Modularly Assembled Magnetite Nanoparticles Enhance in Vivo Targeting for Magnetic Resonance Cancer Imaging
| العنوان: | Modularly Assembled Magnetite Nanoparticles Enhance in Vivo Targeting for Magnetic Resonance Cancer Imaging |
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| المؤلفون: | Jyh-Horng Chen, Yonhua Tzeng, Jih Ru Hwu, Jun-Cheng Weng, Ping Ching Wu, Fong Yu Cheng, Tsung Lin Tsai, Chen-Sheng Yeh, Dar-Bin Shieh, Chia Hao Su, Wu Chou Su |
| المصدر: | Bioconjugate Chemistry. 19:1972-1979 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Nitrilotriacetic Acid, Biodistribution, Cell Survival, Kinetics, Biomedical Engineering, Pharmaceutical Science, Nanoparticle, Bioengineering, Nanotechnology, Peptides, Cyclic, Absorption, Mice, Molecular recognition, Nickel, In vivo, Cell Line, Tumor, Cricetinae, Materials Testing, medicine, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Pharmacology, Chemistry, Organic Chemistry, Cancer, medicine.disease, Magnetic Resonance Imaging, Ferrosoferric Oxide, Case-Control Studies, Cancer cell, Biophysics, Nanoparticles, Mouth Neoplasms, Molecular imaging, Oligopeptides, Biotechnology |
| الوصف: | Modularly assembled targeting nanoparticles were synthesized through self-assembly of targeting moieties on surfaces of functional nanoparticles. Specific molecular recognition of nickel nitrilotriacetate on Fe3O4 nanoparticles with hexahistidine tag on RGD4C peptides results in precisely controlled orientation of the targeting peptides. Better selectivity of the self-assembled RGD4C-Fe3O4 nanoparticles targeting oral cancer cells than that achievable through a conventional chemical cross-link strategy was demonstrated by means of atomic absorption spectrometry (AAS). An oral cancer hamster model was applied to reveal specific in vivo targeting and MR molecular imaging contrast in cancer lesions expressing alphavbeta3 integrin. Both AAS and MRI revealed that the self-assembled nanoparticles improved the targeting efficiency and reduced the hepatic uptake as compared with the conventional chemical cross-link particles. We investigated the biosafety, biodistribution, and kinetics of the nanoparticles and found that the nanoparticles were significantly cleared from the liver and kidneys after one week. By recombining the desired targeting moiety and various functional nanoparticles through self-assembly, this new modularly designed platform has the capability of enhancing the efficiency of targeted diagnosis and therapies for a wide spectrum of biomedical applications. |
| تدمد: | 1520-4812 1043-1802 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a09afab2784f256444c18bdcbdbec7fTest https://doi.org/10.1021/bc800092wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a09afab2784f256444c18bdcbdbec7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15204812 10431802 |
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