Deregulation of cell-death pathways as the cornerstone of skin diseases
| العنوان: | Deregulation of cell-death pathways as the cornerstone of skin diseases |
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| المؤلفون: | N Zutterman, Stijn Claerhout, Patrizia Agostinis, Hannelore Maes, Maria Garmyn |
| المصدر: | Clinical and Experimental Dermatology. 35:569-575 |
| بيانات النشر: | Oxford University Press (OUP), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Programmed cell death, Necrosis, integumentary system, biology, business.industry, Autophagy, Dermatology, medicine.disease, Toxic epidermal necrolysis, Apoptosis, Immunology, medicine, Cancer research, biology.protein, medicine.symptom, Skin cancer, business, Intracellular, Caspase |
| الوصف: | Deregulation of cell-death pathways plays a key role in the pathogenesis of various skin diseases. The different types of cell death are mainly defined by morphological criteria, and include apoptosis, autophagic cell death, and necrosis. The process of apoptosis is well characterized at the molecular level and involves the activation of two main pathways, the intrinsic and extrinsic pathways, converging into the execution of apoptosis by intracellular cysteine proteases, called caspases. The relevance and implication of these apoptotic pathways in the pathophysiology of skin diseases, such as toxic epidermal necrolysis, graft-versus-host disease and skin cancer, has been extensively studied. The role of autophagic cell death in progression of skin tumours and response to cytotoxic drugs is only beginning to be elucidated. |
| تدمد: | 1365-2230 0307-6938 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::060092ccd3adf802907277f173f2ab02Test https://doi.org/10.1111/j.1365-2230.2009.03614.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........060092ccd3adf802907277f173f2ab02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652230 03076938 |
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