المؤلفون: Elisabeth G.E. de Vries, Christian U. Blank, John B. A. G. Haanen, Guus F. Rimmelzwaan, Egbert F. Smit, Cecile A C M van Els, Astrid A M van der Veldt, Marion Koopmans, Nynke Y. Rots, Rudolf S N Fehrmann, T. Jeroen N. Hiltermann, Mathilde Jalving, Corine H. GeurtsvanKessel, Sjoukje F. Oosting, Anke Huckriede, Pia Kvistborg, Debbie van Baarle, Valery E E P Lemmens, Anne-Marie C. Dingemans

المساهمون: Medical Oncology, Radiology & Nuclear Medicine, Pulmonary Medicine, Virology, Public Health, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR), Microbes in Health and Disease (MHD)

المصدر: Nature Medicine, 27(4), 568-569. Nature Publishing Group
Nature Medicine. Nature Publishing Group

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), biology, business.industry, MEDLINE, Cancer, General Medicine, medicine.disease, Virology, General Biochemistry, Genetics and Molecular Biology, Vaccination, Multicenter study, SDG 3 - Good Health and Well-being, biology.protein, Medicine, Antibody, Prospective cohort study, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f05c83fbac1ec5a4eb2925dda100dfTest
https://pure.eur.nl/en/publications/2b70ca55-2c99-47c8-9c5d-c1e6e0b95813Test

المؤلفون: Christian U. Blank, Daniela S. Thommen, Judith M. Versluis

المصدر: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer

مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Immunology, Context (language use), Review, Translational Research, Biomedical, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Programmed cell death 1, melanoma, medicine, Humans, Immunology and Allergy, Precision Medicine, RC254-282, Pharmacology, biology, business.industry, Melanoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunotherapy, medicine.disease, Neoadjuvant Therapy, Treatment efficacy, Cancer treatment, Human tumor, Clinical trial, 030104 developmental biology, 030220 oncology & carcinogenesis, translational medical research, biology.protein, Molecular Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe6d45de1c52a82b9d33dd6191a7069Test
https://jitc.bmj.com/content/8/2/e001352.fullTest

المؤلفون: Thijo J N Hiltermann, T. Westphal, Nynke Y. Rots, Christian U. Blank, G. den Hartog, Marion Koopmans, Mathilde Jalving, Egbert F. Smit, A.A.M. Van der Veldt, M. van der Heiden, Sjoukje F. Oosting, Anne Marie C. Dingemans, J.B.A.G. Haanen, C. A. van Els, R van Binnendijk, A. Battacharya, D. van Baarle, Rudolf S N Fehrmann, E.G.E. de Vries, Corine H. GeurtsvanKessel

المصدر: Annals of Oncology

مصطلحات موضوعية: medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, Cancer, Hematology, Immunotherapy, SARS-CoV-2 and cancer, medicine.disease, Vaccination, Clinical trial, Oncology, Internal medicine, Cohort, medicine, biology.protein, Clinical endpoint, Antibody, Adverse effect, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121cc447a79d85b059a330aa8ead3cabTest
http://europepmc.org/articles/PMC8454422Test

المؤلفون: Daniel S. Peeper, Christian U. Blank, Hans W.M. Niessen, Julia Boshuizen, Thomas Kuilman, Aida Shahrabi, Ji Ying Song, Xiangjun Kong, Kristel Kemper, Marnix H Geukes Foppen, Elisa A. Rozeman

المساهمون: CCA - Cancer biology and immunology, AGEM - Digestive immunity, ACS - Heart failure & arrhythmias, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Cardio-thoracic surgery, Pathology

المصدر: Nature, 550(7675), 270-274. Nature Publishing Group
Nature
Kong, X, Kuilman, T, Shahrabi, A, Boshuizen, J, Kemper, K, Song, J Y, Niessen, H W M, Rozeman, E A, Foppen, M H G, Blank, C U & Peeper, D S 2017, ' Cancer drug addiction is relayed by an ERK2-dependent phenotype switch ', Nature, vol. 550, no. 7675, pp. 270-274 . https://doi.org/10.1038/nature24037Test

مصطلحات موضوعية: 0301 basic medicine, Proto-Oncogene Proteins B-raf, Epithelial-Mesenchymal Transition, Lung Neoplasms, JUNB, MAP Kinase Signaling System, Dacarbazine, Antineoplastic Agents, Biology, Pharmacology, Receptor tyrosine kinase, Article, 03 medical and health sciences, Mice, Cell Line, Tumor, medicine, Animals, Humans, Epithelial–mesenchymal transition, Molecular Targeted Therapy, Melanoma, Gene Editing, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Microphthalmia-Associated Transcription Factor, Multidisciplinary, Cell Death, medicine.disease, Microphthalmia-associated transcription factor, 3. Good health, 030104 developmental biology, Phenotype, Drug Resistance, Neoplasm, Cancer cell, biology.protein, Female, CRISPR-Cas Systems, Reprogramming, medicine.drug, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df46b5ac7614ee892024f1d1e15da0caTest
https://doi.org/10.1038/nature24037Test

المؤلفون: Christian U. Blank, Saskia A C Luelmo, Marloes S. van Kester, Maarten H. Vermeer, Remco van Doorn

المصدر: JAAD Case Reports

مصطلحات موضوعية: MAPK/ERK pathway, Sorafenib, FGFR, fibroblast growth factor receptor, VEGF receptors, Case Report, Dermatology, BRAF, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, vascular endothelial growth factor receptors, Psoriasis, medicine, kinase inhibitors, VEGFR, vascular endothelial growth factor receptors, biology, EGFR, the epidermal growth factor receptor, business.industry, psoriasis, medicine.disease, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, Mitogen-activated protein kinase, biology.protein, Cancer research, sorafenib, business, MAPK, mitogen-activated protein kinase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6257b435e2cd7ccfc79bee27a5ee7bTest
http://europepmc.org/articles/PMC6250899Test

المؤلفون: Christian U. Blank, Axel Bex, Mark M. Kockx, Yasmin Abu-Ghanem, Johannes V. Van Thienen, Peter A. van Dam, Brunolf W. Lagerveld, Thomas Powles, John B. A. G. Haanen, Niels M. Graafland, Patricia J. Zondervan, Harrie P. Beerlage, Jeroen van Moorselaar, Bernadett Szabados

المصدر: Journal of Clinical Oncology. 39:4573-4573

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, medicine.disease, Nephrectomy, Axitinib, Avelumab, Vascular endothelial growth factor, chemistry.chemical_compound, chemistry, Renal cell carcinoma, Internal medicine, medicine, biology.protein, In patient, Antibody, business, Immune infiltrate, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c57d7017264ab4a32bf84b6f669e4fTest
https://doi.org/10.1200/jco.2021.39.15_suppl.4573Test

المؤلفون: Lisa Zimmer, Antje Sucker, Annette Paschen, Christian U. Blank, Vera Rebmann, J. Utikal, Elisabeth Livingstone, Rudolf A. Herbst, Peter A. Horn, Jürgen C. Becker, Kai Horny, Dirk Schadendorf, Sabine Schramm, Claudia Pföhler, Bastian Schilling, Selma Ugurel

المصدر: Annals of oncology : official journal of the European Society for Medical Oncology. 31(1)

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Metastatic melanoma, Immune checkpoint inhibitors, Treatment outcome, Programmed Cell Death 1 Receptor, Medizin, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, PD-L1, Programmed cell death 1, medicine, Biomarkers, Tumor, Effective treatment, Humans, Melanoma, Predictive biomarker, Retrospective Studies, biology, business.industry, Neoplasms, Second Primary, Hematology, medicine.disease, Prognosis, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2de829e074affe4d0a9959c449d82Test
https://pubmed.ncbi.nlm.nih.gov/33684461Test

المؤلفون: Christian U. Blank, Eliezer M. Van Allen, Derek Liu, Ricarda Rauschenberg, Keith T. Flaherty, Felix Dietlein, Levi A. Garraway, Angela M. Krackhardt, Natalie I. Vokes, Benjamin Weide, Livnat Jerby-Arnon, Jake Conway, Jochen Utikal, Helen Gogas, Dirk Schadendorf, Antje Sucker, Meng Xiao He, Haitham Elmarakeby, Carmen Loquai, Felix Kiecker, Elisabeth Livingstone, Aviv Regev, Lisa Zimmer, Dagmar von Bubnoff, Annette Paschen, Simone M. Goldinger, Adam Tracy, Bastian Schilling, David Liu, Stephan Grabbe, Sebastian Haferkamp, Ben Izar, Imke Satzger, Ralf Gutzmer, Diana Miao, Claire A. Margolis

المصدر: Nature Medicine

مصطلحات موضوعية: Oncology, Male, medicine.medical_specialty, Programmed Cell Death 1 Receptor, Medizin, Drug resistance, Antibodies, Monoclonal, Humanized, Article, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Exome Sequencing, Cancer genomics, Medicine, Humans, CTLA-4 Antigen, Neoplasm Metastasis, Author Correction, Melanoma, Exome sequencing, 030304 developmental biology, 0303 health sciences, Antigen Presentation, biology, business.industry, General Medicine, medicine.disease, ddc, 3. Good health, Blockade, Computational biology and bioinformatics, Nivolumab, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Monoclonal, Cohort, Mutation, biology.protein, Female, Antibody, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63937a6a4b4ebda7284ffda5da2b3adbTest
https://pubmed.ncbi.nlm.nih.gov/32561875Test

المؤلفون: J. Thaddeus Beck, Christian U. Blank, Angela Zubel, Adnan Derti, Heidi Nauwelaerts, Carola Berking, Victor Antona, Michael Heinrich, Dirk Schadendorf, Reinhard Dummer, Rupam Ranjan Pal, Sanjiv S. Agarwala, Rob L. H. Jansen, Carla M.L. van Herpen, Axel Hauschild, Paola Queirolo, Paolo A. Ascierto

المساهمون: MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, University of Zurich, van Herpen, Carla M L

المصدر: OncoTarget, 10(19), 1850-1859. Impact Journals LLC
Scopus-Elsevier
Oncotarget
Oncotarget, 10, 19, pp. 1850-1859
Oncotarget, 10, 1850-1859

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, Medizin, 610 Medicine & health, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, CDKN2A, medicine, melanoma, PTEN, neoplasms, MEK inhibitor, biology, business.industry, Melanoma, 10177 Dermatology Clinic, Binimetinib, phase II, medicine.disease, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, binimetinib, Cancer research, biology.protein, Biomarker (medicine), biomarker, 2730 Oncology, business, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Research Paper

وصف الملف: 798_van_Herpen_CML_et_al._Biomarker_results_from_a_phase_II_study_of_MEK_inhibitor_binimetinib_(MEK162)_in_patients_with_advanced_NRAS-_or_etc._Oncotarget_2019.pdf - application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b26652bb8787171333752b989c125a0Test
https://www.ncbi.nlm.nih.gov/pubmed/30956763Test

المؤلفون: David W. Vredevoogd, David Satijn, Marnix H Geukes Foppen, Elisa A. Rozeman, Aida Shahrabi, Jens Thing Mortensen, Thomas Kuilman, Julia Boshuizen, Christian U. Blank, Elke Gresnigt-van den Heuvel, Nora Pencheva, Oscar Krijgsman, Daniel S. Peeper, Louise A. Koopman, Esther C.W. Breij, Paul W. H. I. Parren, Kristel Kemper, Ji-Ying Song, Maarten L. Janmaat, Maarten A. Ligtenberg

المصدر: Nature Medicine, 24(2), 203

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Proto-Oncogene Proteins B-raf, Antibody-drug conjugate, Immunoconjugates, Combination therapy, Cell, General Biochemistry, Genetics and Molecular Biology, Receptor tyrosine kinase, 03 medical and health sciences, Genetic Heterogeneity, Mice, In vivo, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, Humans, Melanoma, Protein Kinase Inhibitors, biology, Chemistry, Receptor Protein-Tyrosine Kinases, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Axl Receptor Tyrosine Kinase, 030104 developmental biology, medicine.anatomical_structure, Drug Resistance, Neoplasm, biology.protein, Cancer research, Antibody, Oligopeptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff1dd468b21966ffd7a2decddea84f3Test
https://hdl.handle.net/1887/96424Test