Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm
العنوان: | Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm |
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المؤلفون: | Jake Goldstein, Robert S Dieter, Vinod Bansal, Keaton Wieschhaus, Emily Bontekoe, Debra Hoppensteadt, Jawed Fareed |
المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022) Clinical and Applied Thrombosis/Hemostasis |
بيانات النشر: | SAGE Publications, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Male, Cardio-Renal Syndrome, Incidence, biomarkers, Original Manuscript, Hematology, General Medicine, Middle Aged, bleeding, United States, Fibrin Fibrinogen Degradation Products, bioassay, peripheral arterial disease, Renal Dialysis, Risk Factors, cardiology, RC666-701, Humans, Kidney Failure, Chronic, Diseases of the circulatory (Cardiovascular) system, atrial fibrillation, Female, Aged |
الوصف: | Background Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study profiled biomarkers and laboratory parameters of endothelium dysfunction in patients with ESRD, categorized by additional AFIB and PAD conditions. Methods Citrated blood samples were collected from 95 patients with ESRD. Biomarker levels were measured from plasma samples using sandwich ELISAs, including tissue plasminogen activator (tPA), D-dimer, and nitrotyrosine. Lab parameters, including BUN, calcium, creatinine, parathyroid hormone, phosphate, alkaline phosphatase, ferritin, transferrin, and total iron capacity, and patient comorbidities were obtained from patient medical records. The comorbidities were determined through provider notes, and evidence of applicable testing. Results 14.89% of patients were found to have atrial fibrillation (n = 14), 30.85% of patients were found to have peripheral arterial disease (n = 29), and 6.38% of patients were found to have both peripheral arterial disease and atrial fibrillation (n = 6). When compared to patients with only ESRD, patients with ESRD and PAD showed elevated levels of D-Dimer (p = .0314) and nitrotyrosine (p = .0330). When compared to patients with only ESRD, patients with atrial fibrillation showed elevated levels of D-Dimer (p = .0372), nitrotyrosine (p = .0322), and tPA (p = .0198). Conclusion When compared to patients with just ESRD, patients with concomitant PAD had elevated levels of Nitrotyrosine and D-dimer; while patients with concomitant Afib had elevated levels of nitrotyrosine, D-dimer, as well as tPA. |
تدمد: | 1938-2723 1076-0296 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be81b0998b4e0c956c54b0d422aef87dTest https://doi.org/10.1177/10760296211072820Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....be81b0998b4e0c956c54b0d422aef87d |
قاعدة البيانات: | OpenAIRE |
تدمد: | 19382723 10760296 |
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