التفاصيل البيبلوغرافية
| العنوان: |
Anemia after Continuous-flow Left Ventricular Assist Device Implantation: Characteristics and Implications |
| المؤلفون: |
Amione-Guerra, Javier, Cruz-Solbes, Ana S., Bhimaraj, Arvind, Trachtenberg, Barry H., Pingali, Sai R., Estep, Jerry D., Park, Myung H., Guha, Ashrith |
| المصدر: |
The International Journal of Artificial Organs ; volume 40, issue 9, page 481-488 ; ISSN 0391-3988 1724-6040 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Biomedical Engineering, Biomaterials, General Medicine, Medicine (miscellaneous), Bioengineering |
| الوصف: |
Background Anemia is common in patients with heart failure and is associated with adverse outcomes. Management of anemia in CF-LVAD patients is not well studied. Our purpose is to characterize and identify the etiology of anemia in CF-LVAD patients. Secondary objectives are to describe the effect of CF-LVAD on pre-existing anemia and assess its impact after CF-LVAD support. Methods Cross-sectional study from January to July 2015 of ambulatory patients supported with a CF-LVAD for at least 6-months that presented with hemoglobin <12 g/dL and no recent gastrointestinal bleeding. Patients were classified as iron-deficient and non-iron-deficient and compared. Additionally, a retrospective analysis of 116 consecutive patients who underwent CF-LVAD from 2008 to 2013 with reported hemoglobin at 6 months as outpatients were divided into anemic or non-anemic and compared. Results In our cross-sectional cohort, iron deficiency was the most common cause of anemia. Notably, 49% of the iron-deficient patients were already on iron supplementation. In our retrospective cohort, 59% of the patients were anemic after 6 months of support. Anemic patients were older, had lower albumin, higher brain natriuretic peptide (BNP), worse renal function and New York Heart Association (NYHA) class. Anemia had a HR of 3.16 (95%CI 1.38–7.26) to predict a composite of 1-year death and HF readmissions, as well as HF-readmissions alone. Conclusions The most common cause of anemia in our study was iron-deficiency; almost half of the patients were iron deficient despite treatment, suggesting that oral iron may not be sufficient to reverse anemia. Anemia regardless of etiology was associated with adverse outcomes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.5301/ijao.5000607 |
| الإتاحة: |
https://doi.org/10.5301/ijao.5000607Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.7703CEB3 |
| قاعدة البيانات: |
BASE |
