المؤلفون: Marinella Roberti, Elisa Giacomini, Alfonso Ciotta, Angela Nebbioso, Maurizio Recanatini, Federico Falchi, Rosaria Maria Pipitone, Antonietta Di Cristina, Stefania Grimaudo, Lucia Altucci, Cristina Ianni, Manlio Tolomeo

المساهمون: Giacomini, E, Nebbioso, Angela, Ciotta, A, Ianni, C, Falchi, F, Roberti, M, Tolomeo, M, Grimaudo, S, Cristina, Ad, Pipitone, Rm, Altucci, Lucia, Recanatini, M., Giacomini E, Nebbioso A, Ciotta A, Ianni C, Falchi F, Roberti M, Tolomeo M, Grimaudo S, Cristina AD, Pipitone RM, Altucci L, Recanatini M, Nebbioso, A, Cristina, AD, Pipitone, RM, Altucci, L, Recanatini, M

المصدر: ACS medicinal chemistry letters 5 (2014): 973–978. doi:10.1021/ml5000959
info:cnr-pdr/source/autori:Giacomini E.; Nebbioso A.; Ciotta A.; Ianni C.; Falchi F.; Roberti M.; Tolomeo M.; Grimaudo S.; Cristina A.D.; Pipitone R.M.; Altucci L.; Recanatini M./titolo:Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity/doi:10.1021%2Fml5000959/rivista:ACS medicinal chemistry letters/anno:2014/pagina_da:973/pagina_a:978/intervallo_pagine:973–978/volume:5

مصطلحات موضوعية: Multifunctional ligands, Cell cycle progression, HDAC inhibition, Inhibitory postsynaptic potential, Biochemistry, Settore BIO/13 - Biologia Applicata, HDAC, Drug Discovery, medicine, Cytotoxic T cell, antiproliferative activity, chimeric compound, stilbene, Cancer, biology, Chemistry, ANTIPROLIFERATIVE ACTIVITY, Organic Chemistry, multifunctional ligand, medicine.disease, Combinatorial chemistry, Settore CHIM/08 - Chimica Farmaceutica, Histone, STILBENES, biology.protein, HDAC INHIBITORS, Epigenetics, Histone deacetylase, Chimeric molecules

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8400fb57406fd3b5910977b29cad4c5bTest
http://hdl.handle.net/11591/197955Test

المؤلفون: Nicola Gebbia, Maria Meli, Antonietta Di Cristina, M. Katherine Jung, Daniele Simoni, Francesco Paolo Invidiata, Luisa Dusonchet, Stefania Grimaudo, Lucia Crosta, Marinella Roberti, Laura Piccagli, Ernest Hamel, Giuseppina Grisolia, Riccardo Rondanin, Giuseppe Giannini, Marcello Rossi, Manlio Tolomeo, Vincenzo Abbadessa, Riccardo Baruchello, Romeo Simgma-Tau Ind. Farm. Riunite Spa Romagnoli

المساهمون: SIMONI D, GRISOLIA G, GIANNINI G, ROBERTI M, RONDANIN R, PICCAGLI L, BARUCHELLO R, ROSSI M, ROMAGNOLI R, INVIDIATA FP, GRIMAUDO S, JUNG MK, HAMEL E, GEBBIA N, CROSTA L, ABBADESSA V, DI CRISTINA A, DUSONCHET L, MELI M, TOLOMEO M, Simoni D., Grisolia G., Giannini G., Roberti M., Rondanin R., Piccagli L., Baruchello R., Rossi M., Romagnoli R., Invidiata F. P., Grimaudo S., Jung M. K., Hamel E., Gebbia N., Crosta O. L., Abbadessa. O. V., Di Cristina A., Dusonchet L., Meli M., Tolomeo M.

مصطلحات موضوعية: Models, Molecular, A-4 ANALOGS, Double bond, HL60, Stereochemistry, Pyridines, TUBULIN, Apoptosis, ANTINEOPLASTIC AGENTS, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Stilbenes, Benzene Derivatives, Humans, Isoxazole, BIOLOGICAL EVALUATION, Cytotoxicity, chemistry.chemical_classification, Combretastatin, biology, COLCHICINE, DEATH, Isoxazoles, Drug Resistance, Multiple, Tubulin, ANTIMITOTIC ANTITUMOR AGENTS, MULTIDRUG, chemistry, Cell culture, Drug Resistance, Neoplasm, DISCOVERY, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, SOLID TUMOR-THERAPY

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c2422c00700047c59b7a8bd4547d84Test
http://hdl.handle.net/10447/15628Test

المؤلفون: Riccardo Rondanin, Marinella Roberti, Marcello Rossi, Silvia Marino, Valerio Bertolasi, Stefania Merighi, Daniele Simoni, Stefania Grimaudo, Daniela Pizzirani, Anna Siniscalchi, Pier Andrea Borea, Katia Varani, Manlio Tolomeo, Stefania Gessi, Francesco Paolo Invidiata, Riccardo Baruchello, Sabrina Cavallini, Clementina Bianchi

المساهمون: SIMONI D, ROSSI M, BERTOLASI V, ROBERTI M, PIZZIRANI D, RONDANIN R, BARUCHELLO R, INVIDIATA FP, TOLOMEO M, GRIMAUDO S, MERIGHI S, VARANI K, GESSI S, BOREA PA, MARINO S, CAVALLINI S, BIANCHI C, SINISCALCHI A, Simoni D., Rossi M., Bertolasi V., Roberti M., Pizzirani D., Rondanin R., Baruchello R., Invidiata F. P., Tolomeo M., Grimaudo S., Merighi S., Varani K., Gessi S., Borea P. A., Marino S., Cavallini S., Bianchi C., Siniscalchi A.

مصطلحات موضوعية: Stereochemistry, Dopamine, Dopamine Plasma Membrane Transport Proteins, Molecular Conformation, Nerve Tissue Proteins, In Vitro Techniques, Binding, Competitive, Dopamine Plasma Membrane Transport Protein, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Dopamine Uptake Inhibitors, Cocaine, triple reuptake, Drug Discovery, medicine, Animals, Structure–activity relationship, Dopamine transporter, Benztropine, Nerve Endings, Membrane Glycoproteins, biology, Putamen, Membrane Transport Proteins, Stereoisomerism, Tropane, Biological activity, Corpus Striatum, Rats, chemistry, biology.protein, Molecular Medicine, Tropanes, medicine.drug

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ebb8688abc561b14eb5208f3f5ff23Test
http://hdl.handle.net/10447/14975Test

المؤلفون: Umberto Contaldo, Marinella Roberti, Francesco Musiani, Greta Bagnolini, Michele Cianci, Luca Mazzei, Stefano Ciurli

المساهمون: Mazzei L., Contaldo U., Musiani F., Cianci M., Bagnolini G., Roberti M., Ciurli S., Department of Pharmacy and Biotechnologies (FABIT), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, Viale Giuseppe Fanin, 40, 40127 Bologna, Italy, BioEnergie et Environnement (BEE), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche [Ancona] (UNIVPM)

المصدر: Angewandte Chemie / International edition 60(11), 6029-6035 (2020). doi:10.1002/anie.202014706
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (11), pp.6029-6035. ⟨10.1002/anie.202014706⟩
Angewandte Chemie International Edition, 2021, 60 (11), pp.6029-6035. ⟨10.1002/anie.202014706⟩

مصطلحات موضوعية: Models, Molecular, Reaction mechanism, Sporosarcina, Urease, Catechols, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Catalysis, Autocatalysis, chemistry.chemical_compound, nickel, Sulfanyl, Reactivity (chemistry), Sulfhydryl Compounds, Enzyme Inhibitors, enzyme inhibition, Density Functional Theory, chemistry.chemical_classification, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, urease, Catechol, Molecular Structure, biology, 010405 organic chemistry, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, General Medicine, catechol, biology.organism_classification, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Kinetics, chemistry, Canavalia ensiformis, [SDV.TOX]Life Sciences [q-bio]/Toxicology, ddc:540, Thiol, biology.protein, quantum-mechanical calculations, atechols, quantum-mechanical calculation

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06291343a37b72ce31f138c4773ce99cTest
https://bib-pubdb1.desy.de/record/453695Test

المؤلفون: Letizia Scandiffio, Claudia Zanna, Michela Rugolo, Jessica Fiori, Stefan Steimle, Fevzi Daldal, Serena J. Aleo, Marina Roberti, Aldo Roda, Paola Loguercio Polosa, Anna Ghelli, Valerio Carelli, Emanuele Porru, Concetta Valentina Tropeano

المساهمون: Tropeano C.V., Aleo S.J., Zanna C., Roberti M., Scandiffio L., Loguercio Polosa P., Fiori J., Porru E., Roda A., Carelli V., Steimle S., Daldal F., Rugolo M., Ghelli A.

المصدر: Biochim Biophys Acta Bioenerg

مصطلحات موضوعية: 0301 basic medicine, N-acetylcysteine, rotenone, Biophysics, MT-CYB gene in-frame microdeletion, Mitochondrion, medicine.disease_cause, Biochemistry, Article, Electron Transport Complex IV, 03 medical and health sciences, chemistry.chemical_compound, Electron Transport Complex III, 0302 clinical medicine, Adenosine Triphosphate, Oxygen Consumption, Rotenone, medicine, Animals, Mutation, Electron Transport Complex I, ATP synthase, biology, Animal, Cell Biology, Mitochondria, Respiratory chain supercomplexe, 030104 developmental biology, chemistry, Cytochrome b depletion complex III dysfunction, Coenzyme Q – cytochrome c reductase, Respirasome, Mitochondrial Membranes, biology.protein, Mitochondrial Membrane, lipids (amino acids, peptides, and proteins), Adenosine triphosphate, Oxidation-Reduction, 030217 neurology & neurosurgery, Gene Deletion

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a188689001c1f1bfd2404aac9948a74Test
https://pubmed.ncbi.nlm.nih.gov/31825807Test

المؤلفون: Marinella Roberti, Rosa Buonfiglio, Yuhong Wang, Gea-Ny Tseng, Matteo Masetti, Elisa Giacomini, Maurizio Recanatini

المساهمون: Giacomini, E., Buonfiglio, R., Masetti, M., Wang, Y., Tseng, G.-N., Roberti, M., Recanatini, M., DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE, Facolta' di FARMACIA, Da definire, AREA MIN. 03 - Scienze chimiche

المصدر: Scopus-Elsevier

مصطلحات موضوعية: ERG1 Potassium Channel, ligand-based virtual screening, hERG, Activators, electrophysiology, hERG potassium channel, ligand-based virtual screening, NS1643, parallel synthesis, hERG potassium channel, Computational biology, parallel synthesis, Ligands, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Potassium Channel Blockers, medicine, Humans, cardiovascular diseases, Activators, Virtual screening, Molecular Structure, biology, Chemistry, Organic Chemistry, NS1643, General Medicine, electrophysiology, Ligand (biochemistry), Small molecule, Combinatorial chemistry, Ether-A-Go-Go Potassium Channels, Potassium channel, High-Throughput Screening Assays, Computer Science Applications, Mechanism of action, biology.protein, medicine.symptom, Function (biology), Communication channel

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5caadeea54ad248f6a5d532111b973Test
http://hdl.handle.net/11585/517284Test

المؤلفون: Marinella Roberti, Andrea Cavalli, Matteo Masetti, John S. Mitcheson, Maurizio Recanatini, Michael W. Y. Chang, Rosa Buonfiglio, Luisa Ceccarini, Cristina Ianni, Rachel E. Caves

المساهمون: Cavalli A., Buonfiglio R., Ianni C., Masetti M., Ceccarini L., Caves R., Chang M.W., Mitcheson J.S., Roberti M., Recanatini M.

مصطلحات موضوعية: cardiac toxicity, congenital, hereditary, and neonatal diseases and abnormalities, hERG, Quantitative Structure-Activity Relationship, Computational biology, Pharmacology, Blocking (statistics), 03 medical and health sciences, 0302 clinical medicine, Cardiac toxicity, Drug Discovery, Potassium Channel Blockers, Humans, Computational design, cardiovascular diseases, 030304 developmental biology, 0303 health sciences, biology, Chemistry, food and beverages, Ether-A-Go-Go Potassium Channels, 3. Good health, Long QT Syndrome, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, DRUG DESIGN

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a39007248c54cc836193e8b6af02bTest
http://hdl.handle.net/11585/117144Test

المؤلفون: Marinella Roberti, Marina Vettraino, Luigi Fiume, Andrea Sartini, Rosa Buonfiglio, Marcella Manerba, Elisa Giacomini, Maurizio Recanatini, Giuseppina Di Stefano

المساهمون: Manerba M., Vettraino M., Fiume L., Di Stefano G., Sartini A., Giacomini E., Buonfiglio R., Roberti M., Recanatini M.

المصدر: ChemMedChem. 7(2)

مصطلحات موضوعية: Cellular respiration, Inibitori di LDH, Apoptosis, Biology, Biochemistry, Cofactor, Metabolismo delle cellule tumorali, Cell Line, chemistry.chemical_compound, Lactate dehydrogenase, Drug Discovery, medicine, Humans, Protein Isoforms, Glycolysis, Computer Simulation, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Binding Sites, L-Lactate Dehydrogenase, Organic Chemistry, Hydrogen Bonding, Metabolism, Molecular biology, Protein Structure, Tertiary, Enzyme Activation, Kinetics, Enzyme, chemistry, Mechanism of action, Isocoumarins, Anaerobic glycolysis, biology.protein, Molecular Medicine, medicine.symptom

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52594fea085c0166fb7bde4fb9dd1e9Test
https://pubmed.ncbi.nlm.nih.gov/22052811Test

المؤلفون: Xulin Xu, Gea-Ny Tseng, Marinella Roberti, Maurizio Recanatini

المساهمون: Xu X., Recanatini M., Roberti M., Tseng G.-N.

مصطلحات موضوعية: Male, Stereochemistry, Xenopus, hERG, Guinea Pigs, Peptide, Isoindoles, Article, Cell membrane, chemistry.chemical_compound, Cresols, Chlorocebus aethiops, medicine, Animals, Humans, Binding site, Pharmacology, chemistry.chemical_classification, Trifluoromethyl, Binding Sites, biology, Activator (genetics), Phenylurea Compounds, Nicotinic Acids, Ether-A-Go-Go Potassium Channels, medicine.anatomical_structure, Membrane, chemistry, COS Cells, biology.protein, Molecular Medicine, Female, Cysteine

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f952bf2b2d1b4e75348e3f8b6d358Test
https://europepmc.org/articles/PMC3888322Test/