نتائج البحث - "Histone Deacetylases--metabolism"

المساهمون: School of Pharmaceutical Sciences, Université de Lausanne (UNIL)-University of Geneva [Switzerland], Réseau épigénétique, Cancéropôle Grand-Ouest, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institute of Enzymology [Budapest], Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Authors thank the Centre National de la Recherche Scientifique– France, University of Poitiers, Region Poitou-Charentes (S.B. financial support), the Ligue Contre le Cancer: Committees of Vendée, et Charente-Maritime – France, ARSMeso44 – France, COST Actions CM1406 and CM1106 – Belgium and Hungarian OTKA Founds K-101039 and K-112144 for financial support. A.N. thanks the Excellence programme of the University of Geneva –Switzerland for financial support., Bernardo, Elizabeth, Université de Lausanne = University of Lausanne (UNIL)-Université de Genève = University of Geneva (UNIGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS)

المصدر: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic and Medicinal Chemistry Letters, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 1 (2016) pp. 154-159

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Intrinsic activity, Formic Acid Esters, Stereochemistry, Clinical Biochemistry, Convergent synthesis, Pharmaceutical Science, [SDV.CAN]Life Sciences [q-bio]/Cancer, Alkenes, Hydroxamic Acids, Metathesis, Biochemistry, Histone Deacetylases, Catalysis, Dose-Response Relationship, Formic Acid Esters/chemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, [SDV.CAN] Life Sciences [q-bio]/Cancer, Models, Drug Discovery, Humans, Structure–activity relationship, Benzamides/chemistry, Benzamide, Molecular Biology, ddc:615, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, Molecular, Alkenes/chemistry, 3. Good health, Histone Deacetylase Inhibitors, 030104 developmental biology, Tubulin, Histone Deacetylase Inhibitors/chemistry/pharmacology, Hydroxamic Acids/chemistry, chemistry, Benzamides, biology.protein, Molecular Medicine, Histone Deacetylases/metabolism, Drug, Selectivity

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc9fefa73c13b45a09cef22d951db0cTest
https://www.hal.inserm.fr/inserm-01299475/documentTest

5

‘Relax and Repair’ to restrain aging

المؤلفون: Krishnan, Zhongjun Zhou, Baohua Liu

المصدر: Aging (Albany NY)

مصطلحات موضوعية: Premature aging, Aging - genetics, Aging, DNA Repair, Nuclear Proteins - chemistry - genetics - metabolism, DNA repair, Histone Acetylation, Senescence, Histone Deacetylases, Chromatin remodeling, Epigenesis, Genetic, Histones, Histone H4, Mice, Progeria, Prelamin A, Premature Aging, Humans, Animals, Histone code, Zmpste24, Protein Precursors, Lamin Type A - chemistry - genetics - metabolism, Hgps, Genetics, biology, Nuclear Proteins, Cell Biology, Lamin Type A, Histone Deacetylases - metabolism, Chromatin, Cell biology, Histone, Progeria - genetics - physiopathology, Research Perspective, Lamin A, Chromatin - chemistry - metabolism, biology.protein, Histones - metabolism, Epigenetics, DNA mismatch repair, Protein Precursors - chemistry - genetics - metabolism, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c47b742530234e85caa09b5d3770e13Test
https://doi.org/10.18632/aging.100399Test

6

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

المؤلفون: Michelandrea De Cesare, Muriel Cuendet, Sabrina Dallavalle, Vincent Zwick, Giuseppe Giannini, Alessandra Nurisso, Raffaella Cincinelli, Valentina Zuco, Loana Musso, Franco Zunino, Claudia A. Simões-Pires

المصدر: European Journal of Medicinal Chemistry, Vol. 112 (2016) pp. 99-105

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Antineoplastic Agents, Apoptosis, Drug Screening Assays, Hydroxamic Acids, Histone Deacetylases, Histone H4, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Neoplasms, Drug Discovery, Structure–activity relationship, Humans, Biphenyl Compounds/chemistry/pharmacology, Pharmacology, ddc:615, Neoplasms/drug therapy/metabolism, biology, Colonic Neoplasms/drug therapy/metabolism, Apoptosis/drug effects, Organic Chemistry, Biphenyl Compounds, Active site, Antitumor, General Medicine, HCT116 Cells, In vitro, Hydroxamic Acids/chemistry/pharmacology, Biphenyl compound, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Histone Deacetylase Inhibitors/chemistry/pharmacology, chemistry, Biochemistry, Acetylation, Colonic Neoplasms, biology.protein, Histone Deacetylases/metabolism, Antineoplastic Agents/chemistry/pharmacology, Drug Screening Assays, Antitumor, Derivative (chemistry)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c41240a5dcd709036f451727b80a3b2Test
https://pubmed.ncbi.nlm.nih.gov/26890116Test

7

Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model

المؤلفون: Mathieu Boxus, Julie Lodewick, Françoise Bex, Carla Sampaio, Lucas Willems, Anne-Sophie Rinaldi, Pierre P. Roger, Katia Coulonval

المصدر: Retrovirology, 10
Retrovirology

مصطلحات موضوعية: Gene Products, tax -- metabolism, CDK4, Fibroblasts -- virology, Human T-lymphotropic virus 1 -- pathogenicity, Lysine -- metabolism, Tax, SUMO protein, P300-CBP Transcription Factors, Histone Deacetylases, p300-CBP Transcription Factors -- metabolism, Transformation, Cell Line, Ubiquitin, Virology, Animals, Humans, p300-CBP Transcription Factors, Kinase activity, Human T-lymphotropic virus 1, Histone deacetylase 5, Leukemia, biology, Physiologie de la régulation, Research, Lysine, Retinoblastoma protein, Virologie médicale, Acetylation, Gene Products, tax, Fibroblasts, Sciences bio-médicales et agricoles, Cell Transformation, Viral, Cell biology, Rats, Infectious Diseases, HTLV-1, Immunology, biology.protein, Phosphorylation, Histone Deacetylases -- metabolism, Protein Processing, Post-Translational

وصف الملف: 1 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee701f71482c8e8e3732ac7a311293eTest
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/149587Test

8

The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G(1) is controlled by a deacetylase- and E2F-associated bipartite repressor element

المؤلفون: Didier Trouche, Raphael Herrera, Claude Sardet, Stéphane Emiliani, Laurent Le Cam, Jolanta Polanowska, Eric Fabbrizio

المساهمون: NXP Semiconductors, Laboratoire de biologie moléculaire eucaryote (LBME), Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: Oncogene
Oncogene, Nature Publishing Group, 2001, 20 (31), pp.4115--27. ⟨10.1038/sj.onc.1204514⟩

مصطلحات موضوعية: Cancer Research, Cyclin E, Cyclin D, Cyclin A, Molecular Sequence Data, Repressor, Down-Regulation, Mitosis, Cell Cycle Proteins, Chromatography, Affinity, Histone Deacetylases, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, E2F, Promoter Regions, Genetic, Molecular Biology, 030304 developmental biology, Affinity Cyclin E/*genetics Dna *DNA-Binding Proteins *Down-Regulation E2F Transcription Factors Histone Deacetylases/metabolism Humans K562 Cells Mitosis/*genetics Molecular Sequence Data Promoter Regions (Genetics) Repressor Proteins/isolation & purification/metabolism Transcription Factors/metabolism, 0303 health sciences, biology, Cell Cycle, DNA, Cell cycle, Molecular biology, Cell biology, E2F Transcription Factors, DNA-Binding Proteins, Repressor Proteins, 030220 oncology & carcinogenesis, biology.protein, Histone deacetylase activity, biological phenomena, cell phenomena, and immunity, Carrier Proteins Cell Cycle *Cell Cycle Proteins Chromatography, Carrier Proteins, K562 Cells, Cyclin A2, Retinoblastoma-Binding Protein 1, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c83622b8f0535894356764bf2a4b6dTest
https://pubmed.ncbi.nlm.nih.gov/11464278Test

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