Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection
| العنوان: | Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection |
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| المؤلفون: | Antonio Riva, Matthew L. Albert, Nikolai V. Naoumov, Roger Williams, Arvydas Ambrozaitis, Armanda Casrouge, Melissa E. Laird, Shilpa Chokshi |
| المساهمون: | Institute of Hepatology, Birkbeck College [University of London]-Foundation for Liver Research, Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Vilnius University [Vilnius], Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Hepatology Hepatology, Wiley-Blackwell, 2014, 60 (2), pp.487-496. ⟨10.1002/hep.27139⟩ Hepatology, 2014, 60 (2), pp.487-496. ⟨10.1002/hep.27139⟩ |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | MESH: T-Lymphocytes/metabolism, Male, Chemokine, T-Lymphocytes, MESH: Adaptive Immunity/immunology, MESH: Hepatitis C, Chronic/virology, Adaptive Immunity, medicine.disease_cause, MESH: Chemokine CXCL10/immunology, Pathogenesis, MESH: Immunity, Innate/immunology, MESH: Killer Cells, Natural/virology, MESH: Interferon-gamma/metabolism, Longitudinal Studies, Prospective Studies, Prospective cohort study, MESH: Longitudinal Studies, MESH: Middle Aged, biology, virus diseases, Hepatitis C, MESH: Follow-Up Studies, Middle Aged, 3. Good health, Interleukin-10, Killer Cells, Natural, MESH: Chemokine CXCL10/blood, MESH: Young Adult, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, MESH: Interleukin-10/immunology, MESH: Dipeptidyl Peptidase 4/immunology, Adult, medicine.medical_specialty, MESH: T-Lymphocytes/virology, MESH: Interferon-gamma/immunology, Hepatitis C virus, Dipeptidyl Peptidase 4, Interferon-gamma, Young Adult, Immunity, Internal medicine, MESH: T-Lymphocytes/immunology, medicine, CXCL10, Humans, MESH: Interleukin-10/metabolism, MESH: Hepatitis C, Chronic/immunology, MESH: Humans, MESH: Killer Cells, Natural/metabolism, Hepatology, MESH: Adult, Hepatitis C, Chronic, medicine.disease, MESH: Male, MESH: Prospective Studies, Immunity, Innate, Chemokine CXCL10, MESH: Killer Cells, Natural/immunology, Immunology, biology.protein, MESH: Dipeptidyl Peptidase 4/metabolism, MESH: Female, Follow-Up Studies |
| الوصف: | The pathogenesis of hepatitis C virus (HCV) infection is strongly influenced by the nature of the host's antiviral immunity. Counterintuitively, elevated serum concentrations of C-X-C chemokine 10 (CXCL10), a potent chemoattractant for antiviral T-cells and NK-cells, are associated with poor treatment outcomes in patients with chronic HCV. It has been reported that an N-terminal truncated form of CXCL10, generated by the protease dipeptidylpeptidase 4 (DPP4), can act as chemokine antagonist. We sought to investigate CXCL10 antagonism in the clinical outcome and evolution of acute HCV infection. We collected serial blood samples from 16 patients, at the clinical onset of acute HCV infection and at 12 standardized follow-up timepoints over the first year. Intact and truncated CXCL10 and DPP4 activity were quantified in all longitudinal samples. In addition, NK-cell frequency/phenotype, and HCV-specific T-cell responses were assessed. Subjects developing chronicity (n = 11) had higher concentrations of CXCL10 (P |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776ea249388107e90f11a30f2413cbf5Test https://pubmed.ncbi.nlm.nih.gov/24668726Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....776ea249388107e90f11a30f2413cbf5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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