نتائج البحث

1

Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1

المؤلفون: Jinu Lee, Eun-Ju Choi, Hyesung Lee, Taek-Yeol Jung, Seong Hun Lim, Do Sik Min

المصدر: Experimental & Molecular Medicine

مصطلحات موضوعية: endocrine system diseases, Amino Acid Motifs, Clinical Biochemistry, Regulator, Apoptosis, Phospholipase, environment and public health, Biochemistry, Article, Transactivation, Sirtuin 1, Genes, Reporter, Phospholipase D, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Lipid signalling, Molecular Biology, Etoposide, biology, Chemistry, PLD2, Cancer metabolism, Cell biology, Enzyme Activation, enzymes and coenzymes (carbohydrates), Gene Expression Regulation, Acetylation, biology.protein, Molecular Medicine, Histone deacetylase, Tumor Suppressor Protein p53, biological phenomena, cell phenomena, and immunity, hormones, hormone substitutes, and hormone antagonists, Protein Binding, Signal Transduction, Deacetylase activity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af85d0377dde57ef7822892f6c4b1334Test
https://doi.org/10.1038/s12276-021-00659-yTest

2

Structural visualization of transcription activated by a multidrug-sensing MerR family regulator

المؤلفون: David G. Schatz, Yangbo Hu, Baoyue Zhang, Ming Chen, Wei Zhou, Bin Liu, Yang Yang, Wei Shi, Chang Liu

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Protein Conformation, alpha-Helical, 0301 basic medicine, Transcription Elongation, Genetic, Science, Amino Acid Motifs, Genetic Vectors, Gene Expression, General Physics and Astronomy, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Bacterial Proteins, Bacterial transcription, Gene expression, Escherichia coli, Transcriptional regulation, Protein Interaction Domains and Motifs, Cloning, Molecular, Promoter Regions, Genetic, RNA polymerase II holoenzyme, Transcription Initiation, Genetic, Polymerase, Regulation of gene expression, Binding Sites, Multidisciplinary, Base Sequence, biology, Chemistry, Cryoelectron Microscopy, Promoter, DNA-Directed RNA Polymerases, Gene Expression Regulation, Bacterial, General Chemistry, Recombinant Proteins, Cell biology, DNA-Binding Proteins, 030104 developmental biology, biology.protein, Nucleic Acid Conformation, Protein Conformation, beta-Strand, 030217 neurology & neurosurgery, DNA, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4ef6faf78c3a83d49b24f80846a939Test
https://doaj.org/article/9c818f9780e14597af4ed38220cb42d1Test

3

The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN

المؤلفون: Aileen Park, Rachel Wilsey, Zhongqiang Qiu, Myeongwoo Lee, Lianzijun Wang

المصدر: Biochemical and Biophysical Research Communications. 586:143-149

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112db7cea5f2a62a331a08b8b47b22feTest
https://doi.org/10.1016/j.bbrc.2021.11.083Test

4

Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2

المؤلفون: Zhaoyuan Hou, Hai Gao, Liang Zhang, Pan Zhang, Houwen Lin, Lin Zhang

المصدر: Biochemical and Biophysical Research Communications. 586:1-7

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Genetic Vectors, Phosphoadenosine Phosphosulfate, Biophysics, Gene Expression, Phenylalanine, Crystallography, X-Ray, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Adenosine Triphosphate, Sulfation, Multienzyme Complexes, Catalytic Domain, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, chemistry.chemical_classification, Sequence Homology, Amino Acid, ATP synthase, biology, Drug discovery, Substrate (chemistry), Cell Biology, Recombinant Proteins, Sulfate Adenylyltransferase, Neoplasm Proteins, 3'-Phosphoadenosine-5'-phosphosulfate, Enzyme, chemistry, biology.protein, Thermodynamics, Protein Conformation, beta-Strand, Sequence Alignment, Function (biology), Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd5b658bcb55b0905877c0f5eaa23b0Test
https://doi.org/10.1016/j.bbrc.2021.11.062Test

5

Dimeric architecture of maltodextrin glucosidase (MalZ) provides insights into the substrate recognition and hydrolysis mechanism

المؤلفون: Eui-Jeon Woo, Yan An, Kyung-Mo Song, Byung-Ha Oh, Su-Jin Lee, Jong-Tae Park, Woo-Chan Ahn, Kwang-Hyun Park

المصدر: Biochemical and Biophysical Research Communications. 586:49-54

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Glycoside Hydrolases, Stereochemistry, Genetic Vectors, Biophysics, Gene Expression, Crystallography, X-Ray, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Residue (chemistry), Hydrolysis, Polysaccharides, Catalytic Domain, Escherichia coli, Protein Interaction Domains and Motifs, Cloning, Molecular, Molecular Biology, chemistry.chemical_classification, biology, Escherichia coli Proteins, Active site, Substrate (chemistry), Cell Biology, Protein engineering, Maltose, Maltodextrin, Recombinant Proteins, Glucose, Enzyme, chemistry, Biocatalysis, biology.protein, Protein Conformation, beta-Strand, Protein Multimerization, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fbaece6777e83987ef01a4ce30c562Test
https://doi.org/10.1016/j.bbrc.2021.11.070Test

6

Emerging mutation patterns in SARS-CoV-2 variants

المؤلفون: David A. Ostrov, Glenn W. Knox

المصدر: Biochemical and Biophysical Research Communications

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5785fcd850d8838e58fcc090a9cfe692Test
https://doi.org/10.1016/j.bbrc.2021.11.059Test

7

Docosahexaenoic acid-containing phosphatidic acid interacts with clathrin coat assembly protein AP180 and regulates its interaction with clathrin

المؤلفون: Fumio Sakane, Fumi Hoshino

المصدر: Biochemical and Biophysical Research Communications

مصطلحات موضوعية: WT, wild type, Diacylglycerol kinase, PG, phosphatidylglycerol, Biochemistry, GST, glutathione S-transferase, WB, Western blotting, PC, phosphatidylcholine, Mice, chemistry.chemical_compound, Phosphatidic acid, AP180, PA, phosphatidic acid, Receptor, Internalization, media_common, PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate, biology, Chol, cholesterol, Brain, PS, phosphatidylserine, Clathrin-mediated endocytosis, Endocytosis, Recombinant Proteins, Cell biology, Docosahexaenoic acid, DGK, diacylglycerol kinase, Monomeric Clathrin Assembly Proteins, Phosphatidylinositol 4,5-bisphosphate, AD, Alzheimer's disease, Protein Binding, CL, cardiolipin, Docosahexaenoic Acids, media_common.quotation_subject, Biophysics, Phosphatidic Acids, CME, clathrin-mediated endocytosis, PE, phosphatidylethanolamine, Clathrin, Article, PI, phosphatidylinositol, Cell Line, CID, C-terminal intrinsically disordered region, Animals, Humans, Protein Interaction Domains and Motifs, Phosphatidylinositol, PLD, phospholipase D, Molecular Biology, Binding Sites, CHC, clathrin heavy chain, Host Microbial Interactions, SARS-CoV-2, COVID-19, Cell Biology, Virus Internalization, CBB, Coomassie Brilliant Blue, chemistry, Clathrin coat assembly protein AP180, biology.protein, Ap180, ANTH, AP180 N-terminal homology domain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486bafc8e128e9f14b907481315a7d43Test
https://doi.org/10.1016/j.bbrc.2021.11.097Test

8

Consensus mutagenesis and computational simulation provide insight into the desaturation catalytic mechanism for delta 6 fatty acid desaturase

المؤلفون: Xin Tang, Jie Cui, Hao Zhang, Haiqin Chen, Wei Chen, Yong Q. Chen

المصدر: Biochemical and Biophysical Research Communications. 586:74-80

مصطلحات موضوعية: Fatty Acid Desaturases, Protein Conformation, Genetic Vectors, Saccharomyces cerevisiae, Biophysics, Gene Expression, Biochemistry, Substrate Specificity, Linoleic Acid, Chlorophyta, Catalytic Domain, Protein Interaction Domains and Motifs, Amino Acid Sequence, Cloning, Molecular, Site-directed mutagenesis, Molecular Biology, chemistry.chemical_classification, Sequence Homology, Amino Acid, biology, Algal Proteins, Mutagenesis, Cell Biology, biology.organism_classification, Recombinant Proteins, Delta-6-desaturase, Amino acid, Molecular Docking Simulation, Fatty acid desaturase, Enzyme, chemistry, Biocatalysis, Mutagenesis, Site-Directed, biology.protein, Sequence Alignment, Protein Binding, Polyunsaturated fatty acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d984428468ee726d4a5bcc5823604a86Test
https://doi.org/10.1016/j.bbrc.2021.11.050Test

9

Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides

المؤلفون: Xinyu Xu, Yi Lin, Wei Cheng, Dan Ke, Yujie Chen, Yuquan Wei, Jinzhu Zhang, Jie Zhou, Minghai Tang, Jianxiong He, Haohao Dong, Wenxian Yang, Xiaofeng Zhu, James H. Naismith

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Glycosylation, Glycobiology, General Physics and Astronomy, Gene Expression, Steviol, Protein Engineering, Substrate Specificity, chemistry.chemical_compound, 0302 clinical medicine, Glucosides, Catalytic Domain, Stevia, Plant Proteins, 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, biology, Recombinant Proteins, Biochemistry, Carbohydrate Sequence, Taste, Enzyme mechanisms, Diterpenes, Kaurane, Steviol glycoside, Protein Binding, Uridine Diphosphate Glucose, Glycan, Science, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Glycosyltransferase, Humans, Protein Interaction Domains and Motifs, 030304 developmental biology, X-ray crystallography, Glycoside, Glycosyltransferases, Oryza, General Chemistry, Stevia rebaudiana, Kinetics, Enzyme, Aglycone, Glucose, chemistry, Sweetening Agents, biology.protein, Biocatalysis, Protein Conformation, beta-Strand, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537f0f7b9ff33f516d2e537af2a0991bTest
https://doaj.org/article/3992bcac521a4b928331e2b513baaeabTest

10

Structural insights revealed by crystal structures of CYP76AH1 and CYP76AH1 in complex with its natural substrate

المؤلفون: Lixin Huang, Lei Zhang, Xiaonan Huang, Mingyue Gu, Zhangxin Chen, Ke He, Luqi Huang, Jie Deng, Zhenzhan Chang, Chao Shi, Juan Guo

المصدر: Biochemical and Biophysical Research Communications. 582:125-130

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Stereochemistry, Genetic Vectors, Biophysics, Gene Expression, Secondary Metabolism, Salvia miltiorrhiza, Crystal structure, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Catalysis, Synthetic biology, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Biosynthesis, Escherichia coli, Protein Interaction Domains and Motifs, Cloning, Molecular, Molecular Biology, Plant Proteins, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Substrate (chemistry), Cytochrome P450, Cell Biology, Recombinant Proteins, Enzyme, Abietanes, biology.protein, Protein Conformation, beta-Strand, Diterpenes, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772b9763107b874e55a5b8757a254bb6Test
https://doi.org/10.1016/j.bbrc.2021.10.004Test

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