التفاصيل البيبلوغرافية
| العنوان: |
Emerging technologies for metabolite generation and structural diversification. |
| المؤلفون: |
Cusack, Kevin P.1 kevin.cusack@abbvie.com, Koolman, Hannes F.2, Lange, Udo E.W.3, Peltier, Hillary M.2, Piel, Isabel3, Vasudevan, Anil2 |
| المصدر: |
Bioorganic & Medicinal Chemistry Letters. Oct2013, Vol. 23 Issue 20, p5471-5483. 13p. |
| مصطلحات موضوعية: |
*METABOLITES, *MOLECULAR structure, *BIOLOGICAL systems, *BIOMIMETIC chemicals, *CATALYSIS, *ELECTROCHEMICAL analysis |
| مستخلص: |
Abstract: Multiple technologies have emerged for structural diversification and efficient production of metabolites of drug molecules. These include expanded use of enzymatic and bioorganic transformations that mimic biological systems, biomimetic catalysis and electrochemical techniques. As this field continues to mature the breadth of transformations is growing beyond simple oxidative processes due in part to parallel development of more efficient catalytic methods for functionalization of unactivated scaffolds. These technologies allow for efficient structural diversification of both aromatic and aliphatic substrates in many cases via single step reactions without the use of protecting groups. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
