التفاصيل البيبلوغرافية
| العنوان: |
Estimation and Comparison of HIV-Specific Substitution Matrices |
| المؤلفون: |
Kee, Jia Jin |
| المساهمون: |
Edlefsen, Paul |
| سنة النشر: |
2014 |
| المجموعة: |
University of Washington, Seattle: ResearchWorks |
| مصطلحات موضوعية: |
Biostatistics, Bioinformatics |
| الوصف: |
Thesis (Master's)--University of Washington, 2014 ; Amino acid substitution matrices are commonly used for sequence alignment, phylogenetic inference and sequence comparison. Empirical organism-specific substitution matrices constructed using only sequence data from a particular organism are thought to lead to more accurate analyses. In HIV research, the standard substitution matrices are the between- and within-host matrices estimated using HIV sequences introduced by Nickle et al. (2007). This thesis focuses on constructing more granular HIV-specific matrices (clade-specific matrices and gene-specific matrices) and comparing the matrices in a way that accounts for error in matrix estimation. Using standard errors of parameter estimates predicted from a two-part linear model, the analyses indicate statistically significant difference between HIV clade B and HIV clade C matrices as well as between HIV Env gene and HIV Gag gene matrices upon performing Bonferroni-corrected comparisons of 189 estimates of amino acid exchangeability parameters. |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Kee_washington_0250O_13682.pdf; http://hdl.handle.net/1773/26004Test |
| الإتاحة: |
http://hdl.handle.net/1773/26004Test |
| حقوق: |
Copyright is held by the individual authors. |
| رقم الانضمام: |
edsbas.FD5D8EED |
| قاعدة البيانات: |
BASE |
