دورية أكاديمية
Potential Impact of Preoperative Circulating Biomarkers on Individual Escalating/de-Escalating Strategies in Early Breast Cancer
| العنوان: | Potential Impact of Preoperative Circulating Biomarkers on Individual Escalating/de-Escalating Strategies in Early Breast Cancer |
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| المؤلفون: | Gianni C., Palleschi M., Merloni F., Bleve S., Casadei C., Sirico M., Di Menna G., Sarti S., Cecconetto L., Mariotti M., De Giorgi U. |
| المساهمون: | Gianni C., Palleschi M., Merloni F., Bleve S., Casadei C., Sirico M., Di Menna G., Sarti S., Cecconetto L., Mariotti M., De Giorgi U. |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | biomarker, cfDNA, ctDNA, de-escalation, early breast cancer, escalation, fragmentomic, methylation, miRNA, neoadjuvant therapy |
| الوصف: | The research on non-invasive circulating biomarkers to guide clinical decision is in wide expansion, including the earliest disease settings. Several new intensification/de-intensification strategies are approaching clinical practice, personalizing the treatment for each patient. Moreover, liquid biopsy is revealing its potential with multiple techniques and studies available on circulating biomarkers in the preoperative phase. Inflammatory circulating cells, circulating tumor cells (CTCs), cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), and other biological biomarkers are improving the armamentarium for treatment selection. Defining the escalation and de-escalation of treatments is a mainstay of personalized medicine in early breast cancer. In this review, we delineate the studies investigating the possible application of these non-invasive tools to give a more enlightened approach to escalating/de-escalating strategies in early breast cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36612091; info:eu-repo/semantics/altIdentifier/wos/WOS:000909878900001; volume:15; issue:1; firstpage:1; lastpage:23; numberofpages:23; journal:CANCERS; https://hdl.handle.net/11585/965572Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145901222; https://www.mdpi.com/2072-6694/15/1/96Test |
| DOI: | 10.3390/cancers15010096 |
| الإتاحة: | https://doi.org/10.3390/cancers15010096Test https://hdl.handle.net/11585/965572Test https://www.mdpi.com/2072-6694/15/1/96Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8512CDF6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers15010096 |
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