التفاصيل البيبلوغرافية
| العنوان: |
Association of Cardiovascular Risk Factors With MRI Indices of Cerebrovascular Structure and Function and White Matter Hyperintensities in Young Adults |
| المؤلفون: |
Williamson, W, Lewandowski, AJ, Forkert, ND, Griffanti, L, Okell, TW, Betts, J, Boardman, H, Siepmann, T, McKean, D, Huckstep, O |
| المصدر: |
JAMA , 320 (7) pp. 665-673. (2018) |
| سنة النشر: |
2018 |
| المجموعة: |
University College London: UCL Discovery |
| مصطلحات موضوعية: |
Blood Vessels, Brain, Humans, Cardiovascular Diseases, Cholesterol, Magnetic Resonance Imaging, Body Mass Index, Risk Factors, Cross-Sectional Studies, Cerebrovascular Circulation, Physical Fitness, Adult, Female, Male, Young Adult, White Matter, Biomarkers |
| الوصف: |
Risk of stroke and brain atrophy in later life relate to levels of cardiovascular risk in early adulthood. However, it is unknown whether cerebrovascular changes are present in young adults.To examine relationships between modifiable cardiovascular risk factors and cerebrovascular structure, function, and white matter integrity in young adults.A cross-sectional observational study of 125 young adults (aged 18-40 years) without clinical evidence of cerebrovascular disease. Data collection was completed between August 2014 and May 2016 at the University of Oxford, United Kingdom. Final data collection was completed on May 31, 2016.The number of modifiable cardiovascular risk factors at recommended levels, based on the following criteria: body mass index (BMI) <25; highest tertile of cardiovascular fitness and/or physical activity; alcohol consumption <8 drinks/week; nonsmoker for >6 months; blood pressure on awake ambulatory monitoring <130/80 mm Hg; a nonhypertensive diastolic response to exercise (peak diastolic blood pressure <90 mm Hg); total cholesterol <200 mg/dL; and fasting glucose <100mg/dL. Each risk factor at the recommended level was assigned a value of 1, and participants were categorized from 0-8, according to the number of risk factors at recommended levels, with higher numbers indicating healthier risk categories.Cerebral vessel density, caliber and tortuosity, brain white matter hyperintensity lesion count. In a subgroup (n = 52), brain blood arrival time and cerebral blood flow assessed by brain magnetic resonance imaging (MRI).A total of 125 participants, mean (SD) age 25 (5) years, 49% women, with a mean (SD) score of 6.0 (1.4) modifiable cardiovascular risk factors at recommended levels, completed the cardiovascular risk assessment and brain MRI protocol. Cardiovascular risk factors were correlated with cerebrovascular morphology and white matter hyperintensity count in multivariable models. For each additional modifiable risk factor categorized as healthy, vessel density ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://discovery.ucl.ac.uk/id/eprint/10072130Test/ |
| الإتاحة: |
https://discovery.ucl.ac.uk/id/eprint/10072130Test/ |
| رقم الانضمام: |
edsbas.6C1B9AC4 |
| قاعدة البيانات: |
BASE |
