Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis
| العنوان: | Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
|---|---|
| المؤلفون: | Vanessa Hax, Carlo Alberto Scirè, Eugenio Arrigoni, Enrico Fusaro, Giuseppe Paolazzi, Flavio Cesare Bodini, G. Lucchini, Daniele Santilli, Alessandro Volpe, Mario Silva, Alarico Ariani, Rafael Mendonça da Silva Chakr, Markus Bredemeier, Giuseppina Bertorelli, M. Saracco, E. Bravi, Emanuele Michieletti, Fabio De Gennaro, Emanuele Bacchini, Valeria Seletti, Maria De Santis, F. Girelli, F. Mozzani, Luca Idolazzi, D. Imberti, Veronica Alfieri, Federica Lumetti, Alfredo Chetta, Dilia Giuggioli, Cristian Caimmi, Simone Parisi, Nicola Sverzellati |
| المساهمون: | Ariani, A, Silva, M, Bravi, E, Parisi, S, Saracco, M, De Gennaro, F, Caimmi, C, Girelli, F, De Santis, M, Volpe, A, Lumetti, F, Hax, V, Bredemeier, M, Alfieri, V, Santilli, D, Bodini, F, Lucchini, G, Mozzani, F, Seletti, V, Bacchini, E, Arrigoni, E, Giuggioli, D, Chakr, R, Idolazzi, L, Bertorelli, G, Imberti, D, Michieletti, E, Paolazzi, G, Fusaro, E, Chetta, A, Scire, C, Sverzellati, N |
| المصدر: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS RMD Open |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, pulmonary fibrosi, systemic sclerosis, Kaplan-Meier Estimate, Gastroenterology, Scleroderma, Pulmonary function testing, 0302 clinical medicine, Pulmonary fibrosis, Prevalence, Immunology and Allergy, combined pulmonary fibrosis and emphysema, pulmonary fibrosis, semiquantitative chest CT, systemic sclerosis, skin and connective tissue diseases, Tomography, Lung function, combined pulmonary fibrosis and emphysema, pulmonary fibrosis, semiquantitative chest CT, Aged, Biomarkers, Female, Humans, Middle Aged, Prognosis, Pulmonary Emphysema, Pulmonary Fibrosis, Scleroderma, Systemic, Tomography, X-Ray Computed, Anticentromere antibodies, Enfisema pulmonar, integumentary system, respiratory system, Combined pulmonary fibrosis and emphysema, X-Ray Computed, medicine.anatomical_structure, Mortalidade, systemic sclerosi, Fibrose pulmonar idiopática, medicine.medical_specialty, Declaração de Helsinki, Estimativa de Kaplan-Meier, Immunology, Método, NO, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, In patient, 030203 arthritis & rheumatology, Lung, business.industry, Systemic, Escleroderma sistêmico, medicine.disease, respiratory tract diseases, 030228 respiratory system, business |
| الوصف: | ObjectivesThis multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease—ILD, emphysema or neither).MethodsChest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. PResultsWe enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (pConclusionsCPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e5019d76ebfc4bae646dbbe3738e4fTest http://hdl.handle.net/11392/2412524Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30e5019d76ebfc4bae646dbbe3738e4f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |