التفاصيل البيبلوغرافية
| العنوان: |
Vitamin D Levels in Black Americans and the Association With Left Ventricular Remodeling and Incident Heart Failure With Preserved Ejectin Fraction: The Jackson Heart Study. |
| المؤلفون: |
Kamimura, DAISUKE, YIMER, WONDWOSEN K., SHAH, AMIL M., MENTZ, ROBERT J., OSHUNBADE, ADEBAMIKE, HAMID, ARSALAN, SUZUKI, TAKEKI, CLARK III, DONALD, WALLER, JAMARIUS, FOX, ERVIN R., CORREA, ADOLFO, BUTLER, JAVED, HALL, MICHAEL E. |
| المصدر: |
Journal of Cardiac Failure; Feb2023, Vol. 29 Issue 2, p150-157, 8p |
| مستخلص: |
• A lower serum vitamin D 3 concentration has been associated with an increased risk of cardiovascular disease. However, the associations between serum vitamin D 3 levels and heart failure with preserved ejection fraction (HFpEF) have not been well-characterized. • Lower serum vitamin D 3 levels were associated with left ventricular concentric remodeling and incident HF, mainly HFpEF in Black Americans. • Further investigation is required to examine whether supplementation of vitamin D 3 can prevent left ventricular concentric remodeling and incident HFpEF in Black Americans. In observational studies, a lower serum vitamin D 3 concentration has been associated with an increased risk of cardiovascular disease. However, the associations between serum vitamin D 3 levels and left ventricular (LV) structure and heart failure with preserved ejection fraction (HFpEF) have not been well-characterized among Black Americans. The prevalence of vitamin D 3 deficiency is higher among Black Americans than in other race/ethnicity groups. We hypothesized that serum vitamin D 3 levels are associated with LV concentric remodeling and incident HFpEF in Black Americans. Among 5306 Black Americans in the Jackson Heart Study cohort, we investigated the relationships between serum vitamin D 3 levels and LV structure and function, evaluated with echocardiography, and incident HF hospitalization, categorized as either HF with reduced EF (HFrEF; an EF of <50%) or HFpEF (an EF of ≥50%). After adjustment for possible confounding factors, lower vitamin D 3 levels were associated with greater relative wall thickness (β for 1 standard deviation [SD] increase –0.003, 95% confidence interval –0.005 to –0.000). Over a median follow-up period of 11 years (range 10.2–11.0 years), 340 participants developed incident HF (7.88 cases per 1000 person-years), including 146 (43%) HFrEF and 194 (57%) HFpEF cases. After adjustment, higher serum vitamin D 3 levels were associated with decreased hazard for HF overall (hazard ratio for 1 SD increase 0.88, 95% confidence interval 0.78–0.99) driven by a significant association with HFpEF (hazard ratio for 1 SD increase 0.84, 95% confidence interval 0.71–0.99). In this community-based Black American cohort, lower serum vitamin D 3 levels were associated with LV concentric remodeling and an increased hazard for HF, mainly HFpEF. Further investigation is required to examine whether supplementation with vitamin D 3 can prevent LV concentric remodeling and incident HFpEF in Black Americans. [Display omitted] [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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