التفاصيل البيبلوغرافية
| العنوان: |
Noninvasive Mechanical Ventilation Improves Breathing-Swallowing Interaction of Ventilator Dependent Neuromuscular Patients: A Prospective Crossover Study. |
| المؤلفون: |
Garguilo, Marine, Lejaille, Michèle, Vaugier, Isabelle, Orlikowski, David, Terzi, Nicolas, Lofaso, Frédéric, Prigent, Hélène |
| المصدر: |
PLoS ONE; 3/3/2016, Vol. 11 Issue 3, p1-11, 11p |
| مصطلحات موضوعية: |
NEUROMUSCULAR diseases, ARTIFICIAL respiration, DEGLUTITION, MECHANICAL ventilators, LONGITUDINAL method, PATIENTS |
| مستخلص: |
Background: Respiratory involvement in neuromuscular disorders may contribute to impaired breathing-swallowing interactions, swallowing disorders and malnutrition. We investigated whether the use of non-invasive ventilation (NIV) controlled by the patient could improve swallowing performances in a population of neuromuscular patients requiring daytime NIV. Methods: Ten neuromuscular patients with severe respiratory failure requiring extensive NIV use were studied while swallowing without and with NIV (while ventilated with a modified ventilator allowing the patient to withhold ventilation as desired). Breathing-swallowing interactions were investigated by chin electromyography, cervical piezoelectric sensor, nasal flow recording and inductive plethysmography. Two water-bolus sizes (5 and 10ml) and a textured yogurt bolus were tested in a random order. Results: NIV use significantly improved swallowing fragmentation (defined as the number of respiratory interruption of the swallowing of a single bolus) (p = 0.003) and breathing-swallowing synchronization (with a significant increase of swallows followed by an expiration) (p <0.0001). Patient exhibited piecemeal swallowing which was not influenced by NIV use (p = 0.07). NIV use also significantly reduced dyspnea during swallowing (p = 0.04) while preserving swallowing comfort, regardless of bolus type. Conclusion: The use of patient controlled NIV improves swallowing parameters in patients with severe neuromuscular respiratory failure requiring daytime NIV, without impairing swallowing comfort. Trial Registration: ClinicalTrials.gov [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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