دورية أكاديمية
Engrailed 1 overexpression as a potential prognostic marker in Lower Grade Glioma
| العنوان: | Engrailed 1 overexpression as a potential prognostic marker in Lower Grade Glioma |
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| المؤلفون: | Jin Zhu, Yu-Qi Zhang |
| المصدر: | PeerJ, Vol 7, p e7414 (2019) |
| بيانات النشر: | PeerJ Inc., 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Engrailed 1, Lower grade glioma, Biomarker, Oncogene, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Background Engrailed 1 (EN1), as a member of homeobox-containing transcription factors, participates in the development of the brain. High expressions of EN1 exist in various tumors. However, the role of EN1 in lower grade glioma (LGG) is still unknown. Methods Coefficients of Cox regression were examined by data mining among 13 cancer types using OncoLnc to validate EN1 expressions in LGG patients from The Cancer Genome Atlas database (TCGA). Bioinformatic analysis was performed by using R2 and the UCSC Xena browser based on the data from 273 glioma cases in GSE16011 from GEO datasets and 530 cases of LGG patients in TCGA. Cases in GSE16011 were divided into two groups according to IDH1 mutation status. Cases in TCGA-LGG were classified to subtypes according to histopathological results, IDH1 mutation status and 1p19q status. The Kaplan–Meier survival curves were performed to analyze the relationship between EN1 expressions and clinicopathological characteristics and survival time respectively. Results Cox regression results showed that LGG was ranked statistically first among 13 different cancer types according to the false discovery rate (FDR) correction. Results from GSE16011 showed that: glioma, LGG and LGG with IDH1 mutation patients with high EN1 expressions had significantly shorter 5, 10, and 15-year overall survival time (OS) (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| العلاقة: | https://peerj.com/articles/7414.pdfTest; https://peerj.com/articles/7414Test/; https://doaj.org/toc/2167-8359Test |
| DOI: | 10.7717/peerj.7414 |
| الوصول الحر: | https://doaj.org/article/3ceb4c4b2cec404c890577b8e2249e0fTest |
| رقم الانضمام: | edsdoj.3ceb4c4b2cec404c890577b8e2249e0f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.7414 |