Nod-like proteins in inflammation and disease
| العنوان: | Nod-like proteins in inflammation and disease |
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| المؤلفون: | Joao G. Magalhaes, Dana J. Philpott, Leonardo H. Travassos, Ivan Tattoli, Leticia A.M. Carneiro |
| المصدر: | The Journal of Pathology. 214:136-148 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Inflammation, Polymorphism, Genetic, Innate immune system, biology, Interleukin-1beta, NF-kappa B, NALP3, Bacterial Infections, Immunity, Innate, Pathology and Forensic Medicine, Immune system, Immunity, NOD2, Immunology, NOD1, Nod Signaling Adaptor Proteins, biology.protein, medicine, Humans, Inflammation Mediators, Signal transduction, medicine.symptom |
| الوصف: | The field of innate immunity has undergone an enormous upheaval during the last decade. The discovery of different groups of proteins, called pattern recognition molecules (PRMs), which detect microbial components, so-called pathogen-associated molecular patterns (PAMPs) and trigger protective responses, had a huge impact on the understanding of innate immune responses. Among the PRMs, the intracellular Nod-like receptors (NLRs) have recently been identified as key mediators of inflammatory and immune responses. The NLR family is divided into subfamilies on the basis of their different signal transduction domains, and recent studies have highlighted the role of certain NLRs, including Nod1, Nod2, Nalp3, Ipaf and Naip5, in the detection of intracellular microbes and possibly 'danger signals'. In this review, we summarize the current knowledge on the function of these proteins in immunity and inflammation, with a focus on their participation in different disease pathologies. |
| تدمد: | 1096-9896 0022-3417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0336fb7d906d32ac0884537d5176486Test https://doi.org/10.1002/path.2271Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0336fb7d906d32ac0884537d5176486 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969896 00223417 |
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