التفاصيل البيبلوغرافية
| العنوان: |
Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress. |
| المؤلفون: |
Ishida, Y.I.1, Kayama, T.2, Kibune, Y.2, Nishimoto, S.2, Koike, S.2, Suzuki, T.2, Horiuchi, Y.3, Miyashita, M.3, Itokawa, M.3, Arai, M.3, Ogasawara, Y.2 yo@my-pharm.ac.jp |
| المصدر: |
Biochemical & Biophysical Research Communications. Nov2017, Vol. 493 Issue 1, p573-577. 5p. |
| مصطلحات موضوعية: |
*PYRUVALDEHYDE, *ARGININE, *PROTEINS, *ERYTHROCYTES, *SCHIZOPHRENIA |
| مستخلص: |
Argpyrimidine (ARP) is an advanced glycation end product thought to be generated from a reaction between methylglyoxal and arginine residues in proteins. In this study, we observed marked accumulation of an approximately 56 kD protein, reactive to anti-ARP antibodies, in the red blood cells (RBCs) of some patients with refractory schizophrenia. This ARP-modified protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS. This is the first report of ARP-modified proteins accumulating in RBCs of patients with diseases involving carbonyl stress. We also observed high accumulation of ARP-modified SBP1 in the RBCs of patients with chronic kidney disease. Therefore, this modified protein may be a novel marker of carbonyl stress. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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