دورية أكاديمية
Analysis of Corneal Deformation in Paediatric Patients Affected by Maturity Onset Diabetes of the Young Type 2
| العنوان: | Analysis of Corneal Deformation in Paediatric Patients Affected by Maturity Onset Diabetes of the Young Type 2 |
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| المؤلفون: | Michele Lanza, Enza Mozzillo, Rosa Boccia, Ludovica Fedi, Francesca Di Candia, Nadia Tinto, Paolo Melillo, Francesca Simonelli, Adriana Franzese |
| المصدر: | Diagnostics, Vol 13, Iss 8, p 1500 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | MODY2, diabetes, cornea, biomechanics, Corvis ST, Medicine (General), R5-920 |
| الوصف: | Background: To evaluate corneal deformation in Maturity Onset Diabetes of the Young type 2 (MODY2), paediatric subjects were analysed using a Scheimpflug-based device. The purpose of this analysis was to find new biomarkers for MODY2 disease and to gain a better understanding of the pathogenesis of the disease. Methods: A total of 15 patients with genetic and metabolic diagnoses of MODY2 (mean age 12.8 ± 5.66 years) and 15 age-matched healthy subjects were included. The biochemical and anthropometric data of MODY2 patients were collected from clinical records, and a complete ophthalmic check with a Pentacam HR EM-3000 Specular Microscope and Corvis ST devices was performed in both groups. Results: Highest concavity (HC) deflection length, Applanation 1 (A1) deflection amplitude, and A1 deflection area showed significantly lower values in MODY2 patients compared to healthy subjects. A significant positive correlation was observed between Body Mass Index (BMI) and HC deflection area and between waist circumference (WC) and the following parameters: maximum deformation amplitude, HC deformation amplitude, and HC deflection area. The glycosylated hemoglobin level (HbA1c) showed a significant positive correlation with Applanation 2 time and HC time. Conclusions: The obtained results show, for the first time, differences regarding corneal distortion features in the MODY2 population compared with healthy eyes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13081500 2075-4418 |
| العلاقة: | https://www.mdpi.com/2075-4418/13/8/1500Test; https://doaj.org/toc/2075-4418Test |
| DOI: | 10.3390/diagnostics13081500 |
| الوصول الحر: | https://doaj.org/article/af6fff0b42774703aa13881e36c3fa08Test |
| رقم الانضمام: | edsdoj.f6fff0b42774703aa13881e36c3fa08 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13081500 20754418 |
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| DOI: | 10.3390/diagnostics13081500 |