Cytotoxicity of 1-octyl-3-methylimidazolium chloride onEscherichia coliDH5α
| العنوان: | Cytotoxicity of 1-octyl-3-methylimidazolium chloride onEscherichia coliDH5α |
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| المؤلفون: | Xu Chen, Changqin Jing, Guo Menglong, Huanhuan Hu, Li Tianhan |
| المصدر: | Toxin Reviews. 33:91-94 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Cell division, biology, Membrane permeability, Cell growth, Succinate dehydrogenase, Toxicology, medicine.disease_cause, Medicinal chemistry, Chloride, Bacterial cell structure, Biochemistry, medicine, biology.protein, Cytotoxicity, Escherichia coli, medicine.drug |
| الوصف: | The mechanisms of the cytotoxic effect of ionic liquid (IL) 1-octyl-3-methylimidazolium chloride ([C8mim][Cl]) on bacterial cells were studied. Bacterial cells were exposed to 0, 0.1, 1 and 10 mmol ċ L−1 [C8mim][Cl] for 10 h. The results showed that [C8mim][Cl] inhibited bacterial cell proliferation in a dose-dependent manner. When IL concentrations reached 10 mmolċL−1, almost no cell division was observed. [C8mim][Cl] treatment significantly reduced succinate dehydrogenase activity. The amount of total protein significantly decreased with increasing [C8mim][Cl] concentrations of up to 10 mmolċL−1. [C8mim][Cl] increased protein and nucleic acid contents in the extracellular fluid and increased cell permeability. The results suggest that the increase in cell membrane permeability, which was induced by [C8mim][Cl], could inhibit cell proliferation and metabolic activity in bacteria. |
| تدمد: | 1556-9551 1556-9543 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a3b5848a2aa7ed08adc602cc4e448db6Test https://doi.org/10.3109/15569543.2013.867885Test |
| رقم الانضمام: | edsair.doi...........a3b5848a2aa7ed08adc602cc4e448db6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15569551 15569543 |
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