المؤلفون: Michelle Tran, Rachel L. Signorelli, Adriana Yamaguchi, Eefie Chen, Michael Holinstat, Anthony T. Iavarone, Adam R. Offenbacher, Theodore Holman

مصطلحات موضوعية: Blood Platelets, Biochemistry & Molecular Biology, Biophysics, Deuterium Exchange Measurement, Single Nucleotide, Hematology, Deuterium, Arachidonate 12-Lipoxygenase, Biochemistry, Liposomes, Humans, 2.1 Biological and endogenous factors, Biochemistry and Cell Biology, Polymorphism, Aetiology, Molecular Biology, Hydrogen

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f9a998da61ed346989afd2958a0730Test
https://escholarship.org/uc/item/60g5005rTest

المؤلفون: Neel H. Shah, Christine L. Gee, John Kuriyan, Jean M. Badroos, Helen T. Hobbs, Susan Marqusee

المصدر: Protein Science : A Publication of the Protein Society

مصطلحات موضوعية: Protein Conformation, alpha-Helical, Conformational change, Full‐Length Papers, T-Lymphocytes, Genetic Vectors, Gene Expression, Syk, chemical and pharmacologic phenomena, Adaptive Immunity, Molecular Dynamics Simulation, Crystallography, X-Ray, SH2 domain, Biochemistry, Full‐Length Paper, evolution, Immunoreceptor tyrosine-based activation motif, Escherichia coli, Animals, Humans, Syk Kinase, Protein Interaction Domains and Motifs, Cloning, Molecular, Tyrosine, Molecular Biology, B-Lymphocytes, Binding Sites, ZAP-70 Protein-Tyrosine Kinase, Chemistry, conformational landscape, hydrogen–deuterium exchange mass spectrometry, tyrosine kinase signaling, Deuterium Exchange Measurement, hemic and immune systems, Biological Evolution, Recombinant Proteins, Protein kinase domain, protein dynamics, Biophysics, Phosphorylation, Protein Conformation, beta-Strand, Tyrosine kinase, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838256900e2374647a4621bc4fc68d20Test
https://doi.org/10.1002/pro.4199Test

المؤلفون: Tuomas P. J. Knowles, Georg Meisl, Don L. Rempel, Eva Illes-Toth, Michael L. Gross

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: Gene isoform, Physiology, Cognitive Neuroscience, Kinetics, Mutant, Peptide, Biochemistry, Article, 03 medical and health sciences, Residue (chemistry), 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, Humans, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Amyloid beta-Peptides, biology, Deuterium Exchange Measurement, Cell Biology, General Medicine, Deuterium, Peptide Fragments, In vitro, chemistry, Biophysics, biology.protein, Hydrogen–deuterium exchange, 030217 neurology & neurosurgery, Hydrogen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b75628e276ac4f16ab8c107ac0905a3Test
https://doi.org/10.1021/acschemneuro.1c00072Test

المؤلفون: Julie Ducharme, Vanja Polic, Christopher J. Thibodeaux, Karine Auclair

المصدر: ACS Chemical Biology. 16:882-890

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Allosteric regulation, Hydrogen Deuterium Exchange-Mass Spectrometry, Plasma protein binding, Molecular Dynamics Simulation, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Bioconjugation, 010405 organic chemistry, Ligand, Chemistry, Deuterium Exchange Measurement, General Medicine, Deuterium, Small molecule, 0104 chemical sciences, 3. Good health, 030104 developmental biology, Biophysics, Molecular Medicine, Hydrogen–deuterium exchange, Allosteric Site, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0676cc08793fae1577d21f2c72cee82Test
https://doi.org/10.1021/acschembio.1c00084Test

المؤلفون: Alice R Eddershaw, Karl Syson, Paul R. J. Davey, Gregory Hamm, Christopher D. Stubbs, Paul Clarkson, Elizabeth Underwood, Lucy V Edwardes

المصدر: Biochemistry. 59:4775-4786

مصطلحات موضوعية: Models, Molecular, Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, In Vitro Techniques, Biochemistry, Mass Spectrometry, Substrate Specificity, 03 medical and health sciences, Protein structure, Catalytic Domain, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Enzyme Inhibitors, Protein Structure, Quaternary, Ternary complex, Adaptor Proteins, Signal Transducing, 0303 health sciences, Chemistry, Protein arginine methyltransferase 5, 030302 biochemistry & molecular biology, Deuterium Exchange Measurement, Recombinant Proteins, Kinetics, Biophysics, Hydrogen–deuterium exchange, Steady state (chemistry)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c63875119c271f482688a035fe6bfcTest
https://doi.org/10.1021/acs.biochem.0c00554Test

المؤلفون: Cunle Wu, Yves Fortin, Andrea Acel, Marie Parat, Denis L'Abbé, Mélanie Duchesne, Shawn C. Chafe, Jason Baardsnes, Shoukat Dedhar, Mylene Gosselin, John F. Kelly, Anna Robotham, Joey G. Sheff, Anne E.G. Lenferink, Henk van Faassen, Traian Sulea, Félix Malenfant, Paul C. McDonald, Shannon Awrey, Jean Lefebvre, Alex Pelletier

المصدر: mAbs
article-version (VoR) Version of Record

مصطلحات موضوعية: tumor, medicine.drug_class, Immunology, Allosteric regulation, carbonic anhydrase, Hydrogen Deuterium Exchange-Mass Spectrometry, anti-cancer target, Monoclonal antibody, Epitope, antibody-drug conjugate, hydrogen-deuterium, spectrometry, 03 medical and health sciences, 0302 clinical medicine, Report, Catalytic Domain, antibody, medicine, Extracellular, Immunology and Allergy, tumor microenvironment, Humans, mapping, 030304 developmental biology, mass spectrometry, chemistry.chemical_classification, 0303 health sciences, epitope, allostery, exchange, Antibodies, Monoclonal, Deuterium Exchange Measurement, Isothermal titration calorimetry, Deuterium, microenvironment, 3. Good health, hydrogen-deuterium exchange, epitope mapping, Epitope mapping, Enzyme, chemistry, 030220 oncology & carcinogenesis, Biophysics, mass, Hydrogen–deuterium exchange

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fe5101105353d594f55bce98ca553Test
https://nrc-publications.canada.ca/eng/view/object/?id=b84f2488-1160-40b0-9ea8-e1ed0c1c57e9Test

المؤلفون: Kohei Tanaka, Jun Kondo, Masaru Miyagi, Shinko Watanabe, Taro Kishimoto

المصدر: Analytical chemistry. 93(45)

مصطلحات موضوعية: Drug, Chemistry, media_common.quotation_subject, HEK 293 cells, Deuterium Exchange Measurement, Deuterium, Analytical Chemistry, HEK293 Cells, Mechanism of action, Affinity chromatography, Covalent bond, Tandem Mass Spectrometry, medicine, Biophysics, Humans, Hydrogen–deuterium exchange, Chemical stability, Drug Interactions, Histidine, medicine.symptom, media_common, Chromatography, Liquid, Hydrogen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b6496dd8cebd387036d2012bc3674Test
https://pubmed.ncbi.nlm.nih.gov/34735131Test

المؤلفون: Michelle Kuhne, Richard Y.-C. Huang, Vangipuram S. Rangan, Yun Wang, Shrikant Deshpande, Mohan Srinivasan, Guodong Chen

المصدر: Analytical and Bioanalytical Chemistry. 412:1693-1700

مصطلحات موضوعية: medicine.drug_class, 02 engineering and technology, Monoclonal antibody, Major histocompatibility complex, 01 natural sciences, Biochemistry, Mass Spectrometry, Epitope, Analytical Chemistry, Natural killer cell, Electron Transport, medicine, Humans, Amino Acid Sequence, biology, Chemistry, Histocompatibility Antigens Class I, 010401 analytical chemistry, Antibodies, Monoclonal, Deuterium Exchange Measurement, 021001 nanoscience & nanotechnology, NKG2D, 0104 chemical sciences, Electron-transfer dissociation, stomatognathic diseases, medicine.anatomical_structure, Epitope mapping, biology.protein, Biophysics, Hydrogen–deuterium exchange, 0210 nano-technology, Epitope Mapping

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ffddbb3df0d56793789a069d253f87Test
https://doi.org/10.1007/s00216-020-02409-xTest

المؤلفون: Peng Cheng, Dong Long, Dan Liu, Daiwen Yang, Pin Xuan Chee

المصدر: Biophys J

مصطلحات موضوعية: Protein Folding, 0303 health sciences, Chemistry, Ligand, Biophysics, Deuterium Exchange Measurement, Articles, Nuclear magnetic resonance spectroscopy, Molecular Dynamics Simulation, Fatty Acid-Binding Proteins, Protein Structure, Secondary, Fatty acid-binding protein, Turn (biochemistry), 03 medical and health sciences, Molecular dynamics, 0302 clinical medicine, Protein structure, Helix, Humans, Protein folding, 030217 neurology & neurosurgery, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdfbba15706fa7c300ec129691edaf7Test
https://doi.org/10.1016/j.bpj.2019.06.012Test

المؤلفون: Tetsuo Torisu, Susumu Uchiyama, Kentaro Ishii, Takashi Tadokoro, Hiroaki Oyama, Katsumi Maenaka, Masanori Noda, Mika Yamauchi

المصدر: Journal of Pharmaceutical Sciences. 108:2323-2333

مصطلحات موضوعية: Models, Molecular, Hydrogen, Protein Conformation, Pharmaceutical Science, chemistry.chemical_element, 02 engineering and technology, Mass spectrometry, 030226 pharmacology & pharmacy, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Humans, Amino Acid Sequence, Peptide sequence, chemistry.chemical_classification, Antibodies, Monoclonal, Deuterium Exchange Measurement, Deuterium, 021001 nanoscience & nanotechnology, Fragment crystallizable region, Amino acid, Monomer, chemistry, Immunoglobulin G, Biophysics, Hydrogen–deuterium exchange, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432f9acd566bd4ca5eff4a8e1255cea2Test
https://doi.org/10.1016/j.xphs.2019.02.023Test