التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide DNA methylation profiling of blood from monozygotic twins discordant for myocardial infarction |
| المؤلفون: |
Marco Morselli, Aylin Köseler, Matteo Pellegrini, Feiyang Ma, Oguz Kilic, Ismail Dogu Kilic |
| المصدر: |
In vivo (Athens, Greece), vol 34, iss 1 |
| بيانات النشر: |
International Institute of Anticancer Research, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Male, Cancer Research, genomic DNA, Twins, Myocardial Infarction, microsomal triglyceride transfer protein, multidetector computed tomography, Cardiovascular, Microsomal triglyceride transfer protein, anterior myocardial infarction, Epigenesis, Genetic, genetic background, 0302 clinical medicine, aspartate aminotransferase, SEC14 like lipid binding 2, T lymphocyte, apolipoprotein B, echocardiography, genetics, Promoter Regions, Genetic, genome analysis, Genetics, clinical article, Genome, DNA methylation, reduced representation bisulfite sequencing, adult, iron sulfur cluster assembly enzyme, neutrophil, Methylation, gene expression regulation, Cardiovascular disease, carboxylesterase 1, Prognosis, unclassified drug, Heart Disease, Phenotype, CpG site, fatty acid metabolism, twin discordance, 030220 oncology & carcinogenesis, monocyte, Epigenetics, acyl coenzyme A synthetase family member 3, genetic marker, Research Article, Genetic Markers, gene locus, Carboxylesterase 1, electrocardiography, Clinical Sciences, heart infarction, Biology, General Biochemistry, Genetics and Molecular Biology, Article, genetic epigenesis, Monozygotic, Promoter Regions, enzyme blood level, 03 medical and health sciences, carboxylesterase 1 pseudogene 1, monozygotic twins, promoter region, Genetic, blood, human genome, gene expression profiling, case report, Humans, Oncology & Carcinogenesis, human, acyl coenzyme A synthetase medium chain family member 2A, Heart Disease - Coronary Heart Disease, Pharmacology, B lymphocyte, creatine kinase, Genome, Human, human cell, percutaneous coronary intervention, lactate dehydrogenase, Twins, Monozygotic, Twin study, lipid droplet associated hydrolase, enzyme, Differentially methylated regions, acyl coenzyme A synthetase medium chain family member 5, biology.protein, cholesterol metabolism, CpG island, AFG3 like matrix AAA peptidase subunit 2, hydrolase, coronary artery obstruction, Epigenesis |
| الوصف: |
Background/Aim: This study aimed to measure the DNA methylation state of thousands of CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular disease (CVD). Twin 1 had suffered myocardial infarction, while the other was healthy. Patients and Methods: Since the aim of this study was to identify differentially methylated regions which might act as potential markers, reduced-representation bisulfite libraries were used for whole-genome methylation analysis. Results: According to the analysis, 11 genes lipid droplet associated hydrolase (LDAH), apolipoprotein B (APOB), acyl-CoA synthetase medium chain family member 2A (ACSM2A), acyl-CoA synthetase medium chain family member 5(ACSM5), acyl-CoA synthetase family member 3 (ACSF3), carboxylesterase 1 (CES1), carboxylesterase 1 pseudogene 1 (CES1P1), AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), iron-sulfur cluster assembly enzyme (ISCU), SEC14 like lipid binding 2 (SEC14L2) and microsomal triglyceride transfer protein (MTTP) were all hypomethylated in DNA from twin 2, the unaffected twin. Methylation changes were observed at different multiple loci between the twins, suggesting loci that are affected by disease status in identical genetic backgrounds. Conclusion: This twin study may contribute significantly to the understanding of the genetic basis of CVD and resulting myocardial infarction. This approach may allow identification of possible target loci associated with aberrant epigenetic regulation in CVD. © 2020 International Institute of Anticancer Research. All rights reserved. |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cb2c54ba67a102c40f00d3e1e8a8b7Test
https://hdl.handle.net/11499/37524Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....82cb2c54ba67a102c40f00d3e1e8a8b7 |
| قاعدة البيانات: |
OpenAIRE |
