دورية أكاديمية
Biotechnological applications of occlusion bodies of Baculoviruses
| العنوان: | Biotechnological applications of occlusion bodies of Baculoviruses |
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| المؤلفون: | Lopez, Maria Gabriela, Diez, Michay, Alfonso, Victoria, Taboga, Oscar Alberto |
| المصدر: | Applied microbiology and biotechnology 102 (16) : 6765–6774. (August 2018) |
| بيانات النشر: | Springer |
| سنة النشر: | 2018 |
| المجموعة: | Inta Digital (ID - Instituto Nacional de Tecnología Agropecuaria) |
| مصطلحات موضوعية: | Baculovirus, Proteínas Recombinantes, Biotecnología, Recombinant Proteins, Biotechnology, Occlusion Bodies, BEVS, Polyhedrin, Cuerpos de Oclusión, Polihedrina |
| الوصف: | The ability of Baculoviruses to hyper-express very late genes as polyhedrin, the major component of occlusion bodies (OBs) or polyhedra, has allowed the evolution of a system of great utility for biotechnology. The main function of polyhedra in nature is to protect Baculovirus in the environment. The possibility of incorporating foreign proteins into the crystal by fusing them to polyhedrin (POLH) opened novel potential biotechnological uses. In this review, we summarize different applications of Baculovirus chimeric OBs. Basically, the improvement of protein expression and purification with POLH as a fusion partner; the use of recombinant polyhedra as immunogens and antigens, and the incorporation of proteins into polyhedra to improve Baculoviruses as bioinsecticides. The results obtained in each area and the future trends in these topics are also discussed. ; Instituto de Biotecnología ; Fil: Lopez, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Diez, Michay. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Alfonso, Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0175-7598 |
| العلاقة: | http://hdl.handle.net/20.500.12123/4456Test; 1432-0614 (Online); https://doi.org/10.1007/s00253-018-9130-2Test |
| DOI: | 10.1007/s00253-018-9130-2 |
| الإتاحة: | https://doi.org/20.500.12123/4456Test https://doi.org/10.1007/s00253-018-9130-2Test https://hdl.handle.net/20.500.12123/4456Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.DE95CFEA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01757598 |
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| DOI: | 10.1007/s00253-018-9130-2 |