يعرض 1 - 10 نتائج من 268 نتيجة بحث عن '"proprotein convertase 9"', وقت الاستعلام: 1.38s تنقيح النتائج
  1. 1
    Serum Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is Independently Associated with Insulin Resistance, Triglycerides, Lipoprotein(a) Levels but not Low-Density Lipoprotein Cholesterol Levels in a General Population

    المؤلفون: Mika Enomoto, Kenta Toyomasu, Ako Fukami, Sachiko Nakamura, Yume Nohara, Akiko Sakaue, Hitoshi Hamamura, Nagisa Morikawa, Yoshihiro Fukumoto, Hisashi Adachi, Maki Yamamoto

    المصدر: Journal of Atherosclerosis and Thrombosis

    مصطلحات موضوعية: Male, medicine.medical_specialty, Epidemiology, Population, 030204 cardiovascular system & hematology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Japan, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Correlation of Data, Medical History Taking, education, Triglycerides, Aged, Alirocumab, education.field_of_study, biology, business.industry, PCSK9, Biochemistry (medical), Blood Pressure Determination, Cholesterol, LDL, Lipoprotein(a), medicine.disease, Proprotein convertase subtilisin/kexin type 9 (PCSK9), Evolocumab, Endocrinology, Population Surveillance, biology.protein, Kexin, Female, Original Article, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Lipoprotein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de4e7d54d1bb5478f407dcf3bdcfeabTest
    https://doi.org/10.5551/jat.56390Test


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  2. 2
    PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36

    المؤلفون: Wenlong Yang, Xin Liu, Zhongren Ding, Aijun Sun, Haoxuan Zhong, Zhifeng Yao, Liang Hu, Juying Qian, Kang Yao, Jianjun Zhang, Lin Chang, Junbo Ge, Zhiyong Qi, Daile Jia, Guanxing Pan, Xinping Luo

    المصدر: Circulation. 143:45-61

    مصطلحات موضوعية: Blood Platelets, CD36 Antigens, medicine.medical_specialty, Platelet Aggregation, CD36, Myocardial Infarction, 030204 cardiovascular system & hematology, Mice, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Animals, Humans, Medicine, Platelet, Platelet activation, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Aspirin, biology, business.industry, PCSK9, PCSK9 Inhibitors, Subtilisin, Thrombosis, Platelet Activation, Proprotein convertase, Mice, Inbred C57BL, Evolocumab, Endocrinology, biology.protein, Kexin, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021bf23422ec83a595758a37bec4850bTest
    https://doi.org/10.1161/circulationaha.120.046290Test


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  3. 3
    Plasma kinetics of mature PCSK9, furin-cleaved PCSK9, and Lp(a) with or without administration of PCSK9 inhibitors in acute myocardial infarction

    المؤلفون: Yuta Kagaya, Eiji Nozaki, Masateru Kondo, Masanori Kanazawa, Kenjiro Sato, Hideaki Endo, Akihiro Nakamura

    المصدر: Journal of Cardiology. 76:395-401

    مصطلحات موضوعية: Male, medicine.medical_specialty, Myocardial Infarction, 030204 cardiovascular system & hematology, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Aged, Furin, biology, business.industry, Anticholesteremic Agents, PCSK9, PCSK9 Inhibitors, Area under the curve, Lipoprotein(a), Middle Aged, medicine.disease, Evolocumab, Endocrinology, biology.protein, Cardiology, Kexin, Female, Proprotein Convertase 9, Antibody, Cardiology and Cardiovascular Medicine, business, Lipoprotein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe054c402d8a8b59d7bd99ac49e1166aTest
    https://doi.org/10.1016/j.jjcc.2020.04.006Test


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  4. 4
    Endothelial-Specific Overexpression of Histone Deacetylase 2 Protects Mice against Endothelial Dysfunction and Atherosclerosis

    المؤلفون: Anil Bhatta, Kei Akiyoshi, Yohei Nomura, Mingming Han, Daijiro Hori, Ke Chen, Mitsunori Nakano, Deepesh Pandey

    المصدر: Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 947-958 (2020)

    مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Vasodilator Agents, Histone Deacetylase 2, Mice, Transgenic, Vasodilation, Pulse Wave Analysis, Nitric Oxide, lcsh:Physiology, Nitric oxide, lcsh:Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Apolipoproteins E, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Oil Red O, lcsh:QD415-436, Endothelium, Endothelial dysfunction, Aorta, lcsh:QP1-981, biology, Histone deacetylase 2, Endothelial Cells, Atherosclerosis, medicine.disease, Plaque, Atherosclerotic, Lipoproteins, LDL, Mice, Inbred C57BL, Nitric oxide synthase, HEK293 Cells, 030104 developmental biology, Endocrinology, chemistry, 030220 oncology & carcinogenesis, biology.protein, Endothelium, Vascular, Sodium nitroprusside, Proprotein Convertase 9, medicine.drug, Lipoprotein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43aba4520a6be4db01d2ba2744e7fb1Test
    https://doi.org/10.33594/000000280Test


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  5. 5
    Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a)

    المؤلفون: Renate M. Hoogeveen, Simone L. Verweij, Jeffrey Kroon, Johan G. Schnitzler, Arjen J. Cupido, Mahnoush Bahjat, Lotte C.A. Stiekema, Erik S.G. Stroes, Sotirios Tsimikas, Kim E. Dzobo, Koen H.M. Prange, Menno P.J. de Winther

    المساهمون: Graduate School, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Medical Biochemistry, Experimental Vascular Medicine, ACS - Microcirculation, AII - Inflammatory diseases, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

    المصدر: European heart journal, vol 41, iss 24
    European heart journal, 41(24), 2262-2271. Oxford University Press

    مصطلحات موضوعية: medicine.medical_specialty, Apolipoprotein B, Clinical Sciences, Oligonucleotides, Inflammation, Cardiorespiratory Medicine and Haematology, 030204 cardiovascular system & hematology, PCSK9ab, Cardiovascular, Apoprotein(a), Monocytes, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Apo(a)-antisense, Gene expression, medicine, Humans, 030212 general & internal medicine, Transcriptomics, biology, business.industry, Lipoprotein(a), Atherosclerosis, Heart Disease, Endocrinology, Cardiovascular System & Hematology, biology.protein, Kexin, Proprotein Convertase 9, medicine.symptom, Antibody, Cardiology and Cardiovascular Medicine, business, Ex vivo, Lipoprotein

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06540fe5347f3b6185d5d7a2106715dTest
    http://www.scopus.com/inward/record.url?scp=85088536364&partnerID=8YFLogxKTest


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  6. 6
    Low-density lipoprotein cholesterol lowering treatment: the current approach

    المؤلفون: Ana Maria Alexandra Stănescu, Nicolae Bacalbasa, Camelia Cristina Diaconu, Ovidiu Gabriel Bratu, Anca Pantea Stoian, Mihnea-Alexandru Găman, Irina Crismaru

    المصدر: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-10 (2020)
    Lipids in Health and Disease

    مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Gene Expression, Review, 030204 cardiovascular system & hematology, Bioinformatics, Microsomal triglyceride transfer protein, 0302 clinical medicine, Endocrinology, LDL-cholesterol, Dicarboxylic Acids, 030212 general & internal medicine, RNA, Small Interfering, lcsh:RC620-627, media_common, biology, Anticholesteremic Agents, Fatty Acids, Europe, lcsh:Nutritional diseases. Deficiency diseases, PCSK9 inhibitors, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, medicine.drug, Drug, Statin, Clinical chemistry, medicine.drug_class, media_common.quotation_subject, Hypercholesterolemia, Guidelines as Topic, Clinical nutrition, Antibodies, Monoclonal, Humanized, Bile Acids and Salts, 03 medical and health sciences, Ezetimibe, medicine, Humans, business.industry, PCSK9, Biochemistry (medical), Statins, Cholesterol, LDL, medicine.disease, Atherosclerosis, Dyslipidemia, biology.protein, Benzimidazoles, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Carrier Proteins, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5c90f769f900aa681ce65a48241d47Test
    http://link.springer.com/article/10.1186/s12944-020-01275-xTest


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  7. 7
    Discordant responses of plasma low-density lipoprotein cholesterol and lipoprotein(a) to alirocumab: A pooled analysis from 10 ODYSSEY Phase 3 studies

    المؤلفون: Matthew K. Ito, Sergio Fazio, Andrew Koren, Jessica Minnier, Michael D. Shapiro, Ivy W. Kam, Tahir Mahmood, Qian H Li

    المصدر: European Journal of Preventive Cardiology. 28:816-822

    مصطلحات موضوعية: Male, medicine.medical_specialty, Epidemiology, Low density lipoprotein cholesterol, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Randomized Controlled Trials as Topic, Alirocumab, biology, business.industry, Anticholesteremic Agents, PCSK9, PCSK9 Inhibitors, Subtilisin, Cholesterol, LDL, Lipoprotein(a), Middle Aged, medicine.disease, Treatment Outcome, Endocrinology, Clinical Trials, Phase III as Topic, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, business, Lipoprotein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774dc03165e7045d563e040023d20a01Test
    https://doi.org/10.1177/2047487320915803Test


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  8. 8
    The benign c.344G > A: p.(Arg115His) variant in the LDLR gene interpreted from a pedigree-based genetic analysis of familial hypercholesterolemia

    المؤلفون: Mariko Harada-Shiba, Atsushi Takahashi, Cheol Son, Masatsune Ogura, Mika Hori

    المصدر: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-5 (2020)
    Lipids in Health and Disease

    مصطلحات موضوعية: 0301 basic medicine, Male, Apolipoprotein B, Endocrinology, Diabetes and Metabolism, Annotation, Clinical Biochemistry, Familial hypercholesterolemia, Short Report, 030204 cardiovascular system & hematology, Genetic analysis, Polymorphism, Single Nucleotide, Hyperlipoproteinemia Type II, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, medicine, Humans, Family, Genetic Predisposition to Disease, Variant, Gene, Allele frequency, lcsh:RC620-627, Genetics, biology, PCSK9, Biochemistry (medical), nutritional and metabolic diseases, LDL receptor, Middle Aged, medicine.disease, Pedigree, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, Receptors, LDL, Benign, biology.protein, Kexin, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9621370bafd29602be542c44726453bfTest
    http://link.springer.com/article/10.1186/s12944-020-01252-4Test


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  9. 9
    IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease

    المؤلفون: Hui-Kim Yap, Liangjian Lu, Henry H Yang, Lauretta D Low, Chang-Yien Chan, Caroline G.L. Lee, Kar-Hui Ng, Hanry Yu, Jinmiao Chen

    المصدر: Clinical Science. 134:225-237

    مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Lipoproteins, Hypercholesterolemia, 030232 urology & nephrology, Down-Regulation, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Animals, ATP Binding Cassette Transporter, Subfamily G, Member 5, Rats, Wistar, Liver X Receptors, Sterol Regulatory Element Binding Proteins, Interleukin-13, biology, Cholesterol, Nephrosis, Lipoid, PCSK9, Hypertriglyceridemia, nutritional and metabolic diseases, Liver X receptor alpha, General Medicine, medicine.disease, Disease Models, Animal, Proteinuria, 030104 developmental biology, Endocrinology, Liver, chemistry, LDL receptor, ABCG5, biology.protein, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Steatosis

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e350a638d49dac0da966d8de98013fTest
    https://doi.org/10.1042/cs20190961Test


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  10. 10
    No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice

    المؤلفون: André Rex, Vincent Prinz, Hans M.G. Princen, Paul Fischer, Matthias Endres, Frieder Schlunk, Dieter Lütjohann, Ulrich Laufs, Marco Foddis

    المصدر: Behavioural brain research 396, 112875-(2021). doi:10.1016/j.bbr.2020.112875
    Behavioral Brain Research, 396

    مصطلحات موضوعية: Apolipoprotein E, Morris water navigation task, Biomedical Innovation, Open field, Behavioral Neuroscience, chemistry.chemical_compound, Mice, 0302 clinical medicine, Life, drug effects [Behavior, Animal], 0303 health sciences, Behavior, Animal, biology, PCSK9 Inhibitors, Cholesterol, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Antibody, MHR - Metabolic Health Research, pharmacology [Protease Inhibitors], drug effects [Recognition, Psychology], Healthy Living, Locomotion, medicine.medical_specialty, Side effect, Spatial Learning, Antibodies, 03 medical and health sciences, drug effects [Locomotion], Internal medicine, medicine, Animals, Protease Inhibitors, Behaviour, ddc:610, immunology [Proprotein Convertase 9], PCSK9-inhibitors, 030304 developmental biology, business.industry, PCSK9, drug effects [Spatial Learning], Cognitition, Recognition, Psychology, Animal research, Endocrinology, chemistry, biology.protein, ELSS - Earth, Life and Social Sciences, business, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f54470c79c01128abda419148f08aTest


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