دورية أكاديمية

The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.

التفاصيل البيبلوغرافية
العنوان: The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.
المؤلفون: Castro, E, Mikropoulos, C, Bancroft, EK, Dadaev, T, Goh, C, Taylor, N, Saunders, E, Borley, N, Keating, D, Page, EC, Saya, S, Hazell, S, Livni, N, deSouza, N, Neal, D, Hamdy, FC, Kumar, P, Antoniou, AC, Kote-Jarai, Z, PROFILE Study Steering Committee, Eeles, RA
المساهمون: Saunders, Edward, deSouza, Nandita, Kote-Jarai, Zsofia, Eeles, Rosalind
بيانات النشر: WILEY
سنة النشر: 2016
المجموعة: The Institute of Cancer Research (ICR): Publications Repository
مصطلحات موضوعية: PROFILE Study Steering Committee, Prostate, Humans, Prostatic Neoplasms, Prostate-Specific Antigen, Diffusion Magnetic Resonance Imaging, Biopsy, Cross-Sectional Studies, Feasibility Studies, Pilot Projects, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Male, Early Detection of Cancer
الوصف: BACKGROUND: A better assessment of individualized prostate cancer (PrCa) risk is needed to improve screening. The use of the prostate-specific antigen (PSA) level for screening in the general population has limitations and is not currently advocated. Approximately 100 common single nucleotide polymorphisms (SNPs) have been identified that are associated with the risk of developing PrCa. The PROFILE pilot study explored the feasibility of using SNP profiling in men with a family history (FH) of PrCa to investigate the probability of detecting PrCa at prostate biopsy (PB). The primary aim of this pilot study was to determine the safety and feasibility of PrCa screening using transrectal ultrasound-guided PB with or without diffusion-weighted magnetic resonance imaging (DW-MRI) in men with a FH. A secondary aim was to evaluate the potential use of SNP profiling as a screening tool in this population. PATIENTS AND METHODS: A total of 100 men aged 40-69 years with a FH of PrCa underwent PB, regardless of their baseline PSA level. Polygenic risk scores (PRSs) were calculated for each participant using 71 common PrCa susceptibility alleles. We treated the disease outcome at PB as the outcome variable and evaluated its associations with the PRS, PSA level, and DW-MRI findings using univariate logistic regression. RESULTS: Of the 100 men, 25 were diagnosed with PrCa, of whom 12 (48%) had clinically significant disease. Four adverse events occurred and no deaths. The PSA level and age at study entry were associated with PrCa at PB (p = .00037 and p = .00004, respectively). CONCLUSION: The results of the present pilot study have demonstrated that PB is a feasible and safe method of PrCa screening in men with a FH, with a high proportion of PrCa identified requiring radical treatment. It is feasible to collect data on PrCa-risk SNPs to evaluate their combined effect as a potential screening tool. A larger prospective study powered to detect statistical associations is in progress. IMPLICATIONS FOR PRACTICE: Prostate biopsy ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: Print-Electronic; 722; application/pdf
اللغة: English
تدمد: 1083-7159
1549-490X
العلاقة: The oncologist, 2016, 21 (6), pp. 716 - 722; https://repository.icr.ac.uk/handle/internal/231Test
DOI: 10.1634/theoncologist.2015-0336
الإتاحة: https://doi.org/10.1634/theoncologist.2015-0336Test
https://repository.icr.ac.uk/handle/internal/231Test
رقم الانضمام: edsbas.1EE1F2E6
قاعدة البيانات: BASE
الوصف
تدمد:10837159
1549490X
DOI:10.1634/theoncologist.2015-0336