دورية أكاديمية
Evaluation of Anti-Activated Factor X Activity and Activated Partial Thromboplastin Time Relations and Their Association with Bleeding and Thrombosis during Veno-Arterial ECMO Support: A Retrospective Study
| العنوان: | Evaluation of Anti-Activated Factor X Activity and Activated Partial Thromboplastin Time Relations and Their Association with Bleeding and Thrombosis during Veno-Arterial ECMO Support: A Retrospective Study |
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| المؤلفون: | Moussa, Mouhamed Djahoum, Soquet, Jérôme, Lamer, Antoine, Labreuche, Julien, Gantois, Guillaume, Dupont, Annabelle, Abou-Arab, Osama, Rousse, Natacha, Liu, Vincent, Brandt, Caroline, Foulon, Valentin, Leroy, Guillaume, Schurtz, Guillaume, Jeanpierre, Emmanuel, Duhamel, Alain, Susen, Sophie, Vincentelli, André, Robin, Emmanuel |
| المساهمون: | Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), CHU Amiens-Picardie, Institut Coeur Poumon CHU Lille, Department of Physics Berkeley, University of California Berkeley (UC Berkeley), University of California (UC)-University of California (UC), École Nationale d'Ingénieurs de Brest (ENIB), Equipe Observations Signal & Environnement (Lab-STICC_OSE), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom Paris (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom Paris (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom Paris (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom Paris (IMT), Pôle Santé Publique, Pharmacie et Pharmacologie |
| المصدر: | ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.science/hal-04370230Test ; Journal of Clinical Medicine, 2021, 10 (10), pp.2158. ⟨10.3390/jcm10102158⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université de Bretagne Occidentale: HAL |
| مصطلحات موضوعية: | extracorporeal membrane oxygenation activated partial thromboplastin time anti-factor Xa intravenous unfractionated heparin monitoring thrombotic complications bleeding, extracorporeal membrane oxygenation, activated partial thromboplastin time, anti-factor Xa, intravenous unfractionated heparin monitoring, thrombotic complications, bleeding, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background: We aimed to investigate the relationship between anti-activated Factor X (anti-FXa) and activated Partial Thromboplastin Time (aPTT), and its modulation by other haemostasis co-variables during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. We further investigated their association with serious bleeding and thrombotic complications. Methods: This retrospective single-center study included 265 adults supported by VA-ECMO for refractory cardiogenic shock from January 2015 to June 2019. The concordance of anti-FXa and aPTT and their correlations were assessed in 1699 paired samples. Their independent associations with serious bleeding or thrombotic complications were also analysed in multivariate analysis. Results: The concordance rate of aPTT with anti-FXa values was 50.7%, with 39.3% subtherapeutic aPTT values. However, anti-FXa and aPTT remained associated (β = 0.43 (95% CI 0.4–0.45) 10−2 IU/mL, p < 0.001), with a significant modulation by several biological co-variables. There was no association between anti-FXa nor aPTT values with serious bleeding or with thrombotic complications. Conclusion: During VA-ECMO, although anti-FXa and aPTT were significantly associated, their values were highly discordant with marked sub-therapeutic aPTT values. These results should favour the use of anti-FXa. The effect of biological co-variables and the failure of anti-FXa and aPTT to predict bleeding and thrombotic complications underline the complexity of VA-ECMO-related coagulopathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04370230; https://hal.science/hal-04370230Test; https://hal.science/hal-04370230/documentTest; https://hal.science/hal-04370230/file/jcm-10-02158-v2.pdfTest |
| DOI: | 10.3390/jcm10102158 |
| الإتاحة: | https://doi.org/10.3390/jcm10102158Test https://hal.science/hal-04370230Test https://hal.science/hal-04370230/documentTest https://hal.science/hal-04370230/file/jcm-10-02158-v2.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D0C818AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcm10102158 |
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