Long‐term renal injury in ANCA‐associated vasculitis: an analysis of 31 patients with follow‐up biopsies
| العنوان: | Long‐term renal injury in ANCA‐associated vasculitis: an analysis of 31 patients with follow‐up biopsies |
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| المؤلفون: | Herbert A. Hauer, Fokko J. van der Woude, Cornelis A. Verburgh, Renato Alberto Sinico, Laure-Hélène Noël, Hans C. van Houwelingen, Ingeborg M. Bajema, Emile de Heer, Rüdiger Waldherr, Jan A. Bruijn, Gill Gaskin, Franco Ferrario, Philippe Lesavre, E. Christiaan Hagen |
| المساهمون: | Hauer, H, Bajema, I, Hagen, E, Noël, L, Ferrario, F, Waldherr, R, van Houwelingen, H, Lesavre, P, Sinico, R, van der Woude, F, Gaskin, G, Verburgh, C, de Heer, E, Bruijn, J |
| المصدر: | Nephrology Dialysis Transplantation. 17:587-596 |
| بيانات النشر: | Oxford University Press (OUP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, Vasculitis, Pathology, medicine.medical_specialty, Biopsy, Kidney, urologic and male genital diseases, Follow-Up Studie, Antibodies, Antineutrophil Cytoplasmic, Necrosis, chemistry.chemical_compound, Retrospective Studie, medicine, Humans, Aged, Retrospective Studies, Anti-neutrophil cytoplasmic antibody, Transplantation, Creatinine, medicine.diagnostic_test, urogenital system, business.industry, Glomerulosclerosis, Middle Aged, Necrosi, medicine.disease, medicine.anatomical_structure, chemistry, Nephrology, Female, Renal biopsy, business, Cell Division, Human, Follow-Up Studies, Kidney disease |
| الوصف: | Background. We reported previously that in renal disease in relation to antineutrophil cytoplasm auto-antibodies (ANCA)-associated vasculitis, renal outcome correlates better with the percentage of normal glomeruli than with separate active lesions. This may imply that glomeruli, once affected by necrotizing and crescentic lesions, are irreversibly damaged. We quantified and evaluated the course of renal lesions in the present study. Methods. We retrospectively analysed 31 patients with renal disease in relation to ANCA-associated vasculitis, all treated with immunosuppressive drugs. In all patients, a renal biopsy was performed at diagnosis. A follow-up biopsy was performed in all patients on the indication of a suspected renal relapse, after a mean interval of 31 months. Results. The mean percentage of normal glomeruli in the renal biopsy did not change over time (29% in the initial and 30% in the follow-up biopsy). The mean percentage of glomeruli with crescents, however, significantly decreased from 57 to 30% (P < 0.001). The percentage of glomerulosclerosis significantly increased from 12 to 39% (P < 0.001). The data were independent of diagnosis, gender, age, time interval between the biopsies, and treatment. Conclusions. This is the first study to quantify glomerular changes between two time points in patients with renal vasculitis. Our results suggest that, on average, no new glomeruli are recruited into the active disease process. The sum of the percentage of crescentic and sclerotic glomeruli in the initial biopsies is larger than the percentage of sclerotic glomeruli in the follow-up biopsies. Thus, therapy seems not only to prevent normal glomeruli from being recruited into the active disease process for a certain time, but seems also to allow part of the active lesions to revert into a normal phenotype, although another part of the active lesions will be transformed to a chronic phenotype |
| وصف الملف: | STAMPA |
| تدمد: | 1460-2385 0931-0509 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32102672d0413acb058c2b524d7df86aTest https://doi.org/10.1093/ndt/17.4.587Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32102672d0413acb058c2b524d7df86a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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