التفاصيل البيبلوغرافية
| العنوان: |
KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. |
| المؤلفون: |
Renaud, S, Romain, B, Falcoz, P-E, Olland, A, Santelmo, N, Brigand, C, Rohr, S, Guenot, D, Massard, G |
| المصدر: |
British Journal of Cancer; 2/17/2015, Vol. 112 Issue 4, p720-728, 9p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
BIOMARKERS, MUTANT proteins, COLON cancer treatment, COLON cancer patients, METASTASIS |
| مستخلص: |
Background:We evaluated KRAS (mKRAS (mutant KRAS)) and BRAF (mBRAF (mutant BRAF)) mutations to determine their prognostic potential in assessing patients with colorectal cancer (CRC) for lung metastasectomy.Methods:Data were reviewed from 180 patients with a diagnosis of CRC who underwent a lung metastasectomy between January 1998 and December 2011.Results:Molecular analysis revealed mKRAS in 93 patients (51.7%), mBRAF in 19 patients (10.6%). In univariate analyses, overall survival (OS) was influenced by thoracic nodal status (median OS: 98 months for pN−, 27 months for pN+, P<0.0001), multiple thoracic metastases (75 months vs 101 months, P=0.008) or a history of liver metastases (94 months vs 101 months, P=0.04). mBRAF had a significantly worse OS than mKRAS and wild type (WT) (P<0.0001). The 5-year OS was 0% for mBRAF, 44% for mKRAS and 100% for WT, with corresponding median OS of 15, 55 and 98 months, respectively (P<0.0001). In multivariate analysis, WT BRAF (HR: 0.005 (95% CI: 0.001-0.02), P<0.0001) and WT KRAS (HR: 0.04 (95% CI: 0.02-0.1), P<0.0001) had a significant impact on OS.Conclusions:mKRAS and mBRAF seem to be prognostic factors in patients with CRC who undergo lung metastasectomy. Further studies are necessary. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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