contain the dissemination of this profile. [ABSTRACT FROM AUTHOR] |
| Abstract (Portuguese): |
Introdução: A produção de NDM-1 é cada vez mais comum nesta nova geração de bactérias multirresistentes. Objetivo e Métodos: Este estudo avalia a ocorrência de metalo-ß-lactamase, especialmente NDM em Pseudomonas aeruginosa no estado de Minas Gerais, Brasil, por meio de um teste do disco combinado para triagem de isolados e Reação em Cadeia de Polimerase para pesquisar os genes para metalo-ß-lactamases. Resultados: Das 95 cepas analisadas, todas resistentes aos carbapenêmicos, 20% eram fenotipicamente positivas para metalo-ß-lactamases, e 1% positivas para o gene blaSPM e 2,1% para blaNDM. Conclusões: No Brasil, as carbapenemases SPM sempre foram predominantes entre os isolados clínicos de P. aeruginosa, mas não a NDM. Este estudo destaca a necessidade de revisão de protocolos clínicos, a fim de conter a disseminação desse novo perfil. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
