دورية أكاديمية
The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study
| العنوان: | The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study |
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| المؤلفون: | Castro, Denisse, Valcarcel, Bryan, Runciman, Thanya, Huerta-Collado, Yesenia, Paredes, Sally, Beltran, Brady E, Castillo, Jorge J, Malpica, Luis |
| المصدر: | GW Authored Works |
| بيانات النشر: | Health Sciences Research Commons |
| سنة النشر: | 2023 |
| المجموعة: | George Washington University: Health Sciences Research Commons (HSRC) |
| مصطلحات موضوعية: | Biomarkers, T-cell, cohort studies, lymphoma, peripheral, prognosis, red cell distribution width |
| الوصف: | Readily accessible biomarkers for risk stratification in settings with limited resources are lacking. We evaluated the effect of high red distribution width-coefficient of variation (RDW-CV) values (>14%) on all-cause and lymphoma-specific mortality outcomes among 118 patients with peripheral T-cell lymphoma (PTCL) who received systemic treatment at two tertiary centers between 2010 and 2019. With a median follow-up of 45 months, patients with a high RDW-CV had a lower 4-year overall survival rate (34% vs. 45%, = 0.015) and higher cumulative incidence of lymphoma mortality (54% vs. 34%, = 0.007). RDW-CV >14% was associated with all-cause (adjusted Hazard Ratio [aHR] 1.98, 95% confidence interval [CI] 1.10-3.56) and lymphoma-specific mortality (aHR 2.64, 95% CI 1.32-5.29). In our study, RDW-CV emerges as an easily accessible and complementary prognostic biomarker for risk stratification among treated patients with PTCL. Further research should validate the predictive role of RDW-CV in prospective cohorts. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://hsrc.himmelfarb.gwu.edu/gwhpubs/3158Test; https://doi.org/10.1080/10428194.2023.2205975Test |
| DOI: | 10.1080/10428194.2023.2205975 |
| الإتاحة: | https://doi.org/10.1080/10428194.2023.2205975Test https://hsrc.himmelfarb.gwu.edu/gwhpubs/3158Test |
| رقم الانضمام: | edsbas.59826D11 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10428194.2023.2205975 |
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