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1
المؤلفون: David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
المصدر: Journal of Medicinal Chemistry. 64:17146-17183
مصطلحات موضوعية: Methyltransferase, Protein subunit, Allosteric regulation, macromolecular substances, Ligands, Cell Line, Structure-Activity Relationship, Allosteric Regulation, Heterocyclic Compounds, Catalytic Domain, Drug Discovery, Animals, Humans, Enhancer of Zeste Homolog 2 Protein, Enzyme Inhibitors, Enhancer, Cell Proliferation, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Small molecule, Rats, Histone methyltransferase, biology.protein, Cancer research, Molecular Medicine, PRC2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbef686d9310c0393124b8f8df7ca38Test
https://doi.org/10.1021/acs.jmedchem.1c01161Test -
2
المؤلفون: Sameer Kawatkar, Philip B. Rawlins, Kurt Gordon Pike, Jessie Hao-Ru Hsu, Shaun M. Fillery, Clare Gregson, Minhui Shen, Daniel H. O' Donovan, Martin J. Packer, Jon Read, S. Bagal, Andrew Bloecher, Beth Williamson, James Robinson, Peter Barton, Ryan Greenwood, Erin Code, Haley Woods
المصدر: Bioorganic & Medicinal Chemistry Letters. 39:127904
مصطلحات موضوعية: Methyltransferase, Protein subunit, Clinical Biochemistry, Pharmaceutical Science, Ligands, 01 natural sciences, Biochemistry, Free energy perturbation, Structure-Activity Relationship, Drug Discovery, Humans, Enzyme Inhibitors, Binding site, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Ligand, Organic Chemistry, EZH2, Polycomb Repressive Complex 2, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Purines, Drug Design, Microsomes, Liver, biology.protein, Quantum Theory, Thermodynamics, Molecular Medicine, PRC2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19eb341b997e66a555f392e58836843Test
https://doi.org/10.1016/j.bmcl.2021.127904Test -
3
المؤلفون: Beth Williamson, Patrick Barton, Paul Lancett, Robert J. Riley
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 46(8)
مصطلحات موضوعية: 0301 basic medicine, Metabolic Clearance Rate, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Drug Discovery, Potency, Distribution (pharmacology), Humans, RNA, Messenger, Glucuronosyltransferase, Cells, Cultured, biology, Chemistry, Drug discovery, Cytochrome P450, In vitro, Kinetics, 030104 developmental biology, Liver, Toxicity, biology.protein, Hepatocytes, Biological Assay
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5077201af61743cce7568418f21778Test
https://pubmed.ncbi.nlm.nih.gov/29880630Test -
4
المؤلفون: Beth Williamson, Yuan Zhang, David Back, Andrew Owen, Kelly E. Dooley
المصدر: Antimicrobial Agents and Chemotherapy. 57:6366-6369
مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Rifabutin, ATP-binding cassette transporter, Pharmacology, polycyclic compounds, medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, Cells, Cultured, biology, CYP3A4, Chemistry, Multidrug resistance-associated protein 2, Membrane Transport Proteins, Cytochrome P450, Transporter, Rifapentine, Multidrug Resistance-Associated Protein 2, Infectious Diseases, Hepatocytes, biology.protein, ABCC1, Multidrug Resistance-Associated Proteins, Rifampin, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ddcdef4883758e22beb4efcbdcce8Test
https://doi.org/10.1128/aac.01124-13Test -
5
المؤلفون: Andrew Owen, Matthew G. Soars, Robert J. Riley, A C Soars, Beth Williamson, Peter White
المصدر: Xenobiotica. 43:920-931
مصطلحات موضوعية: Male, Estrone, Health, Toxicology and Mutagenesis, Molecular Sequence Data, Organic Anion Transporters, Tetrazoles, Pharmacology, Toxicology, Biochemistry, Xenobiotics, chemistry.chemical_compound, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, RNA, Small Interfering, Rosuvastatin Calcium, Pitavastatin, Cells, Cultured, Sulfonamides, Base Sequence, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Imidazoles, Cytochrome P450, Valine, Transporter, General Medicine, Fluorobenzenes, Organic anion-transporting polypeptide, Pyrimidines, Nuclear receptor, Toxicity, Hepatocytes, Quinolines, biology.protein, Valsartan, Female, Xenobiotic, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159ba9c4f9ab41047d27d47a0d2abfc8Test
https://doi.org/10.3109/00498254.2013.776194Test