المؤلفون: Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams

المصدر: Frontiers in Cell and Developmental Biology
Likhatcheva, M, Gieling, R G, Brown, J A L, Demonacos, C & Williams, K J 2021, ' A Novel Mechanism of Ataxia Telangiectasia Mutated Mediated Regulation of Chromatin Remodeling in Hypoxic Conditions ', Frontiers in cell and developmental biology, vol. 9, 720194 . https://doi.org/10.3389/fcell.2021.720194Test
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: Methyltransferase, QH301-705.5, SUV39H1, Chromatin remodeling, Cell and Developmental Biology, MDM2, medicine, Epigenetics, Ataxia Telangiectasia Mutated (ATM), Biology (General), Original Research, biology, Kinase, Chemistry, hypoxia, C100, C500, Cell Biology, Hypoxia (medical), Cell biology, Histone, Tip60, biology.protein, Mdm2, medicine.symptom, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9672b25273a95a83e12e04976a2f0900Test
https://pubmed.ncbi.nlm.nih.gov/34621741Test

المؤلفون: Marianne Ashford, Ian J. Stratford, Julio M. Rios de la Rosa, Alice Spadea, Nicola Tirelli, Manal Mehibel, Annalisa Tirella, Kaye J. Williams

المصدر: Molecular Pharmaceutics. 16:2481-2493

مصطلحات موضوعية: Gene isoform, media_common.quotation_subject, Cell, Pharmaceutical Science, 02 engineering and technology, Biology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Hyaluronic acid, medicine, Humans, Hyaluronic Acid, Receptor, Internalization, media_common, CD44, Cancer, Flow Cytometry, 021001 nanoscience & nanotechnology, medicine.disease, Immunohistochemistry, 3. Good health, Hyaluronan Receptors, medicine.anatomical_structure, chemistry, Cancer cell, biology.protein, Cancer research, Molecular Medicine, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95e7d6baf0e17192457056c7c67ee96Test
https://doi.org/10.1021/acs.molpharmaceut.9b00083Test

المؤلفون: Hannah J. Gregson, Kay Marshall, Stephen A Roberts, Sarah Kitson, Vanitha N Sivalingam, Kaye J. Williams, Amy L. Chadwick, James Bolton, Ayse Latif, Emma J Crosbie, Rhona J McVey, Ian J. Stratford

المصدر: BMC Clinical Pathology, Vol 17, Iss 1, Pp 1-10 (2017)
BMC Clinical Pathology
Latif, A, Chadwick, A L, Kitson, S J, Gregson, H J, Sivalingam, V N, Bolton, J, McVey, R J, Roberts, S A, Marshall, K M, Williams, K J, Stratford, I J & Crosbie, E J 2017, ' Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer ', BMC Clinical Pathology, vol. 17, pp. 27 . https://doi.org/10.1186/s12907-017-0067-7Test

مصطلحات موضوعية: 0301 basic medicine, Histology, Intracellular pH, Malignancy, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Endometrial cancer, medicine, lcsh:Pathology, Glycolysis, Monocarboxylate transporters, Hypoxia, biology, business.industry, medicine.disease, 3. Good health, 030104 developmental biology, Monocarboxylate transporter 1, Anaerobic glycolysis, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, Immunohistochemistry, business, Research Article, lcsh:RB1-214

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988b7c7ec7d61abc52b001e69a8d9acTest
http://link.springer.com/article/10.1186/s12907-017-0067-7Test

المؤلفون: Timothy W. Wallace, John A. Hadfield, Steven B. Rossington, Kaye J. Williams, Steven D. Shnyder

المصدر: Rossington, S, Hadfield, J, Shnyder, S D, Wallace, T & Williams, K 2017, ' Tubulin-binding dibenz[c,e]oxepines : Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents ', Bioorganic and Medicinal Chemistry, vol. 25, no. 5, pp. 1630-1642 . https://doi.org/10.1016Test/j.bmc.2017.01.027

مصطلحات موضوعية: Necrosis, Clinical Biochemistry, Pharmaceutical Science, Tumour vasculature, 01 natural sciences, Biochemistry, Tubulin binding, Structural variation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, Cell Line, Tumor, Neoplasms, Biological property, Drug Discovery, Journal Article, medicine, Animals, Humans, Colchicine, Molecular Biology, Biological evaluation, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, direct arylation, Organic Chemistry, palladium catalyst, 0104 chemical sciences, tubulin, chemistry, Cell culture, 030220 oncology & carcinogenesis, biology.protein, Heterografts, Molecular Medicine, medicine.symptom, Dibenzoxepins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7159b0428917a521e7ecb361504f199Test
https://doi.org/10.1016Test/j.bmc.2017.01.027

المؤلفون: Manal Mehibel, Fernando Ortiz-Martinez, Catharine M L West, Nadine Voelxen, Brian A. Telfer, Amy Boyers, Ian J. Stratford, Kaye J. Williams, Susan E. Critchlow, Wolfgang Mueller-Klieser, Amy L. Chadwick

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Mehibel, M, Ortiz-martinez, F, Voelxen, N, Boyers, A, Chadwick, A, Telfer, B A, Mueller-klieser, W, West, C M, Critchlow, S E, Williams, K J & Stratford, I J 2018, ' Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters ', Scientific Reports, vol. 8, no. 1, 16804 . https://doi.org/10.1038/s41598-018-35103-1Test

مصطلحات موضوعية: Monocarboxylic Acid Transporters, 0301 basic medicine, Statin, medicine.drug_class, lcsh:Medicine, Pyrimidinones, Thiophenes, Article, Oxidative Phosphorylation, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Lactic Acid, Precision Medicine, lcsh:Science, Multidisciplinary, Manchester Cancer Research Centre, biology, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, lcsh:R, Head and neck cancer, Cancer, Prognosis, medicine.disease, Head and neck squamous-cell carcinoma, 030104 developmental biology, Monocarboxylate transporter 1, Head and Neck Neoplasms, Simvastatin, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, Biomarker (medicine), lcsh:Q, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d742e81eac83a56f7780095c7b65244Test
https://doi.org/10.1038/s41598-018-35103-1Test

المؤلفون: Andrew P. Badrock, Jivko Kamarashev, Irene Barinaga-Rementeria Ramirez, Duncan Forster, Katherine A. Hollywood, Emmanuelle Claude, Adam Hurlstone, B. Ewa Snaar-Jagalska, Michael Green, Herman P. Spaink, Adam McMahon, Christos Evangelou, Hannah R Johnston, Warwick B. Dunn, Michael Fairclough, Shuning He, Fiona Henderson, Kaye J. Williams, Paul Lorigan, Michael P. Smith, Raghavendar Nagaraju, Emrys A. Jones

المصدر: Henderson, F, Johnston, H, Badrock, A, Jones, E, Forster, D, Nagaraju, R, Evangelou, C, Kamarashev, J, Green, M, Fairclough, M, Barinaga-Rementeria, I, He, S, Jagalska, E S, Hollywood, K, Dunn, W, Spaink, H P, Smith, M, Lorigan, P, Claude, E, Williams, K, Mcmahon, A & Hurlstone, A 2019, ' Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish ', Cancer Research, vol. 79, no. 9, pp. 2136-2151 . https://doi.org/10.1158/0008-5472.can-18-2409Test
Cancer Research, 79(9), 2136-2151
Cancer Research

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Phospholipid, Glycerophospholipids, Palmitic acid, Transcriptome, Mass Spectrometry Imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Manchester Institute of Biotechnology, Tumor Cells, Cultured, Animals, Humans, Metabolomics, Zebrafish, Melanoma, chemistry.chemical_classification, Lipoprotein lipase, Microphthalmia-Associated Transcription Factor, biology, Fatty Acids, Fatty acid, Lipid metabolism, Zebrafish Proteins, biology.organism_classification, Lipid Metabolism, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Fatty acid synthase, Lipoprotein Lipase, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, ras Proteins, Melanocytes, LPL, Fatty Acid Synthases, Energy Metabolism, Transcriptome Analysis, Fatty Acid

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3528b41f2ca92becf293b08a708b55Test
https://pubmed.ncbi.nlm.nih.gov/30862716Test

المؤلفون: Brian A. Telfer, Kaye J. Williams, Ian J. Stratford, BM Simoes, M Mehibel

المصدر: Cancer Research. 77:P5-07

مصطلحات موضوعية: Nitric oxide synthase, Cancer Research, Oncology, biology, Chemistry, Cancer research, biology.protein, Triple-negative breast cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c33394681fa68422b9cfc831b9f433Test
https://doi.org/10.1158/1538-7445.sabcs16-p5-07-08Test

المؤلفون: Anne White, Emma Dean, Fiona H Blackhall, M. Babur, Rachel Stovold, Suzanne Meredith, Jennifer L. Bryant, Kaye J. Williams, Caroline Dive

المصدر: British Journal of Cancer

مصطلحات موضوعية: endocrine system, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Pro-Opiomelanocortin, Transplantation, Heterologous, Immunocytochemistry, Enolase, Mice, Nude, Enzyme-Linked Immunosorbent Assay, Metastasis, Mice, Cytokeratin, Neuroendocrine Cells, medicine, metastasis, Animals, Humans, Carcinoma, Small Cell, Neoplasm Metastasis, Lung cancer, Molecular Diagnostics, biology, Liver Neoplasms, Chromogranin A, Epithelial Cells, Cadherins, Neoplastic Cells, Circulating, medicine.disease, respiratory tract diseases, Survival Rate, xenografts, Phenotype, nervous system, Oncology, biology.protein, Keratins, Immunohistochemistry, Neural cell adhesion molecule, cytokeratin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5752b353395bd16758c5f7275482caf5Test
https://doi.org/10.1038/bjc.2013.112Test

المؤلفون: Roben G. Gieling, Kaye J. Williams

المصدر: Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry; Vol 21

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Uterine Cervical Neoplasms, Pharmaceutical Science, CA 15-3, Antineoplastic Agents, Breast Neoplasms, Monoclonal antibody, Biochemistry, Metastasis, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Antigen, Antigens, Neoplasm, Drug Discovery, medicine, Animals, Humans, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Cell adhesion, Molecular Biology, Carbonic Anhydrases, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Organic Chemistry, Antibodies, Monoclonal, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Kidney Neoplasms, 3. Good health, Head and Neck Neoplasms, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Cancer cell, Immunology, Cancer research, biology.protein, Molecular Medicine, Female, Antibody

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39726575c960a63866529e2b46d1e4fTest
https://doi.org/10.1016Test/j.bmc.2012.09.062

المؤلفون: Fabrizio Carta, Jean-Yves Winum, Muhammad Babur, Natalie Burrows, Lupti Mamnani, Roben G. Gieling, Andrea Scozzafava, Claudiu T. Supuran, Kaye J. Williams, Brian A. Telfer

المساهمون: School of Pharmacy and Pharmaceutical Sciences, University of Manchester [Manchester], Laboratorio di Chimica Bioinorganica (LCBI), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry; Vol 55
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (11), pp.5591-5600. ⟨10.1021/jm300529u⟩

مصطلحات موضوعية: Gene isoform, Lung Neoplasms, Transplantation, Heterologous, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Antigens, Neoplasm, Cell Movement, Cell Line, Tumor, Carbonic anhydrase, Drug Discovery, medicine, Animals, Humans, Tumor Cell Migration, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, ComputingMilieux_MISCELLANEOUS, Carbonic Anhydrases, 030304 developmental biology, Sulfonamides, 0303 health sciences, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, Phenylurea Compounds, In vitro toxicology, medicine.disease, Primary tumor, 3. Good health, Positive response, Biochemistry, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Molecular Medicine, Female, Breast carcinoma, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5992e22d99f1f6ff1b8f5eb1a5860094Test