المؤلفون: Aracelys López-Castilla, Benjamin Bardiaux, Nadia Izadi-Pruneyre, Olivera Francetic, Florence Cordier, Régine Dazzoni, Michael Nilges

المساهمون: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Plateforme technologique de RMN biologique - Biological NMR Technological Platform, Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions, This work was funded by the Institut Pasteur, the Centre National de la Recherche Scientifique (CNRS), the French Agence Nationale de la Recherche (ANR Synergy-T2SS ANR-19-CE11-0020-01), the Fondation pour la Recherche Médicale (Equipe FRM 2017M.DEQ20170839114)., We thank Rémy Le Meur and Bruno Vitorge for their help in NMR experiments., ANR-19-CE11-0020,SYNERGY_T2SS,Structure et fonction moléculaire du pseudopilus dans la sécrétion de protéines par lla voiè de type 2(2019), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plateforme Technologique de RMN Biologique et HDX-MS - Biological NMR and HDX-MS Technological Platform

المصدر: Biomolecular NMR Assignments
Biomolecular NMR Assignments, Springer, 2021, 15 (2), ⟨10.1007/s12104-021-10045-4⟩
Biomolecular NMR Assignments, 2021, 15 (2), ⟨10.1007/s12104-021-10045-4⟩

مصطلحات موضوعية: 0303 health sciences, Inner membrane complex, biology, Type II secretion system, Chemistry, [SDV]Life Sciences [q-bio], C-terminus, 030302 biochemistry & molecular biology, Klebsiella oxytoca, Periplasmic space, biology.organism_classification, NMR resonance assignment, Biochemistry, 03 medical and health sciences, Structural Biology, Cytoplasm, PulL, Biophysics, Secretion, Protein secondary structure, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6684ff74512edc70e4386ef6bf9adf45Test
https://doi.org/10.1007/s12104-021-10045-4Test

المؤلفون: Nadia Izadi-Pruneyre, Benjamin Bardiaux, Theis Jacobsen, Olivera Francetic, Michael Nilges

المساهمون: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), ED 515 - Complexité du vivant, Sorbonne Université (SU), Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions, This work was funded by the French Agence Nationale de la Recherche (ANR-14-CE09-0004 to OF), the INCEPTION project (PIA/ANR-16-CONV-0005), the FRM (Equipe FRM 2017 M.DEQ 20170839114 to MN) and the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant agreement 765042., We are grateful to the Institut Pasteur and the CNRS for their continued support for our research., ANR-14-CE09-0004,FiberSpace,Pili de type IV et pseudopili: structure, dynamique, assemblage et fonction moléculaire(2014), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 765042,H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers ,ViBrANT(2018), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Medical Microbiology and Immunology
Medical Microbiology and Immunology, Springer Verlag, 2019, ⟨10.1007/s00430-019-00642-5⟩
Medical Microbiology and Immunology, 2019, ⟨10.1007/s00430-019-00642-5⟩

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Minor pilins, Models, Molecular, Protein Conformation, Protein subunit, 030106 microbiology, Immunology, Virulence, Review, medicine.disease_cause, Pilus, Bacterial Adhesion, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, medicine, Type IV pili, Immunology and Allergy, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Type II secretion system, biology, Host Microbial Interactions, Neisseria meningitidis, Pathogenic bacteria, General Medicine, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 030104 developmental biology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, chemistry, Fimbriae, Bacterial, Adhesion, bacteria, Fimbriae Proteins, Protein Multimerization, Bacteria, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edca80a29f8fabc87284d8c52a141849Test
http://europepmc.org/articles/PMC7248040Test

المؤلفون: Hamed Khakzad, Guy Tran Van Nhieu, Yasaman Karami, Lars Malmstroem, Michael Nilges, Johan Malmström, Lotta Happonen

مصطلحات موضوعية: biology, Host-pathogen interactions, Chemistry, Phagocytosis, M1 protein, Virulence, Human pathogen, biology.organism_classification, medicine.disease_cause, Molecular dynamic simulations, Epitope, Cell biology, Structural biology, Integrative structural biology, Streptococcus pyogenes, medicine, biology.protein, Bacteria, Cross-linking mass spectrometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb3c33fb93281eecd4558b60e1a0ec3Test

المؤلفون: Imen Bassoumi-Jamoussi, Guillaume Bouvier, Michael Nilges, Mourad Barhoumi, N. Kyle Tanner, Josette Banroques, Arnaud Blondel, Ikram Guizani, Nathan Desdouits, Khadija Essafi-Benkhadir, Hélène Munier-Lehmann, Emna Harigua-Souiai, Yosser Zina Abdelkrim, Ons Zakraoui

المساهمون: Laboratoire d'Epidémiologie Moléculaire et de Pathologie Expérimentale Appliquée aux Maladies Infectieuses (LR11IPT04), Université Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Bioinformatique structurale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Expression Génétique Microbienne (EGM (UMR_8261 / FRE_3630)), Institut de biologie physico-chimique (IBPC), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences de Bizerte, Université de Carthage - University of Carthage, Chimie et Biocatalyse, This work received financial support from the Institut Pasteur PTR program (grant PTR426), and partially from the Ministry of Higher Education and Research in Tunisia (LR00IPT04 & LR11IPT04, IG), MN received financial support from the Investissement d’Avenir bioinformatics programme (Grant Bip:Bip ANR-BINF-03-01) and BayCellS FP7-IDEAS-ERC 294809, NKT and JB are supported by a Centre National de la Recherche Scientifique (CNRS), HeliDEAD grant [ANR-13- BSV8-0009-01] from the Agence Nationale de la Recherche and the Initiative d’Excellence program from the French State [DYNAMO, ANR-11-LABX-0011-01]. EHS received support from the UNESCO-L’Oréal 'For Women in Science' international fellowship and the Institut Pasteur International Network (Calmette and Yersin programme). The non commercial compounds were obtained from Dr. Laïla El Kihel from Université de Caen de Basse-Normandie, Centre d’Études et de Recherche sur le Médicament de Normandie (CERMN), UFR des Sciences Pharmaceutiques, for the minimal costs of shipping fees. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, ANR-10-BINF-03-01/10-BINF-0003,Bip:Bip,Bip:Bip(2010), ANR-13-BSV8-0009,HeliDEAD,Les ARN hélicases à boite DEAD: quels sont leurs rôles, leurs partenaires, leurs substrats ARN et comment elles fonctionnent.(2013), ANR-11-LABX-0011/11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), European Project: 294809,EC:FP7:ERC,ERC-2011-ADG_20110310,BAYCELLS(2012), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie physico-chimique (IBPC (FR_550)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences de Bizerte [Université de Carthage], ANR-10-BINF-0003,Bip:Bip,Paradigme d'inference bayesienne pour la Biologie structurale in silico(2010), ANR-11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]

المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Life Cycles, [SDV]Life Sciences [q-bio], Drug Evaluation, Preclinical, Protozoology, MESH: Parasitic Sensitivity Tests, Biochemistry, Chemical library, MESH: Eukaryotic Initiation Factor-4A, Database and Informatics Methods, White Blood Cells, chemistry.chemical_compound, Parasitic Sensitivity Tests, Animal Cells, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Leishmania infantum, MESH: Inhibitory Concentration 50, Protozoans, Leishmania, Adenosine Triphosphatases, biology, Chemistry, lcsh:Public aspects of medicine, Eukaryota, Adenosine triphosphatase, Parasitic diseases, MESH: Leishmania infantum, Enzymes, 3. Good health, Molecular Docking Simulation, Infectious Diseases, Helicases, MESH: Drug Evaluation, Preclinical, Protozoan Life Cycles, Cellular Types, Sequence Analysis, MESH: Models, Molecular, Research Article, Amastigotes, lcsh:Arctic medicine. Tropical medicine, Bioinformatics, lcsh:RC955-962, Immune Cells, Immunology, Antiprotozoal Agents, Research and Analysis Methods, Microbiology, Inhibitory Concentration 50, 03 medical and health sciences, Eukaryotic translation, MESH: Adenosine Triphosphatases, MESH: Molecular Docking Simulation, Initiation factor, Binding site, MESH: Antiprotozoal Agents, Amastigote, Virtual screening, Blood Cells, Binding Sites, Promastigotes, Macrophages, Phosphatases, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Proteins, lcsh:RA1-1270, Cell Biology, biology.organism_classification, RNA helicases, Parasitic Protozoans, 030104 developmental biology, MESH: Binding Sites, Sequence motif analysis, Eukaryotic Initiation Factor-4A, Enzymology, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0672f598131f3a814de19e5a2c66f228Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424Test

المؤلفون: Dung Le-Nguyen, Jean-Christophe Barale, Christophe Nguyen, Michael Nilges, Giacomo Bastianelli, Anthony Bouillon

المساهمون: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunologie moléculaire des parasites, Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), This work was partly supported by MEST-CT-05-020311, a Marie Curie Early Stage Research Training Fellowship (EIMID) of the Framework Program 6 by the European Commission. AB is a fellow of the ‘‘Direction Generale pour l’Armement’’ from the French Ministry of Defense. This work was partly supported by the ‘‘Fond de ́die ́: combattre les maladies parasitaires’’ granted by Sanofi-Aventis and the French Ministry of Research and the Institut Carnot-Pasteur Maladies Infectieuses. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SYSDIAG, CNRS UMR3145 CNRS-BioRad provided support in the form of salaries and operating costs for authors CN and DLN, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘‘author contributions’’ section., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩
PLoS ONE, Vol 9, Iss 10, p e109269 (2014)
PLoS ONE, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩

مصطلحات موضوعية: Plasmodium, Protein Conformation, MESH: Sequence Homology, Amino Acid, medicine.medical_treatment, Plasmodium vivax, MESH: Subtilisins/genetics, Protozoan Proteins, lcsh:Medicine, Protein Synthesis, Bioinformatics, Crystallography, X-Ray, Biochemistry, MESH: Protozoan Proteins/chemistry, 0302 clinical medicine, Protein structure, MESH: Protein Conformation, Biochemical Simulations, Plasmodium Vivax, Subtilisins, Enzyme Inhibitors, lcsh:Science, Protein Synthesis Inhibitors, Protozoans, 0303 health sciences, Multidisciplinary, Malarial Parasites, Proteases, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Enzyme structure, 3. Good health, Enzymes, Molecular Docking Simulation, Plasmodium Falciparum, Protein Binding, Research Article, Trypsin inhibitor, MESH: Protozoan Proteins/genetics, Computational biology, Biology, MESH: Plasmodium vivax/chemistry, MESH: Subtilisins/chemistry, Protein Chemistry, Catalysis, 03 medical and health sciences, Chemical Biology, Parasite Groups, medicine, Malaria, Vivax, MESH: Molecular Docking Simulation, Humans, MESH: Protein Binding, Protease Inhibitors, Homology modeling, 030304 developmental biology, Protease, MESH: Humans, Sequence Homology, Amino Acid, lcsh:R, Subtilisin, Organisms, Biology and Life Sciences, Proteins, Computational Biology, MESH: Plasmodium vivax/metabolism, biology.organism_classification, MESH: Catalysis, MESH: Crystallography, X-Ray, Biochemical Activity, Parasitic Protozoans, Serine Protease Inhibitors, Docking (molecular), MESH: Malaria, Vivax/metabolism, Enzymology, lcsh:Q, Parasitology, Proteinase Inhibitors, Serine Proteases, Peptides, Apicomplexa, MESH: Malaria, Vivax/pathology, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db9f16ade63ba8d5025b234e8dd8765Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01414431/documentTest

المؤلفون: Agathe Subtil, Alice Dautry-Varsat, Cédric Delevoye, Michael Nilges

المصدر: Journal of Biological Chemistry. 279:46896-46906

مصطلحات موضوعية: 0303 health sciences, 030306 microbiology, Endoplasmic reticulum, Lipid bilayer fusion, Cell Biology, Biology, medicine.disease_cause, biology.organism_classification, Biochemistry, Microbiology, Cell biology, 03 medical and health sciences, Protein structure, Cytoplasm, medicine, Chlamydiaceae, Heterologous expression, Chlamydia trachomatis, Molecular Biology, Peptide sequence, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::96310f3b018e20502f2e86490f8f695fTest
https://doi.org/10.1074/jbc.m407227200Test

المؤلفون: Thérèse E. Malliavin, Michael Nilges, Luca Maragliano, Isidro Cortes Ciriano, Guillaume Bouvier

المصدر: ResearcherID

مصطلحات موضوعية: Bordetella pertussis, biology, Calmodulin, Stereochemistry, Chemistry, Hydrogen bond, Biophysics, cyaA, biology.organism_classification, Cyclase, Catalysis, Molecular dynamics, Crystallography, Domain (ring theory), biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28294e7f02e5b7a026a8a1e54187923aTest

المؤلفون: Michael Nilges, Helena Kovacs, Matthew Lord, Iain D. Campbell, Michael D. Yudkin, David Comfort

المصدر: Journal of Biomolecular NMR. 19:293-304

مصطلحات موضوعية: inorganic chemicals, biology, Chemistry, Protein dynamics, Bacillus subtilis, biology.organism_classification, Biochemistry, Microbiology, Protein structure, Sigma factor, Phosphorylation, Binding site, Transcription factor, Spectroscopy, Function (biology)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7e986ddefb63a92a3492d8254ba82e6Test
https://doi.org/10.1023/a:1011247523112Test

المؤلفون: Michael Nilges, Elena Baraldi, Michael Sattler, Niklas Blomberg, Matti Saraste

المصدر: Structure. 8:1079-1087

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Static Electricity, Muscle Proteins, Genome, Protein Structure, Secondary, chemistry.chemical_compound, Structural Biology, Animals, Inositol, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, Binding Sites, biology, Blood Proteins, Helminth Proteins, Phosphoproteins, Electrostatics, biology.organism_classification, Recombinant Proteins, Protein Structure, Tertiary, Pleckstrin homology domain, Membrane, chemistry, Heteronuclear molecule, Biochemistry, Biophysics, Signal transduction, Sequence Alignment, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0390a1e04613e64a6986e5812df36aTest
https://doi.org/10.1016/s0969-2126Test(00)00509-8

المؤلفون: MacDonald J. Christie, Merlin E.H. Howden, Jamie I. Fletcher, Ross Smith, Mark Connor, Michael Nilges, Seán I. O'Donoghue, Glenn F. King

المصدر: Nature Structural Biology. 4:559-566

مصطلحات موضوعية: Models, Molecular, Insecta, Magnetic Resonance Spectroscopy, Australian funnel-web spider, Protein Conformation, Stereochemistry, Molecular Sequence Data, Neurotoxins, Spider Venoms, Venom, Sulfides, Biochemistry, Neuroblastoma, Protein structure, Structural Biology, Tumor Cells, Cultured, Genetics, Animals, Periplaneta, Amino Acid Sequence, Cysteine, Mammals, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, biology, Chemistry, Calcium channel, Cystine knot, Australia, Glioma, Calcium Channel Blockers, biology.organism_classification, Omega-Conotoxins, Hadronyche versuta, Rats, Electrophysiology, Inhibitor cystine knot, Ion Channel Gating

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d78a5499fde42f761031188250aee5bTest
https://doi.org/10.1038/nsb0797-559Test